Patents Assigned to DSM Catalytica Pharmaceuticals, Inc.
  • Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
    Patent number: 6743921
    Abstract: The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: June 1, 2004
    Assignees: DSM Catalytica Pharmaceuticals, Inc., Pfizer, Inc.
    Inventors: Charles E. Tucker, Qiongzhong Jiang
  • Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl -piperidin-1-yl)-1-propanol compounds
    Publication number: 20030144521
    Abstract: The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.
    Type: Application
    Filed: January 24, 2002
    Publication date: July 31, 2003
    Applicant: DSM CATALYTICA PHARMACEUTICALS, INC.
    Inventors: Charles E. Tucker, Qiongzhong Jiang
  • Preparation of chiral 6,7-dihydroxy geranyloxy compounds
    Patent number: 6600062
    Abstract: The present invention provides a method for enantioselectively producing a nonracemic 6,7-dihydroxy geranyloxy compound from a geranyloxy compound. In particular, methods of the present invention involve enantioselectively epoxidizing the geranyloxy compound and hydrolyzing the epoxide moiety under conditions sufficient to produce the nonracemic 6,7-dihydroxy geranyloxy compound.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 29, 2003
    Assignees: DSM Catalytica Pharmaceuticals, Inc., Colorado State University Research Foundation
    Inventors: Robert Seemayer, Yian Shi
  • Preparation of chiral 6,7-dihydroxy geranyloxy compounds
    Publication number: 20020095061
    Abstract: The present invention provides a method for enantioselectively producing a nonracemic 6,7-dihydroxy geranyloxy compound from a geranyloxy compound. In particular, methods of the present invention involve enantioselectively epoxidizing the geranyloxy compound and hydrolyzing the epoxide moiety under conditions sufficient to produce the nonracemic 6,7-dihydroxy geranyloxy compound.
    Type: Application
    Filed: December 20, 2001
    Publication date: July 18, 2002
    Applicant: DSM CATALYTICA PHARMACEUTICALS, INC.
    Inventors: Robert Seemayer, Yian Shi