Abstract: Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.

Abstract: The present invention concerns a medical pump comprising: a. A hard housing comprising a top (24) and bottom (1) hard shells, within which a rigid wall (3) and a movable membrane (2) create three distinct chambers; wherein i. said movable membrane tightly separates said second (29) and third (22) chambers ii. said first and third chambers have a watertight interface iii. said second chamber (29) is designed to contain a fluid iv. said first chamber (23) comprises a first venting mean (20) which is arranged to provide a fluidic communication between said first chamber (23) and the external environment; v. said third chamber (22) comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber (22) and the external environment b. A pumping element (4) located in the first chamber (23) c. A least one pressure sensor which measure the pressure gradient between the first chamber (23) and the second chamber (29) d. A fluid pathway which permits: i.

Abstract: The invention relates to a device comprising a wafer comprising a silicon area and a wafer comprising a glass area fastened to each other, the fastening zone thus formed between the wafers defining a multilayer structure comprising a first layer protecting the silicon from physical changes caused by attack of the surface, which layer covers the silicon area, and a second layer protecting the glass from physical changes caused by attack of the surface, which layer covers the glass area; said multilayer structure furthermore comprising at least one additional layer enabling anodic bonding between the two protective layers; said device containing at least one fluid channel protected by said protective layers and able to contain a solution temporarily.

Abstract: The invention relates to a method for prescribing a dialysis treatment comprising the following steps: collecting patient specific data, determining at least one target, defining a series of values of the type [V;t] which allow to achieve said target wherein V represents the volume of dialysate used and t the duration of treatment, based on said patient specific data, displaying said series of values on a map. The invention also relates to a system using this method.

Abstract: Cannula inserter comprising a casing with a distal end, intended to be placed in proximity to the skin of a patient, and an opposite proximal end, a piston fixed at least temporarily by retaining means, drive means designed to exert a propulsion force of the piston in the direction counter to the trigger, and release means intended to release the piston; the inserter additionally comprising a needle fixed to a support; the piston being mounted in the casing in such a way that, once released, it reaches and remains temporarily in a first position, then a second position; the needle and its support also being arranged so as to be able to be driven by the piston in a direction corresponding to the main orientation of the casing, before the piston reaches said first position, and so as to be able to effect an automatic rotation about an axis perpendicular to said main orientation during the movement of the piston between said first position and said second position.

Abstract: The invention concerns a system and a method of use of said system for performing fluid administration on a patient, the system comprising a liquid pump, a liquid distribution system, a liquid supply means, and patient conduit. The liquid distribution system comprises two distinct hub chambers. The first hub chamber includes at least one liquid supply port with a dedicated valve means, one patient port with dedicated valve means, and one pump inlet. The second hub chamber includes at least one patient port or warmer port with dedicated valve means and one pump outlet. The system further comprises control means arranged to close the patient port of the first hub chamber when the liquid supply port is open, and vice versa.

Abstract: A method for actuating a pumping device with an optimal driving voltage, wherein the pumping device comprises a pumping chamber (4) having a pumping membrane (1), an inlet (3) and an outlet chamber (5), a voltage controlled actuator (6) connected to said pumping membrane (1), said pumping membrane reaching a stop position defined by a mechanical stop (2) a sensor for determining whether the pumping membrane has reached said mechanical stop (2); said method comprising a learning and working phase, wherein the learning phase comprises the following steps actuation of the pumping membrane (1) by applying a predetermined actuation voltage Vact to the actuator (6) said pumping membrane (1) reaching said position in an over-actuation step or not reaching said mechanical stop (2) position in an under-actuation process; after the over-actuation step, decreasing the voltage so that the pumping membrane (1) has left said mechanical stop (2) position and storing as the optimal voltage Vact optimal or in the under-actuat

Abstract: A fluid flow regulator (1) of the passive type is disclosed which has a fluid inlet adapted to be connected to a fluid reservoir and a fluid outlet (13) adapted to be connected to a patient's body. The regulator comprises a rigid substrate (2) and a resilient membrane (3) tightly linked together so as to define a cavity (6) there between which is disconnected to the fluid outlet while the membrane has a first surface (12) opposite the cavity which is connected to the fluid inlet. The membrane has a plurality of through holes (15) contiguous with the cavity, to define a pathway for a fluid from the fluid inlet to the fluid outlet, and is flexible so as to be able to come into contact with the substrate as a fluid applies a sufficient pressure on the first surface.

Abstract: System for inputting and displaying data comprising a programming screen, means for inputting data and means for displaying said data on said screen, characterized in that it comprises furthermore a series of indicators and means for activating said indicators which are adapted in such a way as to activate and to associate a specific indicator for each type of data to be input.

Abstract: An out-of-plane microneedle manufacturing process comprises the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat above each microneedle under formation. The process comprises the following steps: providing bridges between the hats, maintaining the bridges during the remaining microneedle manufacturing steps, removing the bridges, together with the hats, when the microneedles are formed.

