Abstract: The invention relates to a training device for an automatic injector. The device comprises a cylindrical outer sleeve in the rear portion of which a discharge mechanism is connected and in the front portion of which a holder intended for accommodating a punch member is incorporated so as to be locked against forward movement. The discharge mechanism comprises a plunger, a coil spring which acts on the plunger, a locking device and a safety member. The holder for the punch member comprises a sleeve-like rear portion which is open at each end. The punch member is accommodated in the holder such that its rear end at least substantially engages the front end of the plunger, and such that the front prod-shaped end portion which has dimensions such that it can pass through the central aperture in the nose portion of the holder outwards, is present within the holder prior to use of the device. The device further comprises auxiliary means for making the device ready for reuse.

Abstract: For the manufacture of lactulose, an alkaline aqueous solution of lactose and borax is prepared and heated at a temperature above 80.degree. C. The lactulose is separated from the resulting conversion products. Apart from the borax, no alkalizing material is added to the solution. The conversion is carried out at pH 8.3.In order to maintain the sodium ions in the production cycle, the borax may be manufactured in an aqueous solution of boric acid and already simultaneously with the lactose, while the sodium ions are transferred from the solution of the conversion products in the solution of the boric acid by electrodialysis.Alternatively the sodium ions may also be removed from the solution of the conversion products as readily as possible by means of a weakly acid ion exchanger and only thereafter by means of a more strongly acid ion exchanger.The weakly acid ion exchanger is regenerated with boric acid so that borax is formed again.

Abstract: The invention relates to a new group of 8,9-annelated-1,2,3,4-tetrahydro-.beta.-carbolines of the formula ##STR1## and the salts and prodrugs thereof. The meanings of R.sub.1, n, Z, R.sub.2, R.sub.3, and R.sub.4 are defined within the body of the specification.It has been found that the compounds have good fibrinolytic properties and can be used in particular as orally active fibrinolytics.

Abstract: Annelated indoleketones with an imidazolylalkyl substituent having the formula (2): ##STR1## wherein R.sub.1 is alkyl or alkoxy having 1-4 C-atoms, hydroxy, halogen, trifluoromethyl, a group R.sub.5 R.sub.6 N or R.sub.5 R.sub.6 -N-CO, wherein R.sub.5 and R.sub.6 are hydrogen or alkyl having 1-4 C-atoms or wherein R.sub.5 R.sub.6 N is a saturated 5-6 ring, and n has the value 0, 1 or 2;A is a group of formula 3, 4 or 5 ##STR2## wherein one of the groups R.sub.2, R.sub.3 and R.sub.4 is hydrogen, alkyl having 1-4 C-atoms, cycloalkyl having 3-6 C-atoms or alkenyl having 2-4 C-atoms and the two other groups, independently of each other, are hydrogen or alkyl having 1-4 C-atoms,p has the value 0-3, and q has the value 2-5. These compounds (and pharmaceutically acceptable acid addition salts thereof) have good antagonistic activity of "neuronal" 5-hydroxytryptamine(5-HT)receptors, and the lower toxicity.

Abstract: The invention relates to a water purification set comprising a container holding a filtering unit and a chemicals unit, said container comprising two compartments having such dimensions that the filtering unit can be accommodated in one compartment and the chemicals unit can be accommodated in the other compartment, and in which the compartment holding the filtering unit can be closed separately by means of a cover, the cover of the compartment holding the chemicals unit being proportioned so that the said latter cover, in closed condition of the compartment holding the filtering unit, can at least partly also cover the cover of the said latter compartment.

