Patents Assigned to Consiglio Nazionale Delle Ricerche
  • Patent number: 11084854
    Abstract: A protease-resistant neurotrophic peptide is provided. A pharmaceutical composition including the protease-resistant neurotrophic peptide in a pharmaceutically acceptable carrier, in combination with optional adjuvants, stabilizers and/or preservatives, is also provided.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 10, 2021
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Luigi Manni, Marzia Soligo
  • Publication number: 20210230255
    Abstract: The present invention refers to an antibody or an antigen binding fragment thereof against a tau-derived neurotoxic peptide for use in the treatment and/or prevention of Alzheimer's disease (AD) or a non-AD tauopathy, as well as pharmaceutical compositions comprising the same.
    Type: Application
    Filed: April 29, 2019
    Publication date: July 29, 2021
    Applicants: FONDAZIONE EBRI RITA LEVI-MONTALCINI, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Giuseppina AMADORO, Pietro CALISSANO, Veronica CORSETTI
  • Publication number: 20210181022
    Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.
    Type: Application
    Filed: July 25, 2019
    Publication date: June 17, 2021
    Applicants: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Cristian Angelo MANZONI, Giulio CERULLO, Dario POLLI, Antonio PERRI, Fabrizio PREDA, Gianluca VALENTINI, Andrea BASSI
  • Patent number: 11027045
    Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 8, 2021
    Assignees: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE, FONDAZIONE CARIPLO
    Inventors: Manuela Teresa Raimondi, Giulio Cerullo, Roberto Osellame, Andrea Remuzzi
  • Publication number: 20210147395
    Abstract: The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 20, 2021
    Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, MOLIPHARMA S.R.L.
    Inventors: Maria Cristina DE ROSA, Davide PIROLLI, Giovanni SCAMBIA, Daniela GALLO, Marco PETRILLO, Marta DE DONATO, Benedetta RIGHINO
  • Patent number: 11005023
    Abstract: A superconducting logic element includes a superconducting tunnel junction including first and second superconductors. First and second insulating ferromagnets in contact with the first and second superconductors, respectively, generate by magnetic proximity effect a predetermined density of spin-split states in the first and second superconductors, respectively. A writing element applies a writing current to at least a superconductor and is in contact with one of the first or second insulating ferromagnets, so that the first and second insulating ferromagnets commute, by the magnetic field generated by the applied writing current, between a state with parallel magnetization to a state with antiparallel magnetization with respect to each other.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: May 11, 2021
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSIDAD DEL PAÍS VASCO (UPV)
    Inventors: Francesco Giazotto, Elia Strambini, Giorgio De Simoni, F. Sebastian Bergeret Sbarbaro
  • Patent number: 10980745
    Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: April 20, 2021
    Assignees: SIFI S.p.A., Consiglio Nazionale delle Ricerche
    Inventors: Elena Solfato, Ilenia Abbate, Cristina Maria Concetta Zappulla, Manuela Santonocito, Santa Viola, Sandro De Falco, Francesco Giuliano
  • Publication number: 20210103163
    Abstract: This specification discusses a device which modulates, simultaneously or independently, the amplitude, polarization and phase of the electromagnetic radiation. This device has multiple metasurfaces, a spacer region between the metasurfaces, and an actuator for applying a force to at lease one of the metasurfaces. The application of the force changes distance between at least two of the metasurfaces creating the tunability of the electromagnetic radiation.
    Type: Application
    Filed: September 30, 2020
    Publication date: April 8, 2021
    Applicant: Consiglio Nazionale delle Ricerche
    Inventors: Simone ZANOTTO, Alessandro PITANTI
  • Publication number: 20210102191
    Abstract: The present invention relates to a method for the isolation of intact extracellular vesicles from biological tissues and fluids. Under a further aspect, the present invention relates intact extracellular vesicles, obtainable from the method herein described, and their use as a diagnostic and therapeutic tool.
    Type: Application
    Filed: October 7, 2020
    Publication date: April 8, 2021
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventor: Marcella Chiari
  • Patent number: 10933384
    Abstract: The object of the present invention is a new cryopolymerization process that provides crosslinked polymeric materials in the form of a macroporous gel (cryogel) capable of sequestering (neutralize) the anticoagulant heparin, its low molecular weight derivatives (LMWH and ULMWH) and heparinoids, from aqueous solutions, physiological solutions and biological fluids, such as whole blood, serum and plasma. A further object of the invention are also crosslinked polymeric materials in the form of a macroporous gel (cryogel) obtained by the cryopolymerization process of the invention that, thanks to said specific process, result to be comprised of varying proportions of HEMA and HEMA-R monomers. The molar ratio between the components (HEMA/HEMA-R) may vary between 99.9% HEMA:0.1% HEMA-R and 0.1% HEMA:99.9% HEMA-R.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: March 2, 2021
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Francesca Cunsolo, Tommaso Mecca, Rita La Spina, Fabiola Spitaleri
  • Patent number: 10879059
    Abstract: An elongated microwave powered lamp (1) having one or more bulbs with any length or shape or disposition according to a linear series, straight or curved, includes: at least one transparent elongated bulb (2) containing, in an inner space thereof, a material apt to be excited by microwave irradiation thereby emitting an electromagnetic radiation; a coaxial microwave antenna placed outside the bulb (2) and respectively connected to a microwave source (81) via corresponding antenna lead (91), said bulb (2) and said at least one microwave coaxial antenna being displaced in a close relationship to each other to allow the microwave excitation of said material, wherein the outer tubular conductor of the coaxial antenna (5) has spaced holes (6) formed therethrough and facing the bulb (2), at which microwaves are released toward the bulb.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 29, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Carlo Ferrari, Iginio Longo
  • Publication number: 20200371025
    Abstract: A method to measure the refractive index of a sample, includes: providing a plasmonic sensor including a sensing surface in contact with the sample; providing an optical resonator, the plasmonic sensor being integrated therein as a reflecting surface; providing a first input field of electromagnetic radiation as a primary carrier; providing a second input field of electromagnetic radiation as a secondary carrier having a second frequency different from the first and defined as: second frequency=first frequency+?v and having a TE and/or a TM polarized component; impinging simultaneously with the first and second input field the plasmonic sensor; tuning the frequency of the first field and/or the value of ?v; detecting a resonator output power corresponding to the first and second intra-cavity fields resonating; determining a difference between the first and the second resonating frequencies; and calculating the refractive index of the sample from the difference.
