Patents Assigned to E. R. Squibb and Sons, Inc.
  • Patent number: 5714232
    Abstract: The invention is a wound dressing prepared from alginate fibers which have good structural integrity, whereby layers are firmly joined together, e.g. by stitching or calendering at a plurality of points to produce a composite fabric.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: February 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Charles Fenton, Allison Frances Keys, Peter Michael John Mahoney
  • Patent number: 5709674
    Abstract: An ostomy coupling includes a first coupling ring attached to a medical grade adhesive pad, a second coupling ring attached to an ostomy pouch, and an intervening ring. The intervening ring is slidable along the lower portion of the cylindrical wall of the first coupling ring. The intervening ring is also finger-engageable so as to facilitate the pushing together of the first and second coupling rings into a coupling arrangement while minimizing pressure on the stomal area.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: January 20, 1998
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: 5709673
    Abstract: The ostomy pouch has a coupling or securement member formed as a washer-shaped wafer of adhesive material, preferably a hydrocolloid. The pouch is secured directly onto the abdominal wall with the adhesive wafer aligned with the stoma. Flushability of the pouch is enhanced by forming the pouch with converging side walls within an optimum angular range and a predetermined pouch width and pouch height. The pouch also has a predetermined wall thickness and the wafer is of predetermined thickness. Thus when the pouch is deposited in a water-saver toilet, bottom end first in a carrier sleeve, the pouch can flow in streamlined fashion through the passages of a toilet and any sewer pipe or septic line connected to the toilet. If the flush capacity of the toilet and the flow rate of water through the toilet and sewer line are increased, the ostomy pouch can be deposited in the toilet without a carrier sleeve.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: January 20, 1998
    Assignee: E.R.Squibb & Sons, Inc.
    Inventor: Denis E. Keyes
  • Patent number: 5705645
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: January 6, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Patent number: 5693036
    Abstract: A method of injection moulding an undercut formation on a circular body in which the formation is moulded in a series of arcuate sections alternating with spaces. According to the method, the moulding core, which produces the formation, is extracted by firstly relatively rotating the body and the core so that the body is expanded radially and then ejecting the body off the core. The method is applicable to the manufacture of closure members and coupling elements.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: December 2, 1997
    Assignee: E. R. Squibb & Sons Inc.
    Inventor: Richard D. Kilgour
  • Patent number: 5691152
    Abstract: Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: November 25, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson
  • Patent number: 5691322
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.
    Type: Grant
    Filed: October 31, 1995
    Date of Patent: November 25, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Jeffrey Adam Robl
  • Patent number: 5690955
    Abstract: An alginate fibre is provided which includes one or more medicaments incorporated into the fibre core such that the one or more medicaments can be released in a sustained manner over time and, optionally, one or more medicaments attached to the surface of the fibre whereby the one or more medicaments attached to the surface of the fibre can be released rapidly therefrom.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: November 25, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Bryan Griffiths, Pter Michael John Mahoney
  • Patent number: 5686100
    Abstract: Methods and devices for preventing and/or treating an adverse reaction of the skin to the presence of a skin-sensitizing and/or skin-irritating agent by administering an effective amount of a loop diuretic alone or in combination with at least one mast cell degranulator or at least one glucocorticosteroid.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: November 11, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: John J. Wille, Agis Kydonieus
  • Patent number: 5686298
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: November 11, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, John K. Thottathil, Laszlo J. Szarka
  • Patent number: 5686433
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: November 11, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Jeffrey Adam Robl
  • Patent number: 5681579
    Abstract: In accordance with the present invention a novel wound dressing providing superior absorption and preventing leakage is disclosed. The present dressing comprises a hydrocolloid-containing polymeric support layer either continuous or non-continuous and an occlusive backing layer overlying the support. In a preferred embodiment the present dressing further includes an adhesive on a skin-contacting surface of the support and an absorbent region interposed between the support and the backing layer.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: October 28, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Frank Freeman
  • Patent number: 5681063
    Abstract: The connector assembly for double tubing includes a pair of interengageable coupling members that engage when latches on the respective coupling members are aligned in a predetermined nonlatching position. Locking of the coupling members together is accomplished by rotating one of the coupling members with respect to the other coupling member to interengage the respective latches of each coupling member. A latch section of one of the coupling members extends transversely of the coupling member body and a latch section of the other coupling member extends longitudinally of the coupling member body. A locking notch in one of the latch sections receives the other latch section to place the coupling members in a locked position when one of the coupling members is rotated to engage the latches. Further rotation of the coupling members unlatches the respective latch members to permit separation of the coupling members upon imposition of oppositely directed forces on each of the coupling members.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: October 28, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Gorm Bressner
  • Patent number: 5677344
    Abstract: A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.
