Patents Assigned to Consiglio Nazionale Delle Ricerche
  • Publication number: 20200206138
    Abstract: A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.
    Type: Application
    Filed: June 13, 2018
    Publication date: July 2, 2020
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Annalisa ALUIGI, Greta VARCHI, Giovanna SOTGIU, Andrea GUERRINI, Marco BALLESTRI
  • Publication number: 20200197342
    Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A.
    Type: Application
    Filed: August 20, 2018
    Publication date: June 25, 2020
    Applicants: ALIOPHARM S.R.L., Consiglio Nazionale delle Ricerche
    Inventors: Gian Luigi Russo, Fabrizio Tarricone, Idolo Tedesco
  • Patent number: 10682633
    Abstract: Some embodiments are directed to a new methodology aimed at preparing highly N-doped mesoporous carbon macroscopic composites, and their use as highly efficient heterogeneous metal-free catalysts in a number of industrially relevant catalytic transformations.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: June 16, 2020
    Assignees: UNIVERSITÉDE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Cuong Pham-Huu, Giuliano Giambastiani, Yuefeng Liu, Housseinou Ba, Lam Nguyen-Dinh, Jean-Mario Nhut, Cuong Duong-Viet
  • Patent number: 10571398
    Abstract: The present invention concerns a device constituted by a planar optical antenna which allows to beam and collect light emitted from various light sources, including light-emitting devices (LEDs), fluorescent markers and single-photon sources. By considering the light source as a light receiver and using reciprocity, the device can also be used to improve the absorption of light by various receivers, including molecules. This device is in particular suitable for in-vitro diagnostics (IVD).
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: February 25, 2020
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Mario Agio, Costanza Toninelli, Simona Checcucci, Fabrizio Sgrignuoli, Sahrish Rizvi, Pietro Ernesto Lombardi
  • Patent number: 10574966
    Abstract: The present invention relates to a method for modifying at least one video frame of a digital video stream to be displayed on a display area. Each correction scheme has one or more specific digital filters based on visual defects perceived by a person with respect to a video frame portion, is configured when predetermined conditions are met and reconfigured whenever the origin position of an eye reference system associated with a respective eye is different from the position of the same origin in said predetermined conditions and/or the orientation of said eye reference system is different from the orientation of the same eye reference system in said predetermined conditions.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: February 25, 2020
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Carmelo Lodato, Patrizia Ribino
  • Patent number: 10525161
    Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: January 7, 2020
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, JOINTHERAPEUTICS S.R.L.
    Inventors: Luigi Ambrosio, Maria Grazia Raucci, Angela Longo, Gianfranco Carotenuto, Daniela Giugliano
  • Patent number: 10525432
    Abstract: There is described a versatile and environment-friendly one-pot process for the preparation of nanoparticles of noble metals in hydrogel, obtainable at room temperature using quaternized hydroxyethylcellulose.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 7, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Anna Luisa Costa, Magda Blosi
  • Patent number: 10520425
    Abstract: An integrated optofluidic device to illuminate, along an irradiation direction, a fluidic sample containing an object to be analysed, the device comprising: a substrate comprising an entry surface and being made of a material transparent to a light beam incident through the entry surface along the irradiation direction; a microfluidic channel formed in the substrate and having a channel portion intercepting the irradiation direction and extending along a longitudinal axis transverse to the irradiation direction, the microfluidic channel comprising a first flow inlet port for loading a fluidic sample therein, and an elongated lens cavity for an optofluidic cylindrical lens, the cavity being formed in the substrate and being arranged along the beam irradiation direction between the entry surface and the microfluidic channel, wherein the lens cavity is in fluid communication with a lens inlet port for loading a lens fluid.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: December 31, 2019
    Assignees: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE-CNR
    Inventors: Andrea Bassi, Petra Paiè, Roberto Osellame, Francesca Bragheri
  • Publication number: 20190343965
    Abstract: The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.
    Type: Application
    Filed: January 29, 2018
    Publication date: November 14, 2019
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Piergiuseppe DE BERARDINIS, Rossella SARTORIUS
  • Publication number: 20190339504
    Abstract: A system and a method for measuring the focus state of an optical instrument are described. The system and the method provide for forming an image of the exit pupil of the objective of the optical instrument. Where the image of the exit pupil is formed, one or more optical elements are placed, deviating at least part of the rays coming from the exit pupil, so that rays coming from different non-overlapping portions of the pupil follow separate optical paths. The rays coming from the two portions of the pupil are then focused, in order to obtain two bidimensional images. A computer determines the mutual distance between these two bidimensional images as a mutual rigid lateral displacement between the two and, based on this distance, determines the corresponding defocus of the optical instrument.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 7, 2019
    Applicants: LABORATORIO EUROPEO Dl SPETTROSCOPIE NON LINEARI (LENS), CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITA' DEGLI STUDI Dl FIRENZE
    Inventors: Ludovico SILVESTRI, Marie Caroline MULLENBROICH, Leonardo SACCONI, Francesco Saverio PAVONE
  • Publication number: 20190310085
    Abstract: A system for monitoring a building structure is described. The system comprises a laser source which emits an infrared radiation and an interferometric arrangement which divides the radiation into an object beam and a reference beam. The object beam irradiates the building structure and is scattered by it, while the reference beam interferes with the scattered object beam so as to create a hologram of the building. The system also comprises a sensor which detects a sequence of holograms and a processing unit which reconstructs the evolution in time of deformations or displacements of the building by numerically processing the sequence of holograms. The system—being based on digital holography—offers various advantages compared to known monitoring techniques, for example techniques which make use of seismometers (possibility of remote monitoring, substantial space-time continuity of the monitoring, capacity for detecting a wider range of deformations and displacements).
