Patents Assigned to Ecole Normale Superieure de Lyon
  • Patent number: 10968253
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 6, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
  • Publication number: 20210017180
    Abstract: A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NORMALE SUPÉRIEURE DE LYON, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1), UNIVERSITÉ DE BRETAGNE OCCIDENTALE
    Inventors: Nadège HAMON, Maryline BEYLER, Raphaël TRIPIER, Olivier MAURY, Janah SHAYA
  • Publication number: 20200289049
    Abstract: The present invention relates to a non-implantable medical device (1, 1?) intended to cover wounds and skin lesions, comprising a biosensor (3E, 3E?), characterised in that said biosensor (3E, 3E?) comprises a piece made of absorbent, hydrophilic material fixing, on the surface and/or within the thickness thereof, a composition of agglomerated powders comprising particles of ethylene vinyl acetate (EVA) having a surface in part covered with at least one orthophosphoric acid salt and a visual indicator of microbiological growth. In particular, the medical device (1, 1?) may comprise several layers in order to enable the guiding of a liquid. The present invention relates to a method for preparing such a medical device (1, 1?).
    Type: Application
    Filed: November 29, 2018
    Publication date: September 17, 2020
    Applicants: Biomerieux, Elkem Silicones France SAS, F.D.S., Fibroline, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM), Ecole Normale Superieure De Lyon, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Christine Rozand, Aline Dardy, Fanny Berrat, Caroline Moine, Philippe Serre
  • Publication number: 20200246400
    Abstract: The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 6, 2020
    Applicants: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Universite Claude Bernard Lyon 1
    Inventors: François Leulier, Maria Elena Martino
  • Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Patent number: 10718697
    Abstract: A method for estimating a stiffness of a deformable part of a system including a four-photodiode detector for analyzing at least one characteristic of a sample. The method includes receiving the signals recorded by the four photodiodes, calculating the resultant signals from the recorded signals, calculating a cross-correlation of the resultant signals calculated for obtaining an intercorrelated signal, estimating the stiffness of the deformable part depending on the intercorrelated signal.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: July 21, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventor: Ludovic Bellon
  • Patent number: 10588986
    Abstract: The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 17, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ENS-ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD-LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), HOSPICE CIVILS DE LYON
    Inventors: Antoine Sicard, Olivier Thaunat
  • Publication number: 20200002367
    Abstract: The invention relates to novel glycosidase substrates of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R?9, V, X, Y and Z are as defined in claim 1, and a method for detecting the presence of a catalytically active glycosidase by means of one of said substrates.
    Type: Application
    Filed: December 19, 2017
    Publication date: January 2, 2020
    Applicants: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jens HASSERODT, Corentin GONDRAND, Maxime PROST, Gaël YVERT, Gérard TRIQUENEAUX
  • Publication number: 20190144885
    Abstract: The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
    Type: Application
    Filed: April 20, 2017
    Publication date: May 16, 2019
    Applicants: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche M edicale (INSERM)
    Inventors: Caroline Costa Fejoz, Els Verhoeyen, François-Loïc Cosset, Ruben Bender, Christian Buchholz, Qi Zhou
  • Patent number: 10266569
    Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 23, 2019
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de le Recherche Scientifique (CNRS), Université Claude Bernard—Lyon 1, Ecole Normale Superieure de Lyon (ENS de Lyon), Université Grenobles Alpes
    Inventors: Viktor Volchkov, Marc Jamin, Philip Lawrence, Filip Yabukarski
  • Patent number: 10179929
    Abstract: The invention provides probes with formula (I): in which: X1?NH, O, or S; X2?O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X2)—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: January 15, 2019
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jens Hasserodt, Maxime Prost
  • Publication number: 20180362550
    Abstract: The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I) : with X, Y and R1 as defined in claim 1, and to the salts thereof with an anion, the solvates and hydrates thereof; with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim 1, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim 1, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 20, 2018
    Applicants: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Oliver MAURY, Eric GIRARD, Sylvain ENGILBERGE, François RIOBE
  • Patent number: 10047106
    Abstract: The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a lanthanide ion Ln3+, wherein the chelating agent is substituted with at least two groups. The invention is most particularly applied to lanthanide complexes, the chelating agent of which is formed the with three ligands integrating a 2,6 pyridine-di(carboxylic acid) or is formed with a macrocycle having a 1,4,7 triazacyclononane structure.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: August 14, 2018
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier Maury, Chantal Andraud, Virginie Placide, Delphine Pitrat
  • Publication number: 20170320951
    Abstract: Methods for diagnosing and treating CD1d-restricted gamma/delta T cell lymphomas are disclosed. In particular, the present disclosure relates to a method for diagnosing a T cell lymphoma as a CD1d-restricted gamma/delta T cell lymphoma in a patient in need thereof including i) detecting the presence of CD1d restricted gamma/delta T lymphoma cells in a cell lymphoma sample obtained from the patient and ii) concluding that the T cell lymphoma is a CD1d-restricted gamma/delta T cell lymphoma when the presence of CD1d restricted gamma/delta T cells is detected in the sample. The present disclosure also relates to a method for treating a CD1d-restricted gamma/delta T cell lymphoma as diagnosed by the diagnostic method, including administering the patient with a therapeutically effective amount of a CD1d antagonist.