Abstract: The invention relates to a peritoneal dialysis sampling system to be used together with a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity, said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity, said peritoneal dialysis sampling system comprising an automatic sampling system which is able to automatically sample volumic fractions of the dialysate contained in the peritoneum of the patient at specific time intervals in order to evaluate the peritoneal membrane characteristics and/or improve the peritoneal dialysis for a given patient.

Abstract: The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps:—providing a support having a surface,—depositing on the surface one mono-layer of temporary particles,—depositing a coating on the temporary particles in such a way that the thickness of the coating is less than the particle diameter,—eliminating the temporary particles and thereby obtaining a porous coating, the pores of the coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment,—applying a coating fixation step, characterized by the fact that it furthermore comprise a filling step where the pores are at least partially filled with a liquid or solid substance. The invention also concerns a coating and an object which can be obtained with this process.

Abstract: Medical liquid injection device comprising the following distinct elements: a container (1), an outlet channel (14) and a pumping unit (5); said container (1) comprising a rigid wall on which said pumping unit (5) is rigidly fixed; said rigid wall furthermore including a passage (4) which forms a direct fluid connection between said pumping unit (5) and said container (1); said outlet channel (14) being directly connected to said pumping unit (5) in such a way that a fluid initially kept in said container (1) may first flow through said pumping unit (5) and then reach said outlet channel (14), said medical liquid injection device furthermore comprising an inlet (16), distinct from said outlet channel (14), and disposable elements.

Abstract: A peristaltic pumping system comprises a flexible tube, a substantially cylindrical rotating roller unit containing a series of rollers which are freely rotating around their axes and freely moving along a radial segment, holding mechanism for commonly holding the rollers, a central spreader element for pushing the rollers against the flexible tube and a driving unit comprising a driving coupling element, and the holding mechanism is made of at least one planar element having retaining and guiding means for rollers, and the planar element is furthermore adapted to be directly coupled to the coupling element in such a way that rollers are driven through the planar element.

Abstract: The invention relates to a drug delivery device (1, 100), in particular for the delivery of drugs comprising molecules tending to spontaneously form nucleation seeds leading to fibrils, comprising a drug reservoir (2, 102) having a reservoir outlet (107) connected to a device outlet, adapted to deliver a drug fluid to a patient's body, through a pathway (5) including a fluid flow controlling system (4, 104). The pathway further includes a filtration module (6, 106) adapted to retain the nucleation seeds, preferably by forcing them through a filtering membrane pores and on the basis of hydrophobic interaction with the membrane.

Abstract: Element comprising a substrate and a nanoporous adherent coating made of at least one layer, said layer being in adherent contact with said substrate and comprising separate domains of nanoparticles, each of said domains having an average diameter between 1 and 1000 nm and being separated from its neighbor domains on the major part of its circumference by an average distance equal or less to its diameter.

Abstract: A micro-needle (4) comprising a sharp tip (31), an elongated body (32) and a head (36) containing at least two parallel independent lumens (5,6), each of said lumens (5,6) communicating with a distal side opening (7,8) of the head (36); said openings (7,8) being essentially oriented in a direction which is perpendicular with respect to its lumen (5,6) main direction and wherein the distal top end (33,34) of said lumen (5,6) is in the head (36) of the micro-needle (4).

Abstract: The invention relates to a method for prescribing a dialysis treatment comprising the following steps: collecting patient specific data, determining at least one target, defining a series of values of the type [V;t] which allow to achieve said target wherein V represents the volume of dialysate used and t the duration of treatment, based on said patient specific data, displaying said series of values on a map. The invention also relates to a system using this method.

Abstract: The regulator comprises at least a cylinder (2) with a fluid inlet connector (1) for receiving fluid at an inlet pressure and a fluid outlet connector (4) for delivering fluid, at least one chamber (3), a rod (5) in said cylinder with one side submitted to the inlet pressure and the other side submitted to the outlet pressure generating a net force counter-balanced by at least one spring means (7) acting on one side of said rod (5) against said inlet pressure, wherein a fluidic pathway is formed between said rod (5) and said cylinder (2) as the major fluidic resistance of the device, wherein a change of the inlet pressure induces a move of the rod along the axis of the cylinder thereby modifying the fluidic resistance of said fluidic pathway, wherein the fluidic resistance of said pathway varies with the applied pressure at the inlet in a predefined range of pressure, inducing a regulated flow rate in the considered range of pressure.

Abstract: Device for determining the characteristics of peritoneal membrane comprising means for measuring glucose in the fluid drainage and a processing unit comprising means for determining the characteristics of the membrane as a function of that rate of glucose measured at different times. The invention also relates to a method for determining the characteristics of peritoneal membrane including the consideration of glucose measured at different moments in the liquid drainage.