Abstract: The present invention is concerned with compounds of formula 1: ##STR1## wherein R.sub.1 is straight or branched alkyl having 1-4 C-atoms, halogen or cyano;n has the value 0-1;R.sub.2 is hydrogen, (1-6 C)alkyl, (3-6 C)alkenyl, (3-6 C)alkenyl, (3-6 C)cycloalkyl, (3-6 C)cycloalkyl-(1-4 C) alkyl, phenyl, phenyl-(1-3 C)alkyl, COOR.sub.6, COR.sub.6, CONR.sub.6 R.sub.7 or SO.sub.2 --R.sub.6, wherein R.sub.6 and R.sub.7 independently of each other are hydrogen, (1-6 C)alkyl, (3-6 C)cycloalkyl, phenyl or phenyl-(1-4 C)alkyl, wherein the benzene ring is optionally substituted with a methyl group or a halogen atom, with the proviso that R.sub.6 is not hydrogen when R.sub.2 is a group COOR.sub.6 or SO.sub.2 R.sub.6 ;R.sub.3 is hydrogen, straight or branched (1-6 C)alkyl or a phenyl-(1-3 C)alkyl group optionally substituted in the benzene ring; andA is a group of formula 2 or 3 ##STR2## wherein one of the groups R.sub.8, R.sub.9 and R.sub.

Abstract: The invention relates to a training device for an automatic injector, comprising a cylindrical outer sleeve, in the rear portion of which a discharge mechanism is connected and in the front portion of which a holder for a punch member is accommodated so as to be locked against forward movement. The discharge mechanism comprises a plunger, a coil spring which acts on the plunger, a locking device and a safety member. The holder for the punch member comprises a sleeve-like rear portion which is open at each end. The punch member is accommodated in the holder so that the front prod-shaped end portion, which has such dimensions that it can pass throuogh the central aperture in the nose portion of the holder outward, is present inside the holder prior to use of the device.

Abstract: The invention relates to a method for the photochemical conversion of tachysterol compounds into previtamin D compounds and of trans-vitamin D compounds into cis-vitamin D compounds under the influence of radiation, by exposing the tachysterol compound and trans-vitamin D compound, respectively, dissolved in a suitable solvent system, in the presence of a polymeric photosensitizer consisting of a polymer chain ("backbone") comprising covalently bound sensitizers suitable for the photochemical conversion, to light with a wavelength of preferably between approx. 300 and approx.

Abstract: The invention relates to a portable detection kit including a number of detection strips and at least one device for breaking reservoirs within the detection strips. The detection strips detect and identify chemical air contaminants and comprise a holder. The holder has a plurality of spaced carriers which are capable of absorbing the air contaminants and optionally comprise reagents which can be influenced by the air contaminants. The holder further has a plurality of color-producing agents opposite to the carriers. The agents, in contact with the absorbed air contaminants or with the reagents, can cause a color reaction in the presence of a liquid. The color-producing agents, which are dissolved in the quantities of liquid required for the color reaction, are held in closed reservoirs having easily breakable walls.

Abstract: The invention relates to a new method of preparing lactulose by basic isomerization of lactose. According to the invention the reaction mixture is treated with hydrogen peroxide or sodium chlorite to obtain lactulose of an acceptable color for a pharmaceutical product.Preferably 0.5-5 g of hydrogen peroxide are used per kg of lactose.1H.sub.2 O.

Abstract: A stabilized aqueous adjuvant suspension of dimethyl dioctadecyl ammonium bromide stabilized with at least 0.1 part by weight of a polymer of acrylic acid crosslinked with polyallyl sucrose per part by weight of dimethyl dioctadecyl ammonium bromide, plusa method of stabilizing vaccines adjuvanted with such dimethyl dioctadecyl ammonium bromide.

Abstract: The compound of the formula ##STR1## wherein R.sub.6 is H or Halo and R is alkoxy or alkyl thio, having, with (CH.sub.2)n a total of up to eight carbon atoms are described as having antidepressant as well as sedative activity.

