Abstract: The present invention relates to a process for preparing a composite, ultra-refractory, fibre-reinforced ceramic material obtained through the infiltration of carbon and/or silicon carbide fibres with a ceramic suspension comprising yttrium, lanthanum and/or scandium compounds, and the subsequent densification of the composite. The fibre-reinforced UHTC compounds obtained by the process can be used for making items intended for use in extreme temperature and pressure conditions.
Type:
Application
Filed:
November 20, 2019
Publication date:
January 6, 2022
Applicant:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Luca Zoli, Diletta Sciti, Laura Silvestroni, Antonio Vinci
Abstract: A multifunctional solid-state photovoltachromic device (1) comprising at least one n-type layer (8) and at least one p-type layer (11) arranged to create a PN or PIN junction, said n-type layer (8) and p-type layer (11) comprising materials arranged to act as mixed conductors, thus allowing both charge transport and ion conduction.
Type:
Grant
Filed:
June 8, 2018
Date of Patent:
November 30, 2021
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Alessandro Cannavale, Pierluigi Cossari, Vincenzo Maiorano, Giuseppe Gigli
Abstract: The present invention relates to a process for the production of fiber-reinforced composite materials with an ultra-refractory, high tenacity, high ablation resistant matrix with self-healing properties, prepared from highly sinterable slurries. The composite material is produced using techniques of infiltration and drying at ambient pressure or under vacuum, and consolidated by sintering with or without the application of gas or mechanical pressure.
Abstract: A device is disclosed for detecting time-resolved optical data, the device comprising a sensor comprising a number of detection elements configured to detect a light signal in a single photon regime, a timing circuit connected to said number of detection elements though a common line, and a control module connected to the sensor, the control module being configured to selectively enable the detection elements of the sensor according to a set of enabling patterns. The timing circuit is configured to measure a time of arrival of an output signal from the detection elements on the common line, the output signal being indicative of the detection of a photon of the light signal by any of the enabled detection elements.
Type:
Application
Filed:
July 22, 2019
Publication date:
October 14, 2021
Applicants:
POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITY COLLEGE LONDON
Inventors:
Cosimo D'ANDREA, Gianluca VALENTINI, Andrea FARINA, Simon ARRIDGE
Abstract: The present invention relates to a membrane chromatography process for selectively separating and purifying phycobiliproteins starting from aqueous biomasses of cyanobacteria and algae that, in a short time and at reduced cost, allows to obtain phycobiliproteins with a high degree of purity for use in pharmaceutical, cosmetic, or food compositions or as reagents for research.
Type:
Application
Filed:
June 4, 2019
Publication date:
September 30, 2021
Applicant:
Consiglio Nazionale delle Ricerche
Inventors:
Rosaria LAUCERI, Giuseppe TORZILLO, Graziella CHINI ZITTELLI
Abstract: A protease-resistant neurotrophic peptide is provided. A pharmaceutical composition including the protease-resistant neurotrophic peptide in a pharmaceutically acceptable carrier, in combination with optional adjuvants, stabilizers and/or preservatives, is also provided.
Abstract: The present invention refers to an antibody or an antigen binding fragment thereof against a tau-derived neurotoxic peptide for use in the treatment and/or prevention of Alzheimer's disease (AD) or a non-AD tauopathy, as well as pharmaceutical compositions comprising the same.
Type:
Application
Filed:
April 29, 2019
Publication date:
July 29, 2021
Applicants:
FONDAZIONE EBRI RITA LEVI-MONTALCINI, CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Giuseppina AMADORO, Pietro CALISSANO, Veronica CORSETTI
Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.
Type:
Application
Filed:
July 25, 2019
Publication date:
June 17, 2021
Applicants:
POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Cristian Angelo MANZONI, Giulio CERULLO, Dario POLLI, Antonio PERRI, Fabrizio PREDA, Gianluca VALENTINI, Andrea BASSI
Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
Type:
Grant
Filed:
August 31, 2016
Date of Patent:
June 8, 2021
Assignees:
POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE, FONDAZIONE CARIPLO
Inventors:
Manuela Teresa Raimondi, Giulio Cerullo, Roberto Osellame, Andrea Remuzzi
Abstract: The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.
Type:
Application
Filed:
April 2, 2019
Publication date:
May 20, 2021
Applicants:
CONSIGLIO NAZIONALE DELLE RICERCHE, MOLIPHARMA S.R.L.
Inventors:
Maria Cristina DE ROSA, Davide PIROLLI, Giovanni SCAMBIA, Daniela GALLO, Marco PETRILLO, Marta DE DONATO, Benedetta RIGHINO
Abstract: A superconducting logic element includes a superconducting tunnel junction including first and second superconductors. First and second insulating ferromagnets in contact with the first and second superconductors, respectively, generate by magnetic proximity effect a predetermined density of spin-split states in the first and second superconductors, respectively. A writing element applies a writing current to at least a superconductor and is in contact with one of the first or second insulating ferromagnets, so that the first and second insulating ferromagnets commute, by the magnetic field generated by the applied writing current, between a state with parallel magnetization to a state with antiparallel magnetization with respect to each other.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
May 11, 2021
Assignees:
CONSIGLIO NAZIONALE DELLE RICERCHE, UNIVERSIDAD DEL PAÍS VASCO (UPV)
Inventors:
Francesco Giazotto, Elia Strambini, Giorgio De Simoni, F. Sebastian Bergeret Sbarbaro
Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.
