Abstract: A sensor pixel detects a photon and outputs a first voltage proportional to a time of arrival of the detected photon. This voltage is converted to a multi-bit digital signal in the format of a thermometer code. A number of counter circuits, one counter circuit per bit of the multi-bit digital signal, are provided to accumulate the thermometer coded outputs. Each counter is configured to increment in response to an active logic state of the corresponding bit of the multi-bit digital signal. Accumulated count values in the counter circuits provide a timing histogram with respect to photon detection.

Abstract: The present invention is directed to compounds and pharmaceutically acceptable salts thereof which are inhibitors of the activity or function of the phosphoinositide 3?OH kinase family (hereinafter PI3K) for use in the treatment or prevention of respiratory infections, the treatment of airway damage, and/or the prevention of airway injury in patients with a PI3K? mutation.

Abstract: Provided is a method of inducing transdifferentiation of mesenchymal stem cells (MSC), the method including (a) culturing MSC in a first culture medium including a growth factor selected for allowing formation of neuralized MSC (NMSC); (b) allowing the NMSC to proliferate for a sufficient time during which said culture medium is renewed at least once; and (c) culturing the NMSC of (b) in a second culture media including cerebrospinal fluid (CSF) for a time sufficient for the NMSC to differentiate into a population of cells including terminally differentiated neurons, astrocytes and oligodendrocytes. Also provided by the present invention is the use of MSC or NMSC for providing a composition including said population and to kits including MSC or NMSC and instructions for use of same.

Abstract: A lighting system includes a light emitting diode array, and a time of flight ranging system. A logic circuit determines a distance to an object using the time of flight ranging system and controls the light emitting diode array based upon the distance to the object. A receptacle is coupled to the logic circuit, and sized and configured to fit within and be powered from a light bulb socket. In some applications, the logic circuit may activate the light emitting diode array when the object is less than a threshold distance away from the lighting system and deactivate the light emitting diode array when the object is greater than the threshold distance away from the lighting system. In further applications, the logic circuit may activate the light emitting diode array at a duty cycle that varies based upon the distance to the object.

Abstract: In various embodiments, an exemplary system for viewing a content object through a web-based interface comprises a content object management module, an import/export module, a conversion module, and a GUI module. The content object management module may be configured to manage storage of the content object in the system. The import/export module may be configured to receive the content object from a database or an application external to the system, index the content object for viewing access by a user, and provide the computer readable material to the content object management module for management. The conversion module may be configured to convert the content object, received through the importation module, from a native format to a format viewable by the user through the system. The GUI module may be configured to present the content object to the user, through the web-based interface, in the viewable format.

Abstract: Multi-functional connection device attached to the end of a telescopic pole for facilitating connection and disconnection of the pole and a maintenance tool with a handle having a standard V-clip or alternative clip. The connection device has two opposing flexible arms used to push down the pins of the tool handle when disconnecting the tool handle from the pole and has two opposing tapered ramps at the rim capable of pushing down the pins of the tool handle when connecting the tool handle to the pole.

Abstract: A grease trap (1) device for trapping waste material including water and fats, oils and/or greases (FOGs), and for removing at least some of the FOGs from the water. The device includes a first receptacle (3) having a storage volume (31) for storing waste material in a manner that enables FOGs to float on the surface of the water; an inlet (9) for receiving waste material into the first receptacle; a drain (49) having an inlet (47) positioned to capture FOGs floating at and/or near the surface of the water, and an outlet (51) positioned for transferring waste material out of the storage volume; a valve (53) for controlling the flow of waste material through the drain; an outlet (15) enabling cleaned water to exit the first receptacle; and at least one heat exchanger unit (57,59) arranged to remove heat from the waste material stored in the first receptacle.

Abstract: A module operates in a proximity detection mode and a gesture detection mode. The module includes an illumination source, radiation sensors and a controller. When in proximity detection mode, the illumination source emits radiation, the radiation sensors measure the radiation level, and the controller adjusts the measured radiation level to substantially cancel the contribution attributable to ambient radiation to determine the presence of a proximate object by. When in the gesture recognition mode, the level of radiation incident on the sensors is individually sampled, and the controller determines object movement by comparing the changes in the measured radiation levels over a plurality of the samples. Ambient radiation contribution is not removed from the sampled radiation levels during the gesture recognition mode.