Abstract: The invention relates to new thio compounds of the general formula ##STR1## wherein R is an alkyl group substituted or not substituted with halogen and having 1-12 carbon atoms, an alkenyl or alkynyl group having 2-4 carbon atoms, an alkadienyl group having 3 or 4 carbon atoms or a substituted or unsubstituted phenyl or phenyl(C.sub.1 -C.sub.4)alkyl group;R.sub.1 is a cyano group, a formyl group, an alkylcarbonyl or alkoxycarbonyl group substituted or unsubstituted with halogen and having 2-5 carbon atoms, a substituted or unsubstituted benzoyl group, or an alkylsulphonyl group having 1-4 carbon atoms;R.sub.2 is a hydrogen atom, a halogen atom, an amino group unsubstituted or substituted with one or two groups selected from C.sub.1 -C.sub.4 alkyl and C.sub.2 -C.sub.5 alkylcarbonyl, an amino group forming part of a heterocyclic ring which may comprise 1 or 2 additional heteroatoms selected from N, O and S, an alkyl or alkoxy group having 1-4 carbon atoms and optionally substituted with C.sub.2 -C.sub.

Abstract: The invention relates to new 1,7-annelated esters and amides of indolecarboxylic acids having general formula 2, ##STR1## wherein the symbols have the meanings given in the specification. The compounds and their salts are very strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors, and can be used for the treatment of symptoms which are caused by over-stimulation of these receptors.

Abstract: The invention relates to a group of new substituted 1,7-annelated 1H-indazole derivatives being strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors.

Abstract: The invention relates to a group of new 1,4-diazepine derivatives of the formula ##STR1## wherein A represents a group of the formulae 2-10 ##STR2## These compounds have a strong anti-ulcer activity after oral administration.

Abstract: The invention relates to a group of new substituted 1,7-annelated 1H-indazole derivatives being strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors.

Abstract: The invention relates to new anellated indole derivatives of general formula 2, ##STR1## wherein p1 R.sub.0 is alkyl or alkoxy having 1-4 C-atoms, phenylalkoxy having 1-3 C-atoms in the alkoxy group, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or a group R.sub.7 S(O).sub.p, wherein R.sub.7 is alkyl having 1-4 C-atoms and p has the value 0, 1 or 2, or R.sub.0 is a group R.sub.8 R.sub.9 N, R.sub.8 R.sub.9 N--CO--CH.sub.2 -- or R.sub.8 R.sub.9 --N--CO wherein R.sub.8 and R.sub.9 are hydrogen or alkyl having 1-4 C-atoms or R.sub.8 R.sub.9 N forms a saturated 5- or 6-membered ring and n has the value 0, 1 or 2, Z together with the carbon atom and nitrogen atom to which Z is bound and the intermediate carbon atom, forms a heterocyclic group consisting of 5-8 ring atoms, in which, in addition to the nitrogen atom already present, a --CO--group or a second hetero atom from the group N, O, S, S-O or SO.sub.

Abstract: The invention relates to a method of preparing a solid composition of lactulose in a simple way. According to the invention lactulose syrup is mixed with Fiberform.RTM., i.e. a fibre product based on the husks of corn grains having a fibre content of more than 80%. The mixture is spread, dried, crushed and optionally sieved.

Abstract: The invention relates to a herbicidally active compound of the general ##STR1## wherein R.sub.1, R.sub.2 R.sub.3 and R.sub.4 are equal or different and represent hydrogen atoms, alkyl groups having 1-6 carbon atoms, cycloalkyl groups having 3-6 carbon atoms or alkoxycarbonyl groups having 2-5 carbon atoms;R.sub.5 is a hydrogen atom, an alkyl group or haloalkyl group having 1-8 carbon atoms, a substituted or non-substituted phenyl group, a substituted or non-substituted heterocyclic group, or an alkenyl, alkynyl or alkoxycarbonyl group having 2-5 carbon atoms;and wherein two of the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 together may form a straight or branched alkylene group having 3-5 carbon atoms;Ar is a phenyl group, a phenyl (C.sub.1 -C.sub.4)alkyl group or a heteroaryl group;R.sub.