Type:
Grant
Filed:
October 1, 2019
Date of Patent:
April 20, 2021
Assignees:
SIFI S.p.A., Consiglio Nazionale delle Ricerche
Inventors:
Elena Solfato, Ilenia Abbate, Cristina Maria Concetta Zappulla, Manuela Santonocito, Santa Viola, Sandro De Falco, Francesco Giuliano
Abstract: This specification discusses a device which modulates, simultaneously or independently, the amplitude, polarization and phase of the electromagnetic radiation. This device has multiple metasurfaces, a spacer region between the metasurfaces, and an actuator for applying a force to at lease one of the metasurfaces. The application of the force changes distance between at least two of the metasurfaces creating the tunability of the electromagnetic radiation.
Abstract: The present invention relates to a method for the isolation of intact extracellular vesicles from biological tissues and fluids. Under a further aspect, the present invention relates intact extracellular vesicles, obtainable from the method herein described, and their use as a diagnostic and therapeutic tool.
Abstract: The object of the present invention is a new cryopolymerization process that provides crosslinked polymeric materials in the form of a macroporous gel (cryogel) capable of sequestering (neutralize) the anticoagulant heparin, its low molecular weight derivatives (LMWH and ULMWH) and heparinoids, from aqueous solutions, physiological solutions and biological fluids, such as whole blood, serum and plasma. A further object of the invention are also crosslinked polymeric materials in the form of a macroporous gel (cryogel) obtained by the cryopolymerization process of the invention that, thanks to said specific process, result to be comprised of varying proportions of HEMA and HEMA-R monomers. The molar ratio between the components (HEMA/HEMA-R) may vary between 99.9% HEMA:0.1% HEMA-R and 0.1% HEMA:99.9% HEMA-R.
Type:
Grant
Filed:
February 9, 2017
Date of Patent:
March 2, 2021
Assignee:
Consiglio Nazionale Delle Ricerche
Inventors:
Francesca Cunsolo, Tommaso Mecca, Rita La Spina, Fabiola Spitaleri
Abstract: An elongated microwave powered lamp (1) having one or more bulbs with any length or shape or disposition according to a linear series, straight or curved, includes: at least one transparent elongated bulb (2) containing, in an inner space thereof, a material apt to be excited by microwave irradiation thereby emitting an electromagnetic radiation; a coaxial microwave antenna placed outside the bulb (2) and respectively connected to a microwave source (81) via corresponding antenna lead (91), said bulb (2) and said at least one microwave coaxial antenna being displaced in a close relationship to each other to allow the microwave excitation of said material, wherein the outer tubular conductor of the coaxial antenna (5) has spaced holes (6) formed therethrough and facing the bulb (2), at which microwaves are released toward the bulb.
Abstract: A method to measure the refractive index of a sample, includes: providing a plasmonic sensor including a sensing surface in contact with the sample; providing an optical resonator, the plasmonic sensor being integrated therein as a reflecting surface; providing a first input field of electromagnetic radiation as a primary carrier; providing a second input field of electromagnetic radiation as a secondary carrier having a second frequency different from the first and defined as: second frequency=first frequency+?v and having a TE and/or a TM polarized component; impinging simultaneously with the first and second input field the plasmonic sensor; tuning the frequency of the first field and/or the value of ?v; detecting a resonator output power corresponding to the first and second intra-cavity fields resonating; determining a difference between the first and the second resonating frequencies; and calculating the refractive index of the sample from the difference.
Type:
Application
Filed:
November 16, 2018
Publication date:
November 26, 2020
Applicant:
CONSIGLIO NAZIONALE DELLE RICERCHE - CNR
Inventors:
Antonio GIORGINI, Saverio AVINO, Pietro MALARA, Gianluca GAGLIARDI, Paolo DE NATALE
Abstract: The present invention relates to a composition for the protection against solar radiation, consisting of an organic matrix, preferably a gelatin, and hydroxyapatite nanoparticles modified by the substitution of part of the phosphorus with titanium, and part of the calcium with iron.
Type:
Grant
Filed:
March 6, 2017
Date of Patent:
October 27, 2020
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Anna Tampieri, Monica Sandri, Simone Sprio
Abstract: A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, in the therapeutic treatment of paralysis caused by spinal cord injury.
Type:
Grant
Filed:
January 21, 2019
Date of Patent:
September 22, 2020
Assignee:
CONSIGLIO NAZIONALE DELLE RICERCHE
Inventors:
Sara Marinelli, Flaminia Pavone, Siro Luvisetto, Valentina Vacca
Abstract: The present invention relates to a zinc oxide-based piezoelectric device, utilizable both as a sensor and as an actuator. More in particular, the present invention relates to a piezoelectric device (1, 101) comprising at least two carbon fibre crossed yarns (2a, 2b; 102a, 102b), at the intersection of which a zinc oxide layer (3, 103) in nanorod form is arranged, wherein an end (4a, 4b) of each of said yarns (2a, 2b; 102a, 102b) is connected to an operative unit (5).
Type:
Grant
Filed:
March 12, 2015
Date of Patent:
August 11, 2020
Assignees:
Bercella S.r.l., CNR Consiglio Nazionale delle Ricerche
Inventors:
Davide Calestani, Nicola Coppede, Maurizio Culiolo, Davide Delmonte, Marco Lani, Andrea Zappetini, Laura Marchini, Rocco Bercella