Abstract: An autofocus method determines that a ranging device of a digital camera has failed in an attempt to provide a distance estimation. The ranging device provides one or more parameters indicating conditions related to the failure of the ranging device to provide the distance estimation. An autofocus sequence based on the one or more parameters is then performed.

Abstract: A camera module has a lens module mounted on a substrate. The image sensor is located in a cavity in the substrate and is connected to the substrate by a bridge member, the infra-red filter. The image sensor is attached to the infra-red filter by a ring of adhesive surrounding the imaging area of the image sensor. The adhesive attaching the image sensor to the infra-red filter comprises spacers. The infra-red filter is attached to the substrate by adhesive. The cavity may extend through the substrate. The image sensor is further connected to the substrate by a sheet member, which may be made of metal. The sheet member is affixed to the bottom of the substrate and covers the hole in the substrate formed by the extension of the cavity through the substrate. A method of assembly of the camera module includes: providing a substrate with a cavity; locating the image sensor in the cavity; connecting the infra-red filter to the image sensor and the substrate; and mounting the lens module on the substrate.

Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.

Abstract: A mechanical fault indicator of the automatic reset includes the core, the dial, the lock, the indicating rods, and the shell. The core includes the clip-on core, fixed core, connecting core and movable iron core. The pointer includes the indicating axis of rotation, the pointer connection and the indicating rod. The lock includes the lock axis of rotation, the lock hook and balancing weight. When using the indicator, clip the wire of the transmission line into the two-part clip-on core. When a short circuit fault happens, the indicating rod falls out of the housing, of which the action indicates failure. When the circuit is back to normal, the indicating rod resets automatically. The indicator has the advantages of: low cost, long service life, purely mechanical, no circuit and battery, and the installation is simple and convenient.

Abstract: This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung c

Abstract: An autofocus method determines that a ranging device of a digital camera has failed in an attempt to provide a distance estimation. The ranging device provides one or more parameters indicating conditions related to the failure of the ranging device to provide the distance estimation. An autofocus sequence based on the one or more parameters is then performed.

Abstract: A package includes a first die and a second die. The dies are connected to each other through an interface. At least one of the first and second dies includes a plurality of signal sources, wherein each source has at least one quality of service parameter associated therewith, and a plurality of queues having a different priorities. A signal from a respective one of the signal sources is allocated to one of the plurality of queues in dependence on the at least one quality of service parameter associated with the respective signal source. The interface is configured such that signals from said queues are transported from one of said first and second dies to the other of said first and second dies.

Abstract: A sensor system includes an array of pixels, each pixel including a first pixel and a second pixel. A first color filter provided over the first pixel is configured to pass a first color portion within and less than a visible portion of the spectrum. An infra-red color filter provided over the second pixel is configured to pass a near infra-red portion and an infra-red portion of the spectrum, but not the visible portion of the spectrum. An interference filter is provided over the first and second pixels, wherein the interference filter is configured to pass the visible portion of the spectrum and the near infra-red portion of the spectrum. The first pixel detects light sensed in the first color portion and the second pixel detects light sensed in the near infra-red portion. A processing circuit corrects the sensed first color portion as a function of the sensed near-infra-red portion.

Abstract: Disclosed in the present invention are a combustion furnace with coaxial staged hearth and heating method thereof, in which the combustion furnace comprises a metal furnace body (40) whose internal part is provided with a furnace chamber. The furnace chamber is divided into two sections at the middle by fire resistant material to form a left and a right independent combustion chambers (18, 19). Two independent combustion chambers (18, 19) are respectively connected with the ends of flue gas chambers (2, 60), while the other ends of the flue gas chambers (2, 60) are respectively connected with a burner (3). The peripherals of two independent combustion chambers (18, 19) are respectively provided with a flue gas heat radiation pipe (14). A middle flue gas chamber (100) is set in the middle position of the furnace chamber. Two ends of the flue gas heat radiation pipe (14) are respectively connected with the flue gas chamber (2, 60) and the middle flue gas chamber (100).

Abstract: A pharmaceutical composition comprises an active ingredient dissolved in an essentially non-aqueous carrier system comprising volatile and non-volatile components, in which the volatile component comprises a volatile non-solvent for the active ingredient and a volatile solvation additive for the non-solvent and the non-volatile component comprises a non-volatile non-solvent and optionally a non-volatile solvent for the active ingredient, the volatile and non-volatile non-solvents comprising silicone fluids of respectively different viscosity.