Patents Assigned to Drug Delivery Systems Inc.
  • Patent number: 4878892
    Abstract: The invention comprises in combination:(a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and(b) an electrolytic device for transdermal transport of the polypeptide to the bloodstrem of the patient.It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants.The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patient's skin.Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: November 7, 1989
    Assignee: Drug Delivery Systems Inc.
    Inventors: Dan Sibalis, Sanford Rosen
  • Patent number: 4865582
    Abstract: A transdermal drug applicator for application to the skin or membrane of a patient and which is electrically powered. The applicator includes a flexible, non-conductive substrate having a plurality of conductive coated areas. The conductive coated areas include drug reservoir electrodes. The flexible substrate and the conductive coated areas form a single, substantially flat, flexible member. A plurality of separate drug reservoirs are in electrical contact with the drug reservoir electrodes. At least one battery is connected in series with the drug reservoir electrodes. The flexible substrate has opposed flat surfaces, the electrically conductive coated areas being electrically conductive coated areas on the flat surrfaces. Electrical connection between the conductive coated areas in the vicinity of each reservoir is provided by electrically conductive material extending into a single hole, small holes, or slots which extend between the opposed surfaces of the substrate.
    Type: Grant
    Filed: March 17, 1988
    Date of Patent: September 12, 1989
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4856188
    Abstract: Applicators for the electrophoretic and/or electroosmotic deposition of a medicament across the skin and into the blood stream. The applicator includes a plurality of drug reservoir electrodes, a battery, a plurality of folded members each having an electrically conductive coating on a flexible, non-conductive substrate in electrical contact with the battery and the drug reservoir electrodes, electrical current conditioning means, and a cover adhesively secured to the applicator.
    Type: Grant
    Filed: October 7, 1987
    Date of Patent: August 15, 1989
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4808152
    Abstract: This invention relates to a system and method for controlling the rate of electrokinetic delivery of a drug or drugs through the skin (42) or mucous membrane of a human or animal being by way of a drug reservoir (12) having a pair of electrodes (16,18) positioned in the reservoir (12) that are connected to first (22A) and second (22B) power sources. The first (22A) and second (22B) power sources can be optionally directed to the electrodes (16, 18) to add to or subtract from the second (22B) power source so as to cause variations in the drug reservoir (12) in accordance with the type of drug being administered. The system can include computer (62) directed controls (66) programmed for the particular drug. With such pre-programmed variations in the drug reservoir (12), control of the rate of drug delivery through the skin (42) can be regulated or pre-set by prescription.
    Type: Grant
    Filed: January 5, 1987
    Date of Patent: February 28, 1989
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4734090
    Abstract: A transdermal drug applicator for passing at least one drug for delivery to the systemic circulation system of a patient through the skin. The applicator includes a drug applicator containing a colloidal suspension having at least one drug for delivery to the body of a patient, the colloidal suspension comprising a fluid medium and generally large, as compared to the size of molecules, particles in the fluid medium. The particles and the medium are of different permittivities. The drug reservoir is capable of being placed in electrical contact with the skin of the patient. A voltage device imposes electrostatic field lines upon the fluid medium so as to create a non-uniform electrostatic field in the fluid medium when the drug reservoir is placed on the skin. The particles migrate in accordance with the principle of dielectrophoresis so as to pass through the skin into the systemic circulation system.
    Type: Grant
    Filed: July 18, 1986
    Date of Patent: March 29, 1988
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4731926
    Abstract: Applicators for the electrophoretic and/or electro-osmotic deposition of a medicament across the skin and into the blood stream. The applicator includes a plurality of drug reservoir electrodes, a battery, a plurality of folded members each having an electrically conductive coating on a flexible, non-conductive substrate in electrical contact with the batttery and the drug reservoir electrodes, electrical current conditioning means, a cover adhesively secured to the applicator, and a release liner covering and protecting the drug reservoirs until use. A method of manufacturing the applicator is set forth.
    Type: Grant
    Filed: December 10, 1985
    Date of Patent: March 22, 1988
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4713050
    Abstract: An indicator for the electrophoretic deposition of a medicament through or on a skin surface. The device includes layers forming a reservoir containing the drug, a battery layer superimposed on the reservoir, and a cover of electrically conductive material fully enclosing the layers and having a lip along its periphery to electro-conductively engage the skin surface and form an electrical circuit.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: December 15, 1987
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4708716
    Abstract: A transdermal drug applicator for application to a body for the migration of medicament through the skin into the blood stream of a patient embodies a plurality of reservoirs for containing the medicament. A battery which supplies a charge for the medicament in the applicator is disposed adjacent one side of the reservoirs with a side of the battery facing the reservoir for charging/driving the medicament. Also, a cover comprising an electrically conductive material partially encloses the battery and one side of the reservoir opposite that of the battery is exposed for contacting the skin. An electrical circuit is further provided for electrically connecting the battery to the cover, and the cover having a lip defining the periphery of the applicator for making contact with the skin when mounted on the skin leaving the battery and reservoir generally fully enclosed.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: November 24, 1987
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4640689
    Abstract: An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reservoir means, in at least one of said electrode elements of said applicator, containing said medicament; and a circuit, including a power source, for supplying electric power to said electrodes and such reservoir means. Suitable cover means partially enclosed at least said reservoir means, and adhesive means affixes the applicator to the skin, so as to complete an electrical circuit through the skin when the applicator is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: February 3, 1987
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4622031
    Abstract: An indicator for indicating the in vivo delivery of a drug by the electrophoretic deposition of a medicament through or on a skin surface. The device includes layers forming a reservoir containing the drug, a battery layer superimposed on the reservoir, and a cover of electrically conductive material fully enclosing the layers and having a lip along its periphery to electro-conductively engage the skin surface and form an electrical circuit. An indicator, such as an LCD or an electrochemically phototropic material (ECM) is in the circuit during which closing of the circuit, the current causes delivery of the drug and activates the LCD or ECM so as to indicate delivery to the user.
    Type: Grant
    Filed: October 12, 1984
    Date of Patent: November 11, 1986
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis
  • Patent number: 4557723
    Abstract: An applicator for the electrophoretic deposition of a medicament through or on a skin surface. The device consists of layers of a reservoir containing the drug, a battery layer superimposed on the reservoir, and a cover of electrically conductive material fully enclosing the layers and having a lip along its periphery to engage the skin surface. An electrically conductive adhesive bonds the lip of the cover to the skin.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: December 10, 1985
    Assignee: Drug Delivery Systems Inc.
    Inventor: Dan Sibalis