Patents Assigned to Corvas International, Inc.
  • Patent number: 6872808
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: March 29, 2005
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Patent number: 6818616
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: November 16, 2004
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Patent number: 6777431
    Abstract: The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: August 17, 2004
    Assignee: Corvas International, Inc.
    Inventors: Daniel Vanna Siev, Joseph Edward Semple, Mallareddy Komandla, John Eugene Reiner, Scott Jeffrey Kemp
  • Patent number: 6756211
    Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: June 29, 2004
    Assignee: Corvas International, Inc.
    Inventors: Matthew Moyle, David L. Foster, George P. Vlasuk
  • Patent number: 6677473
    Abstract: Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones and benzophenones are provided.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: January 13, 2004
    Assignee: Corvas International INC
    Inventors: Edwin L. Madison, Terence K. Brunck, Joseph Edward Semple, Marguerita Lim-Wilby, Kent E. Pryor, Ronald D. Lewis, II, David F. Duncan, C. Maxwell Lawrence
  • Publication number: 20040001801
    Abstract: Conjugates, compositions and methods for treatment, prevention, or amelioration of one or more symptoms of cell surface protease-related diseases, including MTSP-related, urokinase-type plasminogen activator (uPA) or endotheliase-related diseases, are provided. The conjugates for use in the compositions and methods are peptidic conjugates that contain therapeutic, including cytotoxic, agents.
    Type: Application
    Filed: May 23, 2002
    Publication date: January 1, 2004
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Joseph Edward Semple, George P. Vlasuk, Scott Jeffrey Kemp, Mallareddy Komandla, Daniel Vanna Siev
  • Publication number: 20030235900
    Abstract: Provided herein are type II transmembrane serine protease 10 (MTSP10) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the activity of an MTSP10 are provided.
    Type: Application
    Filed: May 14, 2002
    Publication date: December 25, 2003
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Jiunn-Chern Yeh
  • Patent number: 6638977
    Abstract: Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers are provided.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: October 28, 2003
    Assignee: Corvas International, Inc.
    Inventors: Edwin L. Madison, Terence K. Brunck, Joseph Edward Semple, Marguerita Lim-Wilby, Kent E. Pryor
  • Publication number: 20030180804
    Abstract: The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.
    Type: Application
    Filed: October 29, 2002
    Publication date: September 25, 2003
    Applicant: Corvas International, Inc
    Inventors: Kent E. Pryor, Ronald D. Lewis, Jason W. Brown
  • Publication number: 20030181658
    Abstract: Provided herein are polypeptides designated CVSP14 polypeptides that exhibit protease activity as a single chain or as an activated two chain form. Methods using the polypeptides to identify compounds that modulate the protease activity thereof are provided. The polypeptides also serve as tumor markers.
    Type: Application
    Filed: March 20, 2002
    Publication date: September 25, 2003
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Jiunn-Chern Yeh
  • Publication number: 20030166851
    Abstract: Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP9 are provided.
    Type: Application
    Filed: March 27, 2002
    Publication date: September 4, 2003
    Applicant: Corvas international, Inc.
    Inventors: Edwin Madison, Edgar O. Ong
  • Patent number: 6608204
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: August 19, 2003
    Assignee: Corvas International, Inc.
    Inventor: Susan Yoshiko Tamura
  • Patent number: 6586405
    Abstract: Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: July 1, 2003
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Michael I. Weinhouse, Odile Esther Levy, Edwin L. Madison, Amir P. Tamiz
  • Publication number: 20030119168
    Abstract: Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided are MTSPs designated MTSP3 and MTSP4 and a form of an MTSP designated MTSP6.
    Type: Application
    Filed: February 2, 2001
    Publication date: June 26, 2003
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Edgar O. Ong, Jiunn-Chern Yeh
  • Patent number: 6576613
    Abstract: Novel inhibitors of urokinase are provided which have an arginine or arginine mimic aldehyde or an arginine ketoamide group at P1. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: June 10, 2003
    Assignee: Corvas International, Inc.
    Inventors: Terence K. Brunck, Susan Y. Tamura, Edwin L. Madison
  • Patent number: 6541467
    Abstract: The present invention provides compounds having a lactam ring at P3 and at P1 have a six-membered heterocyclic ring having two ring nitrogen ring atoms and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 1, 2003
    Assignee: Corvas International, Inc.
    Inventors: Jonathan Zhanqi Ho, Joseph Edward Semple
  • Patent number: 6534629
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 18, 2003
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Patent number: 6506761
    Abstract: Compound of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: as described herein.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Gian Luca Araldi, Joseph Edward Semple
  • Patent number: 6506754
    Abstract: The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the ring atoms carbon atoms at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Daniel Vanna Siev, Gian Luca Araldi, Jonathan Zhanqi Ho, John Eugene Reiner, Joseph Edward Semple
  • Patent number: 6506760
    Abstract: Compounds of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: as described herein.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Gian Luca Araldi, Joseph Edward Semple