    Type: Grant
    Filed: May 24, 1993
    Date of Patent: October 14, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Susan A. Greenfield, Denyse Levesque
  • Patent number: 5674458
    Abstract: A container for receiving and separating blood plasma into its ingredients that has two sealingly coupled sections (1 and 2). One container section (2) and the adjacent portion of the other container section are made of solid material, and the two container sections are screwed together. The container sections (1 and 2) comprise their respective chambers (29 and 30) for receiving their respective fluid ingredients, and these chambers are interconnected through a connecting channel (31) through the abutting portions, at which the container sections (1 and 2) are screwed together. A valve seat (21, 27) is shaped at each end of the connecting channel (31) for each valve member (22, 16) for a sealing closing of the chambers (29, 30) in the separated state of the container sections (1, 2).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Niels Erik Holm
  • Patent number: 5675060
    Abstract: A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire of a wildtype control animal. The TCR repertoire of the arthritic animal, albeit limited, is functionally viable. In a preferred embodiment, the invention relates to transgenic arthritic mice wherein arthritis results from (1) a transgenic allele which encodes and expresses TCR .alpha. and .beta. subunits that combine in T lymphocytes of the transgenic animal to form a TCR that recognizes an antigen comprising one or more epitopes of an oligopeptide derived from amino acids 41-61 of bovine pancreatic ribonuclease and/or (2) polypeptide arthritogenic self antigens derived from endogenous proteins.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: October 7, 1997
    Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Strasbourg 1, E.R. Squibb & Sons, Inc.
    Inventors: Christophe O. Benoist, Diane J. Mathis, Valerie Kouskoff
  • Patent number: 5670169
    Abstract: The present invention relates to a preserved, yet non-cytotoxic alginate based hydrating gel system for the purpose of treating wounds that need moisture. Sodium carboxymethylcellulose and an alginate polymer blend impart sufficient viscosity to an aqueous solution to provide moisture to the wound. The blend reduces the cytotoxicity of a combination of preservatives incorporated into the system. More specifically, the invention relates to a wound hydrating gel comprising a) a hydrocolloid mixture of carboxymethylcellulose and sodium/calcium alginate, and b) a preservative system. This invention further relates to methods of preparing and using the wound hydrating gel.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: September 23, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Marc D. Cornell, Nancy E. Kaiser, Rita A. Brenden
  • Patent number: 5665576
    Abstract: A method for the production of taxanes such as taxol. The method includes inducing formation of callus cells by contacting an explant tissue with a liquid medium without complete submergence of the tissue in the medium. The callus cells formed are employed in a liquid suspension cell culture to produce one or more taxanes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 9, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Paul M. Cino, Steven R. Schwarz, Dana L. Cazzulino
  • Patent number: 5662628
    Abstract: A coupling, which may be an ostomy coupling but could be any kind of tube or pipe coupling, includes a first coupling member 10 and a second coupling member 30 which are mutually interengageable and which surround an orifice 70. The coupling also includes a resilient split ring 50 which encircles the two coupling members and has a handle member 51 which can be manipulated to cause the split ring to be deformed. This causes the radially-inwardly extending tabs 52 on the ring to be shifted between respective first positions in which the split ring is undeformed and the tabs lock the two coupling members together and respective second positions in which the split ring is deformed in such a way as to shift the tabs radially outwardly to positions where they permit separation of the two coupling members.The split ring is desirably made of a relatively rigid but springy plastics material, for example an acetal resin.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: September 2, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Keith G. M. Hollands
  • Patent number: 5662629
    Abstract: It would be desirable to have improved designs of ostomy couplings which embody a springy or resilient split ring as a locking ring.In an ostomy coupling, first and second coupling members 20, 40 are held together by a springy flexible split locking ring 30. A plurality of tabs 31, 32, symmetrically arranged on each limb of the locking ring 30, can be withdrawn generally radially outwardly by movement of the locking ring to permit separation of the two coupling members. The ring 30 is generally circular in its unstressed condition.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: September 2, 1997
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Peter L. Steer, Keith G. M. Hollands, Graham Emery Steer, Ronald A. Plass, Howard Barratt