Abstract: A compound is provided for inactivating viral, bacterial or other contamination in cells, body fluids or fractions thereof. The compound comprises a psoralen with a single substituent that is either a quaternary phosphonium or ammonium moiety, and at least one substituent that is a halogen. The compound selectively binds to the contaminant, and upon activation by irradiation, damages the contaminant.
Type:
Grant
Filed:
December 10, 1993
Date of Patent:
December 24, 1996
Assignee:
Credit Managers Association of California
Inventors:
Raymond P. Goodrich, Jr., Matthew S. Platz, Nagender Yerram, Roger W. Hackett, Marjan van Borssum Waalkes, Christine M. Williams-Hughes, Victoria A. Wong