Abstract: It is disclosed a device for multipole phase division multiplexing and demultiplexing and a spatial division telecommunications system comprising the multiplexing and demultiplexing devices. The multipole phase demultiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a circular-sector transformation of a plurality of multipole phase electromagnetic beams. The multipole phase multiplexing device comprises a cascade of a beam transformer and a phase corrector, wherein the beam transformer performs a combination of |m | circular-sector transformations of a plurality of tilted electromagnetic beams.

Abstract: Provided is an atomic vapor cell, for atomic or molecular spectroscopy, optical pumping, and/or spin-based atomic sensing, that includes a host substrate and defined there within a buried or non-buried chamber laser written in the host substrate without the need of a mask or photoresist, with either planar or three-dimensional geometry, and intended to contain an atomic vapor. Also provided are an integrated atomic/photonic device and an apparatus, in both cases including the presently disclosed atomic vapor cell, and a method for fabricating the presently disclosed atomic vapor cell.

Abstract: A method for detecting a viral agent including the steps of placing a first sample that includes an isotonic solution in a waveguide which is axially delimited by a pair of containment elements that are substantially transparent to microwaves and define respective interfaces of the sample; transmitting a signal with frequency variable in a predetermined microwave band to the first sample; acquiring at least one dielectric parameter of the first sample as the frequency varies by means of transmission and reflection measurements; repeating the previous steps for a second sample; and performing a differential spectroscopic analysis on the parameters for assessing the presence of a viral agent in at least one of the samples.

Abstract: The present invention relates to a computer-implemented method and corresponding apparatus for the accurate identification of subcellular structures from tomographic reconstructions. This invention allows to extract the 3D subcellular specificity directly from the tomographic phase-contrast data obtained from a typical flow cytometry configuration or any other experimental tomographic systems able to provide 3D quantitative phase-contrast tomograms. In particular, subcellular structures can be identified by using a novel computational segmentation method based on statistical inference from any 3D phase-contrast tomographic data.

Abstract: Disclosed is an apparatus and a method. Spin-splitting is induced at a superconductor and spin-polarization facilitated for tunneling across a tunnel barrier so that electric current across the tunnel barrier between a conductor and the superconductor flows primarily in one direction.

Abstract: A microfluidic patch for separating specific species in biological fluids, comprising a flow layer comprising: a first porous portion to receive and carry a starting biological fluid containing related species; a multilayer membrane downstream the first porous portion and comprising a plurality of graphene-based sheets spaced among each other to define a plurality of parallel channels transversally interconnected and chemically functionalized to provide from the starting biological fluid an outgoing flow of specific species to be detected; and a second porous portion placed downstream the multilayer membrane to receive and carry the outgoing flow to be detected; the patch comprises a first upstream electrode and a first downstream electrode placed respectively upstream and downstream the multilayer membrane to foster the flow through the multilayer membrane from the first to the second porous portion.

Abstract: Described is a directional gamma detector including a detection probe and a handgrip, wherein the detection probe includes: a supporting rod and a detection head coupled or integrated with a first end of the supporting rod. The detection head includes a plurality of detection elements distinct from each other for simultaneously detecting gamma rays directed in different directions and including at least one scintillation crystal and a corresponding first electronic conversion circuitry. Each detection element is associated with a respective collimator. The handgrip is equipped internally with a second electronic circuitry for converting the signals. The detection probe, and in particular a second end of the supporting rod, is reversibly connectable to the handgrip by a mechanical connector equipped with electrical contacts for transferring the signals from the first electronic conversion circuitry to the second electronic conversion circuitry.

Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

Abstract: The present invention relates to a di Cinnamomum zeylanicum EO, or to an association comprising said EO and one or more antitumour drug, for use in the treatment or in adjuvating the treatment of melanoma. The invention relates also to a pharmaceutical composition comprising said EO or said association and at least a pharmaceutically acceptable carrier for use in the treatment or in adjuvating the treatment of melanoma.

Abstract: An optical device for controlling light from an external light source including: at least a first and a second waveguide for guiding a light beam emitted from the external light source; and at least a first beam shaping structure with a first light emitting area for emitting a light beam and a second beam shaping structure with a second light emitting area for emitting a light beam, wherein the first waveguide guides the light beam emitted from the external light source to the first beam shaping structure and the second waveguide guides the light beam emitted from the external light source to the second beam shaping structure; wherein the first and the second beam shaping structure-are each configured such that the uniformity of the radiant density profile of a light beam emitted from the respective light emitting area of the respective beam shaping structure is higher than that of the light beam guided to the respective beam shaping structure by the respective waveguide.

Abstract: The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.

Abstract: Method of doping a semiconductor sample in a uniform and carbon-free way, wherein said sample has a surface, comprising the following steps: A. removing oxides from at least part of the said surface; B. dip coating said at least part of the surface of the sample in a dopant based carbon-free solution of at least one dopant based carbon free substance diluted in water, wherein said at least one dopant based carbon free substance has a molecule comprising at least one dopant atom, wherein the dip coating is achieved by heating said dopant based carbon-free solution at a dip coating temperature from 65% to 100% of the boiling temperature of said dopant based carbon-free solution, thereby a self-assembled mono-layer including dopant atoms is formed; C. annealing said sample, wherein the annealing is configured to cause said dopant atoms included in said self-assembled mono-layer to be diffused into the sample.

Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Abstract: The present invention concerns an extract from pomegranate (Punica granatum L), specifically obtained from one or more immature pomegranate fruits. This extract is obtained through an extraction process including steps a)-d) as described in the text and it may contain gallotannins, ellagitannins, ellagic acid derivatives and granatins. Pharmaceutical and nutraceutical compositions and food supplements comprising this extract fall within the scope of the present invention as well as their use in various fields, more specifically for the treatment of tumors.

Abstract: The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.

Abstract: A monitoring device of biological cells including: a fluidic channel in which a fluid including biological cells is made to flow, including a first and second glass walls placed in parallel and a reflective surface adjoined to the second wall; and a piezoelectric transducer, the piezoelectric transducer emitting acoustic waves creating a force acting on the biological cells, making them flow substantially along a single motion plane. The external interface between the first wall and the exterior of the fluidic channel and the reflective surface are configured to function as a Fabry-Perot interferometer, such that the motion planes sensibly perpendicular to the optical axis of the Fabry-Perot interferometer. The finesse of the interferometer is lower than 10.

Abstract: The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.

Abstract: The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

Abstract: This specification discusses a device which modulates, simultaneously or independently, the amplitude, polarization and phase of the electromagnetic radiation. This device has multiple metasurfaces, a spacer region between the metasurfaces, and an actuator for applying a force to at least one of the metasurfaces. The application of the force changes distance between at least two of the metasurfaces creating the of the electromagnetic radiation.

Abstract: Provided are methods of transducing hair cells of the inner ear in a subject comprising administering to the subject an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a capsid comprising the amino acid sequence of SEQ ID NO: 1, wherein the AAV vector further comprises a heterologous nucleic acid sequence. Additionally, methods of treating, preventing, or inhibiting a cochlear disorder or balance disorder in a subject comprising administering the AAV vector to the subject are provided.