    Type: Application
    Filed: January 23, 2017
    Publication date: November 9, 2017
    Applicants: Institut National De La Santé Et De La Recherche Médicale (INSERM), Université Claude Bernard Lyon 1, Ecole Normale Supérieure De Lyon, Centre National De La Recherche Scientifique (CNRS)
    Inventors: Laurent Genestier, Emmanuel Bachy, Thierry Defrance
  • Patent number: 9783541
    Abstract: The subject matter of the present invention is compounds which have a 6-aminopurine backbone corresponding to formula (I): in which R1, R2, R3, X, Y and Z are as defined in any one of claims 1 to 5, and Ar is a biphenyl or a naphthyl which may be substituted with R3, for use in the treatment of cancer.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: October 10, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, HOSPICES CIVILS DE LYON, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE DE MONTPELLIER 1
    Inventors: Laurent Chaloin, Suzanne Peyrottes, Corinne Lionne, Zsuzsanna Marton, David Egron, Remi Guillon, Christian Perigaud, Charles Dumontet, Lars Petter Jordheim, Isabelle Krimm
  • Patent number: 9708238
    Abstract: Disclosed is a method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with a hydroperoxide in the presence of a catalytic effective amount of a crystalline MWW-type titanosilicate catalyst. Hydroperoxides may notably be tert-butyl hydroperoxide, tert-amyl hydroperoxide, cumene hydroperoxide, ethylbenzene hydroperoxide, cyclohexyl hydroperoxide, methylcyclohexyl hydroperoxide, tetralin hydroperoxide, isobutylbenzene hydroperoxide, and ethylnaphthalene hydroperoxide.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: July 18, 2017
    Assignees: Rhodia Operations, East China Normal University, Ecole Normale Superieure De Lyon
    Inventors: Floryan Decampo, Wenjuan Zhou, Peng Wu, Kai Xue, Yueming Liu, Mingyuan He
  • Publication number: 20170159100
    Abstract: The invention provides probes with formula (I): in which: X1?NH, O, or S; X2?O or S; SE is a labile group, which may be eliminated under the action of a stimulus that may in particular be the presence of an enzyme, a chemical compound, or a physicochemical characteristic of the medium in which the probe is located; A is an aromatic group that, following cleavage of the C(X2)—O bond in aqueous solution, leads to the liberation of a chromophore or a fluorophore, R represents a hydrogen atom or -(L)n-GP, in which n is equal to 0 or 1, L is a linker arm, and GP is a hydrosolubilizing group; as well as their physiologically acceptable salts, solvates, or hydrates. The invention also provides intermediates for the synthesis thereof and detection methods employing them.
    Type: Application
    Filed: June 24, 2015
    Publication date: June 8, 2017
    Applicants: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jens HASSERODT, Maxime PROST
  • Patent number: 9605296
    Abstract: The invention relates to novel peptidase substrates of formula (I): wherein R0, R1, R2, R3, R4, R5 and n are as defined in claim 1, and a method for detecting the presence of a catalytically active peptidase, by means of one of these substrates.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 28, 2017
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jens Hasserodt, Oliver Thorn-Seshold
  • Patent number: 9593362
    Abstract: The invention concerns novel glycosidase substrates of formula (I): where R0, R1, R2, R3, and R4 are such as defined in claim 1; and a method for detecting the presence of a catalytically active glycosidase using one of these substrates.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: March 14, 2017
    Assignees: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Jens Hasserodt
  • Publication number: 20170051149
    Abstract: The invention concerns a new class of tubulin polymerisation inhibitors and their applications in research and medicine, notably in chemotherapy. The invention proposes new azoaryl derivatives of formula (I): as defined in Claim 1, which may be fully reversibly interconverted between non-tubulin-binding trans and tubulin-binding as isomeric forms, either by irradiation or spontaneously.
    Type: Application
    Filed: April 29, 2014
    Publication date: February 23, 2017
    Applicants: ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Oliver THORN-SESHOLD, Malgorzata BOROWIAK, Dirk TRAUNER, Jens HASSERODT