Patents Assigned to DKFZ Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
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Patent number: 8598126Abstract: The present invention is concerned with means and methods for diagnosing or treating HPV associated neoplasia or tumors. Specifically, it relates to a peptide comprising an amino acid sequence motif as shown in SEQ ID No: 1. Moreover, contemplated by the present invention are fusion polypeptides, polynucleotides, vectors and host cells based on said peptide. Furthermore, the peptides, fusion polypeptides, polynucleotides, and vectors are suitable as pharmaceutical compositions for treating HPV associated neoplasia or tumors. The peptides and fusion polypeptides are also suitable as diagnostic compositions for diagnosing HPV associated neoplasia or tumors. The present invention also refers to a method of identifying a compound capable of binding to the HPV E6 protein. Finally, a kit is provided for carrying out the aforementioned diagnosis or compound identification.Type: GrantFiled: April 7, 2009Date of Patent: December 3, 2013Assignee: DKFZ Deutsches Krebsforschungszentrum, Stiftung des offentlichen RechtsInventors: Felix Hoppe-Seyler, Karin Hoppe-Seyler, Susanne Kintscher
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Patent number: 8568994Abstract: The invention discloses a method of prenatal diagnosis comprising the step of isolating exosomes from an isolated fluid, wherein the exosomes are identified by biomarker detection. Furthermore, the invention discloses the isolation of exosomes from an isolated fluid and the use of a biomarker, particularly CD24 to isolate exosomes from an isolated fluid.Type: GrantFiled: August 1, 2008Date of Patent: October 29, 2013Assignee: DKFZ Deutsches Krebsforschungszentrum, Stiftung des Offentlichen RechtsInventors: Peter Altevogt, Sascha Keller
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Patent number: 8361955Abstract: The present invention is concerned with the therapy of neuroblastoma and related diseases. Specifically, the present invention relates to a method for treating or preventing neuroblastoma comprising administering to a subject a therapeutically effective amount of bone morphogenetic protein 4 (BMP4). Preferably, said BMP4 is applied together with chemotherapy and/or radiation therapy.Type: GrantFiled: February 4, 2009Date of Patent: January 29, 2013Assignee: DKFZ Deutsches Krebsforschungszentrum, Stiftung des Offentlichen RechtsInventors: Hedwig Elisabeth Deubzer, Olaf Witt
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Patent number: 8219325Abstract: The invention relates to a method for determining the ratio of two distinct target-peptides or polynucleic acids comprising: a) obtaining a sample containing said two distinct target-peptides or polynucleic acids, b) providing a precursor-peptide or precursor-polynucleic acid, comprising the two distinct target-peptides or -polynucleic acids in a known ratio, wherein the two distinct target-peptides or -polynucleic acids are connected by a cleavage site, c) cleaving the precursor-peptide or precursor-polynucleic acid at the cleavage site to obtain a standard with the known ratio of the two distinct target-peptides or -polynucleic acids, d) detecting a signal of each distinct target-peptide or -polynucleic acid of the standard in an analyzer, comparing the signals with the known ratio and determining a correction factor, e) detecting the signal of each distinct target-peptide or -polynucleic acid of the sample in the analyzer and f) determining the ratio of the two distinct target-peptides or -polynucleic acidType: GrantFiled: April 25, 2007Date of Patent: July 10, 2012Assignee: DKFZ Deutsches Krebsforschungszentrum Stiftung Des Offentlichen RechtsInventor: Wolf Dieter Lehmann
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Patent number: 8202694Abstract: The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.Type: GrantFiled: August 26, 2008Date of Patent: June 19, 2012Assignee: DKFZ Deutsches Krebsforschungszentrum Stiftung des Öffentlichen RechtsInventors: Markus Schmitt, Tim Waterboer, Michael Pawlita
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Publication number: 20120107797Abstract: The present invention is concerned with the provision of diagnostic means and methods. Specifically, it relates to a composition comprising oligonucleotides selected from at least two different groups of oligonucleotides, said groups comprising at least one pair of oligonucleotides being capable of specifically amplifying polynucleotides comprised by a Bovine Papillomavirus (BPV), said BPV being selected from the group consisting of BPV-1, BPV-2, BPV-3, BPV-4, BPV-5, BPV-6, BPV-7, BPV-8, BPV-9, BPV-10, and BAPV-11 as well as uses based on said composition and kits comprising it. Moreover, contemplated is a method for the simultaneous detection and/or identification of BPV types in a sample.Type: ApplicationFiled: March 17, 2010Publication date: May 3, 2012Applicant: DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES OFFENTLICHEN RECHTSInventors: Markus Schmitt, Martin Müller
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ASSEMBLY OF ABSOLUTELY QUANTIFIED PEPTIDE AND PHOSPHOPEPTIDE SOLUTIONS VIA ELEMENT MASS SPECTROMETRY
Publication number: 20120003680Abstract: The present invention relates generally to the fields of analytics of proteins and peptides. More particularly, the invention concerns generation of an absolutely quantified reference peptide or protein solution via element mass spectrometry. Furthermore, the invention relates to the absolute quantification of phosphopeptides and peptides by the use of an absolutely quantified peptide solution.Type: ApplicationFiled: January 11, 2010Publication date: January 5, 2012Applicant: DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÕFFENTLICHEN RECHTSInventors: Wolf Dieter Lehmann, Nico Zinn, Bettina Hahn -
Patent number: 8041414Abstract: The invention relates to a dual-modality imaging system and a method for dual-modality imaging of an imaged object, wherein a magnetic resonance imaging (MRI) apparatus for acquiring MRI data and at least one optical imaging detector for acquiring optical imaging data are arranged to acquire the MRI data and the optical imaging data of the imaged object (10) simultaneously, the at least one optical imaging detector being a non-contact optical imaging detector.Type: GrantFiled: September 4, 2007Date of Patent: October 18, 2011Assignee: DKFZ Deutsches Krebsforschungszentrum Stiftung Des Offentlichen RechtsInventors: Joerg Peter, Michael Bock, Reiner Umathum
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Publication number: 20110201560Abstract: The present invention is concerned with means and methods for diagnosing or treating HPV associated neoplasia or tumors. Specifically, it relates to a peptide comprising an amino acid sequence motif as shown in SEQ ID No: 1. Moreover, contemplated by the present invention are fusion polypeptides, polynucleotides, vectors and host cells based on said peptide. Furthermore, the peptides, fusion polypeptides, polynucleotides, and vectors are suitable as pharmaceutical compositions for treating HPV associated neoplasia or tumors. The peptides and fusion polypeptides are also suitable as diagnostic compositions for diagnosing HPV associated neoplasia or tumors. The present invention also refers to a method of identifying a compound capable of binding to the HPV E6 protein. Finally, a kit is provided for carrying out the aforementioned diagnosis or compound identification.Type: ApplicationFiled: April 7, 2009Publication date: August 18, 2011Applicant: DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES OFFENTLICHEN RECHTSInventors: Felix Hoppe-Seyler, Karin Hoppe-Seyler, Susanne Kintscher
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Publication number: 20110020334Abstract: The present invention is concerned with the therapy of neuroblastoma and related diseases. Specifically, the present invention relates to a method for treating or preventing neuroblastoma comprising administering to a subject a therapeutically effective amount of bone morphogenetic protein 4 (BMP4). Preferably, said BMP4 is applied together with chemotherapy and/or radiation therapy.Type: ApplicationFiled: February 4, 2009Publication date: January 27, 2011Applicant: DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTSInventors: Hedwig Elisabeth Deubzer, Olaf Witt