Abstract: The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
Type:
Application
Filed:
April 23, 2004
Publication date:
February 24, 2005
Applicants:
Coley Pharmaceutical GmbH, University of Iowa Research Foundation, CPG Immunopharmaceuticals GMBH, Ottawa Health Research Institute
Inventors:
Heather Davis, Joachim Schorr, Arthur Krieg
Abstract: The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
Type:
Application
Filed:
May 9, 2003
Publication date:
December 4, 2003
Applicants:
Coley Pharmaceutical GmbH, University of Iowa Research Foundation, CPG Immunopharmaceuticals GMBH, Ottawa Health Research Institute
Inventors:
Heather L. Davis, Joachim Schorr, Arthur M. Krieg