Patents Assigned to E. R. Squibb & Sons
  • Aminoalkylphosphonic acid esters of natural 4-methoxy-5-methyl-pyran-3-ol and derivatives thereof
    Patent number: 5248790
    Abstract: Antibiotic substances having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Process for preparing a cis oxabicyclo olefinic acid and ester from an oxabicyclo pyranol
    Patent number: 5245055
    Abstract: A compound having the structure ##STR1## is reacted with Ph.sub.3 P.dbd.CH(CH.sub.2).sub.3 Y wherein Y is --CO.sub.2 .sup..crclbar. M.sup..sym. or --C.tbd.N to form ##STR2## which is aminated and esterified to form ##STR3## which may be used to form [1S-[1.alpha.,2.alpha.(Z),3.alpha., 4.alpha.[[-7-[3-[[[[1-oxoheptyl) -amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]-hept-2-yl]-5-heptenoic acid.
    Type: Grant
    Filed: December 18, 1990
    Date of Patent: September 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Kronenthal, Robert Waltermire
  • Heterocyclic amido prostaglandin analogs
    Patent number: 5238951
    Abstract: Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula ##STR1## wherein: m is 1, 2, or 3;n is 0, 1, 2 or 3;R is CO.sub.2 R', CH.sub.2 OH, CONHSO.sub.2 R.sub.hu 3, CONHR.sup.4, or --CH.sub.2 -5-tetrazolyl;R' is hydrogen, alkyl, or alkali metal;X is O or NH;Y is --O--, a single bond or vinylene, except that Y cannot be --O-- when n is 0 and if Y is vinylene, then n=0; ##STR2## and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: August 24, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Philip M. Sher
  • Oxadiazinone substituted indole and benzimidazole derivatives
    Patent number: 5236916
    Abstract: Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Michael A. Poss
  • Process for the preparation of an antiviral agent
    Patent number: 5237095
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Process for the preparation of an antiviral agent
    Patent number: 5237096
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Method for treating Parkinson's disease employing quinine
    Patent number: 5236932
    Abstract: A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.
    Type: Grant
    Filed: November 18, 1991
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Susan A. Greenfield, Denyse Levesque
  • Substitute indole and benzimidazole derivatives
    Patent number: 5234923
    Abstract: Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: August 10, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael A. Poss, Karnail S. Atwal
  • Catheter holder
    Patent number: 5232453
    Abstract: A catheter holder has a pad of medical grade adhesive material having one surface for attachment to the skin of a wearer, and a pair of tapes secured to and extending from the other surface of the pad. A multiple use adhesive is placed on a surface of at least one tape which surface faces generally towards the other tape. With such an arrangement, the two tapes can be stuck together to enclose the catheter and at the same time the tape carrying the adhesive sticks to the adjacent wall of the catheter so preventing logitudinal movement of the catheter relative to the pad.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: August 3, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ronald A. Plass, Keith G. M. Hollands
  • Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside
    Patent number: 5233076
    Abstract: A novel process and intermediates are disclosed for the preparation of the optically active compound ##STR1## wherein R.sup.3 is a protecting group. This cyclobutanone compound is used to prepare a compound of the formula ##STR2## having anti-viral activity.
    Type: Grant
    Filed: April 29, 1991
    Date of Patent: August 3, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Saleem Ahmad
  • Intermediates for the preparation of an antiviral agent
    Patent number: 5233086
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylene-cyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: August 3, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Manufacture of bags
    Patent number: 5226564
    Abstract: A synthetic plastic bag for containing liquids, e.g., urine, has a plastic outlet tube. It is manufactured by a first step of seam welding the tube between two superposed bag walls. In a subsequent step, an encircling sleeve is slide over the tube to a position where it contains within it the portions of the bag walls on either side of the tube. Thirdly, this sleeve is compressed onto the tube by a crimping operation conducted with the crimping force applied in a direction radially of the tube but at substantially right angles to the plane in which the bag walls lie. Alternatively, after the tube is seam welded between the bag walls, the bag and tube combination is then placed between the blocks of a mold, each block having confronting recesses of a particular shape and molten plastics material is injected to fill these recesses. The injected material forms a collar which completely surrounds the tube.
    Type: Grant
    Filed: January 4, 1991
    Date of Patent: July 13, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter L. Steer, Graham E. Steer
  • Enteric coated pharmaceutical compositions
    Patent number: 5225202
    Abstract: An enteric coated pharmaceutical composition is provided which includes a medicament which is sensitive to a low pH environment of less than 3, such as pravastatin, which composition is preferably in the form of pellets which includes an enteric coating formed of neutralized hydroxypropylmethyl cellulose phthalate, plasticizer and anti-adherent. The so-coated pellets have good resistance to deterioration at pH less than 3 but have good drug release properties at greater than 3.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: July 6, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Garry R. Hodges, David L. McCann
  • Catheter retainer
    Patent number: 5224935
    Abstract: A catheter retainer is disclosed that includes an adhesive pad with projections. The catheter is secured to the pad by being tied to the projections.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: July 6, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Keith G. M. Hollands
  • Biphenyl oxadiazinone angiotensin II inhibitors
    Patent number: 5225408
    Abstract: Angiotension II inhibition is exhibited by ##STR1## wherein: R.sup.1 and R.sup.2 are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, thiophenalkyl, pyridylalkyl, or --R.sup.8 CO.sub.2 R.sup.9 ;R.sup.3 is a single bond, --S--, or --O--;R.sup.4 is hydrogen, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, or thiophenalkyl;R.sup.7 --(CH.sub.2).sub.n --CO.sub.2 R.sup.9, ##STR2## --NHSO.sub.2 CF.sub.3, --SO.sub.3 H, --C(CF.sub.3).sub.2 OH, ##STR3## --PO.sub.3 H, ##STR4## --CONHOR.sup.12, --CONHNHSO.sub.2 CF.sub.3, --(CH.sub.2).sub.n --5--tetrazolyl (optionally substituted with R.sup.9), and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: July 6, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Harold N. Weller, III
  • Treatment of congestive heart failure
    Patent number: 5225401
    Abstract: Congestive heart failure is treated by administration of a selective inhibitor of neutral endopeptidase and an angiotensin converting enzyme inhibitor. Captopril, fosinopril sodium, enalapril maleate and lisinopril are the preferred angiotensin converting enzyme inhibitors and the mercapto compounds of the formula ##STR1## are the preferred selective inhibitors of neutral endopeptidase.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: July 6, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Andrea A. Seymour
  • 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
    Patent number: 5223516
    Abstract: Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: June 29, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • 1,2-hydroxy phosphonates and derivatives thereof
    Patent number: 5217958
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: June 8, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Dinesh V. Patel
  • Process for the preparation of an antiviral agent
    Patent number: 5218142
    Abstract: Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: June 8, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Richard H. Mueller, Thomas P. Kissick, Janak Singh
  • Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker
    Patent number: 5215985
    Abstract: A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: June 1, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Kerry P. S. J. Murphy, Susan A. Greenfield