    Type: Application
    Filed: November 16, 2018
    Publication date: November 26, 2020
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE - CNR
    Inventors: Antonio GIORGINI, Saverio AVINO, Pietro MALARA, Gianluca GAGLIARDI, Paolo DE NATALE
  • Patent number: 10813856
    Abstract: The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: October 27, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Anna Tampieri, Monica Sandri, Simone Sprio
  • Patent number: 10780149
    Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, in the therapeutic treatment of paralysis caused by spinal cord injury.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: September 22, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Sara Marinelli, Flaminia Pavone, Siro Luvisetto, Valentina Vacca
  • Patent number: 10741747
    Abstract: The present invention relates to a zinc oxide-based piezoelectric device, utilizable both as a sensor and as an actuator. More in particular, the present invention relates to a piezoelectric device (1, 101) comprising at least two carbon fibre crossed yarns (2a, 2b; 102a, 102b), at the intersection of which a zinc oxide layer (3, 103) in nanorod form is arranged, wherein an end (4a, 4b) of each of said yarns (2a, 2b; 102a, 102b) is connected to an operative unit (5).
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: August 11, 2020
    Assignees: Bercella S.r.l., CNR Consiglio Nazionale delle Ricerche
    Inventors: Davide Calestani, Nicola Coppede, Maurizio Culiolo, Davide Delmonte, Marco Lani, Andrea Zappetini, Laura Marchini, Rocco Bercella
  • Patent number: 10722574
    Abstract: The present invention relates to beta-glycolipid derivatives, their preparation and use as adjuvants in vaccines, as being suitable for being co-administered with antigens for vaccine prophylaxis and therapy. In certain embodiments, the beta-glycolipid derivatives of the invention also in their salified or complex form, are suitable for being co-administered with antigens for both therapeutic and prophylactic purposes or for vaccine prophylaxis and therapy.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: July 28, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Angelo Fontana, Emiliano Manzo, Adele Cutignano, Raffaele De Palma
  • Publication number: 20200227617
    Abstract: A superconducting logic element includes a superconducting tunnel junction including first and second superconductors. First and second insulating ferromagnets in contact with the first and second superconductors, respectively, generate by magnetic proximity effect a predetermined density of spin-split states in the first and second superconductors, respectively. A writing element applies a writing current to at least a superconductor and is in contact with one of the first or second insulating ferromagnets, so that the first and second insulating ferromagnets commute, by the magnetic field generated by the applied writing current, between a state with parallel magnetization to a state with antiparallel magnetization with respect to each other.
    Type: Application
    Filed: August 23, 2018
    Publication date: July 16, 2020
    Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), UNIVERSIDAD DEL PAÍS VASCO (UPV)
    Inventors: Francesco GIAZOTTO, Elia STRAMBINI, Giorgio DE SIMONI, F. Sebastian BERGERET SBARBARO
  • Publication number: 20200206138
    Abstract: A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.
    Type: Application
    Filed: June 13, 2018
    Publication date: July 2, 2020
    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Annalisa ALUIGI, Greta VARCHI, Giovanna SOTGIU, Andrea GUERRINI, Marco BALLESTRI
  • Publication number: 20200197342
    Abstract: Method for the production of a polyphenolic composition from barley malt, including the fundamental steps of: grinding of the malt grains and splitting into two portions, 20% and 80%; mixing each of the two portions with water to obtain an A mixture and a B mixture, the A mixture being prepared with the 20% portion to obtain a mixture of the malt in water at a final concentration between 9.5% and 20%, the B mixture being prepared with the 80% portion to obtain a mixture of the malt in water at a final concentration between 33% and 60%; thermal cycle; separation of the liquid component from the solid component; boiling of the liquid component and the addition of hops; rapid cooling of the wort; storage; in which said thermal cycle consists of a first phase and a second phase, in which the first phase applies to the 20% portion (Mixture A) and the second phase during which Mixture B is added to Mixture A.
    Type: Application
    Filed: August 20, 2018
    Publication date: June 25, 2020
    Applicants: ALIOPHARM S.R.L., Consiglio Nazionale delle Ricerche
    Inventors: Gian Luigi Russo, Fabrizio Tarricone, Idolo Tedesco
  • Patent number: 10682633
    Abstract: Some embodiments are directed to a new methodology aimed at preparing highly N-doped mesoporous carbon macroscopic composites, and their use as highly efficient heterogeneous metal-free catalysts in a number of industrially relevant catalytic transformations.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: June 16, 2020
    Assignees: UNIVERSITÉDE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Cuong Pham-Huu, Giuliano Giambastiani, Yuefeng Liu, Housseinou Ba, Lam Nguyen-Dinh, Jean-Mario Nhut, Cuong Duong-Viet