Patents Assigned to Dade Behring Marburg GmbH
  • Patent number: 6531127
    Abstract: The invention relates to seroreactive regions on the E1 and E2 proteins of human papillomavirus 16 (HPV 16). The invention also relates to a vaccine that contains peptides comprising at least one seroreactive region of the E1 and/or E2 proteins. The invention likewise embraces compositions for diagnostic purposes, which contain peptides with the seroreactive regions. Further, the invention relates to antibodies that bind to seroreactive regions of the E1 and/or E2 proteins of HPV 16, and compositions comprising such antibodies, which can be used for diagnostic purposes.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: March 11, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Martin Müller, Lutz Gissmann
  • Patent number: 6531137
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: March 11, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht v. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6531587
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: March 11, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6528626
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: March 4, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht v. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Publication number: 20030027235
    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
    Type: Application
    Filed: September 27, 2002
    Publication date: February 6, 2003
    Applicant: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Carsten Schelp, Andreas Wiegand
  • Patent number: 6506344
    Abstract: A multi-cell rotor for an automatic analyzer for examining biological fluids includes measurement cells of different configurations and also chambers of different geometries, in identical or different configurations, which receive different volumes of fluid, arranged on the rotor and used for preparing for measurements. The chambers can fluidly communicate with one another.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 14, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Karl Fickenscher, Oliver Kube
  • Publication number: 20030003442
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 2, 2003
    Applicant: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Publication number: 20030003443
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 2, 2003
    Applicant: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6489309
    Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: December 3, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Rajendra Singh, Harshvardhan Mehta
  • Publication number: 20020172939
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Application
    Filed: June 22, 2001
    Publication date: November 21, 2002
    Applicant: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6482653
    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: November 19, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Carsten Schelp, Andreas Wiegand
  • Patent number: 6475717
    Abstract: The invention relates to a method for detecting and determining mediators and/or their derivatives in fluids, the mediator being detected directly or indirectly with the aid of a recombinant, soluble receptor for the mediator to be detected.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: November 5, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Karlheinz Enssle, Roland Kurrle, Klaus-Dieter Langner, Leander Lauffer, Josef-Urban Pauly, Friedrich-Robert Seiler
  • Publication number: 20020155428
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristics antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Application
    Filed: June 22, 2001
    Publication date: October 24, 2002
    Applicant: Dade Behring Marburg GmbH.
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6455288
    Abstract: The present invention relates to methods for immunoassay of analytes employing mutant glucose-6-phosphate dehydrogenase (G6PDH) enzymes as labels. In particular, the invention relates-to the use of conjugates of an analyte or analyte analog and a mutant NAD+ dependent G6PDH differing from any precursor G6PDH by the deletion, substitution, or insertion, or any combination thereof of at least one amino acid per subunit. The invention also involves the construction of several mutations in precursor glucose-6-phosphate dehydrogenase (G6PDH) enzymes. Typically, the mutations involve deletion or substitution of one or more lysine residues, or introduction of one or more cysteine residues by insertion of cysteine to precursor G6PDH or substitution of precursor G6PDH amino acids residues with cysteine.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: September 24, 2002
    Assignees: Dade Behring Marburg GmbH, Genencor International, Inc.
    Inventors: Edward Benjamin Jakobovits, Joy L. Silen, Mark J. Levy, Thomas C. Goodman, Martin Becker, Edwin F. Ullman, Robert M. Caldwell, Richard R. Bott, Christopher Charles Barnett
  • Patent number: 6451311
    Abstract: The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free calcitonin, free katacalcin and free N-procalcitonin.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: September 17, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Harald Althaus, Götz Walter
  • Patent number: 6447728
    Abstract: An exchangeable oscillating pipette needle for an automatic analyzer for examining biological body fluids is provided, in which the analyzer has a holder provided with a tension spring, and with which the oscillating arm, carrying the pipette needle and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: September 10, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Hugo Wilmes, Oliver Kube
  • Patent number: 6440747
    Abstract: The present invention relates to the use of sterol esters for the long-term stabilization of biological fluids, in particular even those which are obtained by lyophilization and subsequent reconstitution.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: August 27, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventor: Harald Althaus
  • Patent number: 6441141
    Abstract: The present invention is directed to the generation of antibodies which preferentially bind to fibrinogen fragments E1, E2 and E3, but exhibit little or no cross-reactivity against fibrin monomer and fibrinogen. Thus, the invention provides synthetic peptides containing defined amino acid sequences corresponding to the carboxy terminal regions of the E fragments which arise as a result of plasmin cleavage of fibrin and fibrinogen. The synthetic peptides may be synthesized chemically, or through genetic manipulations, and may contain additional amino acid sequences which are not contiguous with the defined E fragment sequences.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: August 27, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Werner Stüber
  • Patent number: 6426204
    Abstract: A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. Also disclosed are methods for determining D-arabinitol. In one embodiment the method comprises the steps of providing in combination (1) a medium suspected of containing D-arabinitol and (2) a D-arabinitol dehydrogenase enzyme and examining the medium for the product of the oxidation of the D-arabinitol. The enzyme utilized is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol. Kits for conducting the present method are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 30, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Charles Garrett Miyada, Arthur C. Switchenko, Melanie W Quong, Man-Ying Laurie Wong
  • Patent number: 6419925
    Abstract: The present invention relates to the identification of toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were identified using a high-titer rabbit anti-Toxoplasma gondii serum, and isolated.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: July 16, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Stefan Knapp, Robert Ziegelmaier, Hans Küpper