Abstract: The present disclosure relates to a pharmaceutical composition containing an inhibitor against the expression or activation of a novel ADP-ribosyl cyclase or a naturally occurring variant thereof as an active ingredient for preventing or treating an ADP-ribosyl cyclase-mediated disease. In addition, the present disclosure relates to a composition for diagnosis of an ADP-ribosyl cyclase-mediated disease, the composition containing an agent for measuring a gene expression level or protein level of the ADP-ribosyl cyclase or a naturally occurring variant thereof. The composition of the present disclosure has the effect of inhibiting calcium increase in kidney cells, which is attributed to angiotensin II-induced ADP-ribosyl cyclase expression or activation, and as such can be advantageously used as a therapeutic agent for an ADP-ribosyl cyclase-mediated disease, particularly a renal disease.

Abstract: A coating sheet for preventing adhesion of advertising materials includes a soft sheet made with a synthetic resin; a protective layer formed on one of the two surfaces of the soft sheet to protect the sheet from decoloration by the ultra-violet rays in the sunlight; a first coating layer formed on the protective layer and provided with a plurality of small projections; a second coating layer formed as a film on the first coating layer; an adhesive layer formed on the opposite side of the soft sheet for attaching the soft sheet; and a release paper layer positioned underside (exposed surface of) the adhesive layer to protect the adhesive layer from being contaminated by foreign materials and losing adhesive power. The coating sheet can be attached to public or private installation, such as walls, poles, street lights, or traffic lights, to prevent adhesion of unlawful advertising materials on the installation.