    Type: Application
    Filed: May 1, 2019
    Publication date: October 10, 2019
    Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITA DEGLI STUDI DI FIRENZE
    Inventors: Massimiliano LOCATELLI, Pasquale POGGI, Eugenio PUGLIESE, Giorgio LACANNA
  • Patent number: 10429519
    Abstract: A system (10) for the remote detection of substances, comprising a vehicle (20) that is mobile in space and remote-piloted using a control device (40) with a haptic interface suitable to return a force feedback to a user of the control device (40), wherein the vehicle (20) is equipped with a position sensor (22) and a sensor (21) for detecting a physical quantity whose intensity depends on the distance of at least one substance present in a detection point located in a vicinity of the position of the vehicle (20).
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 1, 2019
    Assignees: UNIVERSITA DEGLI STUDI DI PARMA, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Jacopo Aleotti, Stefano Caselli, Giorgio Micconi, Giacomo Benassi, Nicola Zambelli, Andrea Zappettini, Davide Calestani
  • Patent number: 10364299
    Abstract: The present invention relates to a derivative of carnosine (?-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 30, 2019
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, FIDIA FARMACEUTICI S.P.A.
    Inventors: Sebastiano Sciuto, Valentina Greco, Enrico Rizzarelli, Francesco Bellia, Valeria Lanza, Susanna Vaccaro, Luciano Messina
  • Publication number: 20190224288
    Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, in the therapeutic treatment of paralysis caused by spinal cord injury.
    Type: Application
    Filed: January 21, 2019
    Publication date: July 25, 2019
    Applicant: Consiglio Nazionale Delle Ricerche
    Inventors: Sara Marinelli, Flaminia Pavone, Siro Luvisetto, Valentina Vacca
  • Patent number: 10350063
    Abstract: A process for the manufacture of a heart valve of polymer material which provides for the deposition of a polymer solution comprising a copolymer which is preferably a copolymer of poly(carbonato-urethane) fluoridate (F-PCU) and intracatenary polydimethylsiloxane (PDMS), a PDMS with a functional group outside the chain and a solvent onto a mould using a spray technique associated with phase inversion.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 16, 2019
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, HUMANIT AS MIRASOLE S.P.A.
    Inventors: Giorgio Soldani, Mattia Glauber
  • Patent number: 10301367
    Abstract: The present invention features modified human transcription factors capable of increasing utrophin expression, recombinant adeno-associated vectors for delivery of the modified human transcription factors, and methods of treating muscle diseases, including Duchenne's muscular dystrophy.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: May 28, 2019
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Claudio Passananti, Nicoletta Corbi, Maria Grazia Di Certo, Elisabetta Mattei, Cinzia Pisani, Georgios Strimpakos, Siro Luvisetto
  • Patent number: 10286085
    Abstract: The present invention features recombinant adeno-associated vectors for delivery of genes to both skeletal and cardiac muscle and methods for treatment of muscle defects, including Duchenne's muscular dystrophy.
    Type: Grant
    Filed: July 26, 2014
    Date of Patent: May 14, 2019
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Claudio Passananti, Nicoletta Corbi, Maria Grazia Di Certo, Elisabetta Mattei, Cinzia Pisani, Georgios Strimpakos
  • Patent number: 10242884
    Abstract: A field-effect transistor and method for fabricating such a field-effect transistor that utilizes an air-sensitive two-dimensional material (e.g., silicene). A film of air-sensitive two-dimensional material is deposited on a crystalized metallic (e.g., Ag) thin film on a substrate (e.g., mica substrate). A capping layer of insulating material (e.g., aluminum oxide) is deposited on the air-sensitive two-dimensional material. The substrate is detached from the metallic thin film/air-sensitive two-dimensional material/insulating material stack structure. The metallic thin film/air-sensitive two-dimensional material/insulating material stack structure is then flipped. The flipped metallic thin film/air-sensitive two-dimensional material/insulating material stack structure is attached to a device substrate followed by having the metallic thin film etched to form contact electrodes. In this manner, the pristine properties of air-sensitive two-dimensional materials are preserved from degradation when exposed to air.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: March 26, 2019
    Assignees: Board of Regents, The University of Texas System, Consiglio Nazionale delle Ricerche
    Inventors: Deji Akinwande, Li Tao, Carlo Grazianetti, Alessandro Molle
  • Publication number: 20190062223
    Abstract: The present invention relates to a process for the production of fiber-reinforced composite materials with an ultra-refractory, high tenacity, high ablation resistant matrix with self-healing properties, prepared from highly sinterable slurries. The composite material is produced using techniques of infiltration and drying at ambient pressure or under vacuum, and consolidated by sintering with or without the application of gas or mechanical pressure.
    Type: Application
    Filed: January 26, 2017
    Publication date: February 28, 2019
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Diletta Sciti, Luca Zoli, Valentina Medri
  • Patent number: 10101208
    Abstract: The present invention relates to a ring-down spectrometry apparatus in absorption saturation condition, for measuring the concentration of a gas through a measurement of the spectrum of a molecular transition of said gas. The apparatus includes a laser source, an adjuster for varying the wavelength of said radiation emitted by said laser, and a resonant cavity. A photodetector is adapted to detect an electromagnetic radiation beam and is adapted to generate a decay signal. An electronic circuit receives the signal from the photodetector and is adapted to convert it to a processor. A processor is adapted to receive said decay signal from the photodetector and perform interpolation to obtain a concentration of said gas.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: October 16, 2018
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Giovanni Giusfredi, Iacopo Galli, Pablo Cancio Pastor, Davide Mazzotti, Paolo De Natale