Patents Assigned to CorMatrix Cardiovascular, Inc.
  • Patent number: 9308084
    Abstract: A prosthetic atrioventricular tissue valve comprising a continuous tubular member formed from a first biocompatible material, the tubular member having proximal and distal ends, and at least one valve leaflet formed therein, the distal end of the tubular member including cardiovascular structure engagement means for connecting the tubular member to a cardiovascular structure, the cardiovascular structure engagement means comprising a plurality of elongated members that extend distally from the distal end of the tubular member.
    Type: Grant
    Filed: March 29, 2014
    Date of Patent: April 12, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventor: Robert G Matheny
  • Patent number: 9308225
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: April 12, 2016
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9295758
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 29, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9289532
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 22, 2016
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9283302
    Abstract: A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: March 15, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9265798
    Abstract: Methods for treating a cardiovascular disorder comprising administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: February 23, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventor: Robert G Matheny
  • Patent number: 9265799
    Abstract: Methods for treating a cardiovascular disorder comprising administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: February 23, 2016
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9241789
    Abstract: Methods for forming extracellular matrix valve conduits are disclosed. Extracellular matrix valve conduits produced using the disclosed methods are also disclosed. Methods of sterilizing and decellularizing extracellular matrix materials are also disclosed.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: January 26, 2016
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Christian L Gilbert
  • Patent number: 9226821
    Abstract: Extracellular matrix (ECM) valve conduits are disclosed. Methods for regenerating atrioventricular valves to replace defective atrioventricular valves within a heart of a subject using the ECM valve conduits are also disclosed. Methods of sterilizing and decellularizing an ECM material are also disclosed.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: January 5, 2016
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: 9199001
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: December 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9161952
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: October 20, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventors: Robert G Matheny, Anna Fallon
  • Patent number: 9149496
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: October 6, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9132172
    Abstract: A method of retarding cellular senescence comprising (i) providing an extracellular matrix (ECM) composition comprising ECM from an adolescent tissue source, the ECM comprising an exogenously added cytokine, and (ii) administering ECM composition to an organ with cells exhibiting cellular senescence, wherein, the cytokine interacts with at least one molecule in the ECM composition and modulates ROS production of the cells, whereby, the cellular senescence is abated.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: September 15, 2015
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9125972
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: September 8, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9119899
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert Matheny
  • Patent number: 9119841
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: September 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9089549
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: July 28, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9084841
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: July 21, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Patent number: 9078873
    Abstract: Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: July 14, 2015
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 9072816
    Abstract: A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least one additional bioactive component selected from the group consisting of a statin and a chitin derivative.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 7, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert Matheny