Patents Assigned to Dade Behring Marburg GmbH
  • Patent number: 6221577
    Abstract: The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 24, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Martin Müller, Lutz Gissmann
  • Patent number: 6214626
    Abstract: An apparatus which permits simultaneous use as reaction vessel for taking up one or more reaction liquids, for incubating and storing these liquids and for carrying out optical measurements is described. The apparatus performs functions of the reaction vessel and functions of the apparatus for liquid uptake. This makes it possible for analysis to be completely free of carryover while, at the same time, requiring minimal use of consumable materials or rinsing solutions.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: April 10, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Paul Meller, Jürgen Gross
  • Patent number: 6211344
    Abstract: The invention relates to a process for preparing factor V-deficient plasma, in particular a factor V-deficient plasma from a starting plasma using antibodies, and a deficient plasma which is obtained in this way.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: April 3, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Erika Aillaud, Heinz-Hermann Drescher
  • Patent number: 6210908
    Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: April 3, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael E. Annunziato, Paul S. Palumbo
  • Patent number: 6201109
    Abstract: This invention relates to novel monoclonal antibodies XI-4G6, XII-10E3 and XII-3B2, which are capable of recognizing bone alkaline phosphatase and not liver alkaline phosphatase. Methods and kits for using these antibodies in the determination of bone alkaline phosphatase are also described.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: March 13, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Zafrira Avnur, Suzanna S. Pedersen, Mary Jane Cerelli, Thomas D. Kempe
  • Patent number: 6198950
    Abstract: The present invention relates to an implantable diagnostic apparatus for determining analytes in body fluids, which comprises a plurality of identical and/or different measurement units for determining an analytic parameter, in which a signal is generated which is specifically related to the variable to be determined and is transmitted by means of suitable measures to a receiver situated outside the body.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: March 6, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventor: Michael Kraus
  • Patent number: 6194214
    Abstract: The invention relates to a process for the production of plasmas with added annexins for use as a control or standard in all functional clotting tests which are used for the detection of a lupus anticoagulant.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: February 27, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventor: Michael Kraus
  • Patent number: 6190873
    Abstract: A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is also disclosed. Compositions wherein cyclosporin is conjugated to an immunogenic carrier or a label, optionally through a linking group, at an alanine nitrogen atom of the cyclic backbone of cyclosporin are also disclosed. Compositions wherein atiocyclosporin is conjugated, optionally through a linking group, to an immunogenic carrier or a label are also disclosed. Where cyclosporin is conjugated to an immunogenic carrier, the conjugates may be used as immunogens for the preparation of antibodies which are capable of recognizing cyclosporin.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: February 20, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Dariush Davalian, Maureen H. Beresini, Svetlana Alexander, Mae Wan-Leng Hu, Edwin F. Ullman
  • Patent number: 6187594
    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: February 13, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Carsten Schelp, Andreas Wiegand
  • Patent number: 6183980
    Abstract: The present invention relates to a method for identification of defects in the clotting, fibrinolysis and complement system.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: February 6, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Annelie Siegemund, Thomas Siegemund
  • Patent number: 6180354
    Abstract: Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 30, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Sharat Singh, Edwin F. Ullman
  • Patent number: 6171801
    Abstract: One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement in a method for the determination of an analyte that is a member of a specific binding pair in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a compound of the invention in an amount sufficient to enhance the accuracy of the determination. The invention has particular application to a method for releasing mycophenolic acid from a complex thereof.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 9, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Mark A. Staples, Carolyn J. Haley, Richard F. Parrish, Wesley W. Zmolek
  • Patent number: 6160097
    Abstract: A process is described for reactivating purified membrane proteins in which a mixture composed of membrane protein, a phospholipid and a detergent is frozen and subsequently thawed.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: December 12, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventor: Norbert F. Zander
  • Patent number: 6159698
    Abstract: One aspect of the present invention relates to assays for the detection of mycophenolic acid. The method comprises including in an assay medium suspected of containing mycophenolic acid a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. Another aspect of the present invention is an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in combination in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: December 12, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventors: Mark A. Staples, Richard F. Parrish
  • Patent number: 6143493
    Abstract: The invention relates to peptides for the immunochemical determination of human cytomegalovirus (HCMV)-specific antibodies and HCMV antigens, and to agents suitable for this method and to the use thereof.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 7, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventors: Werner Stuber, Leszek Wieczorek, Robert Ziegelmaier
  • Patent number: 6143575
    Abstract: The invention relates to a method for carrying out heterogeneous immunoassays, in particular to a method for separating a coated solid phase from a liquid phase by means of precipitation and subsequent centrifugation, with a detectable activity remaining in the liquid phase.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: November 7, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventor: Michael Kraus
  • Patent number: 6143514
    Abstract: Compositions, methods and kits are disclosed. The compositions comprise a matrix having incorporated therein a label capable of being modified by singlet oxygen. A catalyst capable of catalyzing the formation of singlet oxygen is bound to the matrix, which permits the diffusion of singlet oxygen therein. The compositions may be used in methods for detecting hydrogen peroxide or a compound capable of generating hydrogen peroxide. A sample suspected of containing such compound is combined with a composition in accordance with the present invention. The combination is subjected to conditions wherein such compound generates hydrogen peroxide. The reaction of singlet oxygen with the label is determined, the reaction thereof indicating the presence of the compound capable of generating hydrogen peroxide.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: November 7, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventors: Edwin F. Ullman, Sharat Singh
  • Patent number: 6127164
    Abstract: The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing those tumors (oral, genital and cutaneous tumors) which are associated with HPV 57.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 3, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventors: Ethel-Michele de Villiers, Anja Hirsch-Behnam, Harald zur Hausen
  • Patent number: 6127111
    Abstract: The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an anticoagulant, an cake forming agent ad an inhibitor of platelet function selected from the group consisting of chloroquine, hydroxychloroquine, camoquin, quinacrine and procaine is disclosed.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: October 3, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventor: Konrad Braun
  • Patent number: 6120990
    Abstract: The present invention is directed to an immunochemical method for qualitatively or quantitatively detecting an analyte in which a first and a second binding component are contacted with the analyte, followed by detection of the binding of the binding components to the analyte. According to the invention, both of the binding components are prepared recombinantly in the same host using different vectors (V1 and V2) for expressing fusion proteins, with the first binding component being expressed as a fusion protein F1 in vector V1 and the second binding component being expressed as a fusion protein F2 in vector V2. The novel method, which can also be employed for simultaneously determining several analytes, is more sensitive and specific than prior known methods.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: September 19, 2000
    Assignee: Dade Behring Marburg GmbH
    Inventors: Stefan Brust, Hans-Peter Hauser, Stefan Knapp, Helmut Peters