Abstract: Provided is a method and apparatus for predicting a posttraumatic behavior problem that may predict a posttraumatic violent behavior problem of an individual, in detail, that may determine a biological phenotype of an individual experiencing a traumatic event within a predetermined period after the individual is exposed to the traumatic event, predict a violent symptom presentation probability of the individual based on the biological phenotype of the individual, and suggest an objective basis for preventive intervention in a development of posttraumatic stress disorder (PTSD) of the individual based on a prediction result.
Type:
Application
Filed:
January 29, 2018
Publication date:
May 2, 2019
Applicant:
Ewha University - Industry Collaboration Foundation
Inventors:
In Kyoon LYOO, Han Byul CHO, Ga Hae HONG
Abstract: Disclosed are a translationally controlled tumor protein derived-protein transduction domain (TCTP-PTD) having the ability to penetrate the cell membrane, and to the use thereof. The TCTP-PTD peptide is capable of improving the ability of a target substance to penetrate the cell membrane to thereby effectively deliver the target substance into a living body, including cells, tissue and blood. Thus, the TCTP-PTD peptide may be used for research purposes in vitro, and may be used for clinical purposes, including treatment of various diseases, delivery of contrast agents, etc., and may also be used for diagnostic purposes and in cosmetic applications.
Type:
Application
Filed:
April 6, 2017
Publication date:
April 18, 2019
Applicant:
Ewha University - Industry Collaboration Foundation
Inventors:
Kyung Lim Lee, Hea Duk Bae, Jee Hye Maeng
Abstract: Disclosed herein are a buffer cache apparatus, a journaling file system, and a journaling method capable of incorporating journaling features based on nonvolatile memory. The buffer cache apparatus provides a data buffering function between a central processing unit (CPU) and storage. The buffer cache apparatus includes a plurality of cache blocks and a journal management unit. The plurality of cache blocks are configured as volatile or nonvolatile memory devices. The journal management unit maintains states of freezing for write-protecting dirty up-to-date cache blocks among the plurality of cache blocks.
Type:
Grant
Filed:
April 15, 2013
Date of Patent:
December 11, 2018
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: The present invention relates to a method for promoting the generation and secretion of extracellular vesicles from cells by using extracorporeal shockwave. More precisely, the inventors confirmed that the generation and secretion of extracellular vesicles from vascular endothelial cells were promoted by extracorporeal shockwave and further confirmed that siRNA can be transferred into cells without any help of a carrier. The inventors continued to find out that angiogenesis could be inhibited by introducing siRNA to an animal tumor model and succeeded to measure the size and amount of extracellular vesicles secreted by extracorporeal shockwave. Therefore, the present invention can be used in various fields since it can safely promote the generation and secretion of extracellular vesicles from cells.
Type:
Grant
Filed:
January 20, 2017
Date of Patent:
November 13, 2018
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: The present invention relates to a portable analyzer for detecting bisphenol A, which comprises an aptamer specifically binding to bisphenol A, and a method for detecting bisphenol A using the same. The analyzer of the present invention can analyze a small amount of a sample collected from a contaminated environment in a field at a level similar to a laboratory environment, thereby having an effect of enabling a more immediate and accurate detection and quantification of bisphenol A.
Type:
Application
Filed:
February 20, 2018
Publication date:
November 8, 2018
Applicants:
Ewha University - Industry Collaboration Foundation, Korea University Research and Business Foundation
Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.
Type:
Application
Filed:
June 29, 2018
Publication date:
October 25, 2018
Applicant:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Inventors:
Sang Won KANG, Dong Hoon KANG, Doo Jae LEE
Abstract: The present invention relates to a microfluidic chip for screening anticancer drug resistant cells and a method for inducing or screening anticancer drug resistance using the same. The microfluidic chip of the present invention can induce a continuous concentration gradient between cell culture chambers and can implement the prompt induction and read-out within a week, unlike in existing read-out techniques, and thus, is expected to be able to take a target treatment through more fundament approach, in the treatment of cancer.
Type:
Application
Filed:
May 13, 2016
Publication date:
October 11, 2018
Applicants:
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: A method of manufacturing an electronic device is provided to realize efficient large-scale transferring. The method includes locating a transfer film over a plurality of functional layers separated from each other over a source substrate; attaching a support frame to the transfer film, the support frame having a plurality of holes spaced apart from each other; removing the source substrate from the transfer film, with the plurality of functional layers being in close contact with a bottom surface of the transfer film; locating the transfer film over a target substrate, with the plurality of functional layers being in close contact with the bottom surface of the transfer film; detaching the support frame from the transfer film; and removing the transfer film from the target substrate.
Type:
Application
Filed:
April 3, 2018
Publication date:
October 4, 2018
Applicant:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: A location determining method 200 for sensor apparatus placements in building includes: a step in which a first measuring device transmits a digitally modulated first test packet through a specific channel at a first location in a building (210); a step in which a second measuring device receives the first test packet and transmits a first echo back signal through the specific channel at a second location in the building (220); a step in which the first measuring device receives the first echo back signal transmitted from the second measuring device and measures a first channel quality of the specific channel based on the first echo back signal (230); a step in which the first measuring device transmits a digitally modulated second test packet through the specific channel (240); a step in which the second measuring device receives the second test packet and transmits a second echo back signal through the specific channel (250); and a step in which the first measuring device receives the second echo back signa
Type:
Grant
Filed:
December 15, 2014
Date of Patent:
October 2, 2018
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: In a method of analyzing a fault and/or error of an electronic system according to some example embodiments, a system call that accesses a hardware is replaced with a hooking system call including a code that executes the system call and a code that obtains monitoring information, the monitoring information including system call execution information and hardware performance information is obtained by executing the hooking system call when the hooking system call is called instead of the system call, and the monitoring information is recorded to analyze the fault/error of the electronic system based on the monitoring information.
Type:
Grant
Filed:
November 11, 2015
Date of Patent:
September 4, 2018
Assignees:
Samsung Electronics Co., Ltd., Ewha University-Industry Collaboration Foundation
Inventors:
Jang-Hyuk An, Byoung-Ju Choi, Ji-Hyun Park
Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.
Type:
Grant
Filed:
February 23, 2017
Date of Patent:
August 14, 2018
Assignee:
EWHA University Industry-Collaboration Foundation
Inventors:
Sang Won Kang, Dong Hoon Kang, Doo Jae Lee
Abstract: The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a pharmaceutically acceptable salt thereof; and the composition of the present invention is effective in reducing proteinuria, reducing cell formation between glomerular blood vessels and suppressing kidney fibrosis.
Type:
Grant
Filed:
August 2, 2013
Date of Patent:
August 14, 2018
Assignee:
Ewha University-Industry Collaboration Foundation
Inventors:
Yun Soo Bae, Hun Joo Ha, Kee In Lee, Kyung Hee Song
Abstract: Provided are transmembrane complexes that contain a protein transduction domain (PTD) from the N-terminus of IgE-dependent histamine-releasing factor (HRF) and a target substance that is to be delivered into a cell. Also provided are nucleic acid molecules encoding the transmembrane complex and methods of delivering the target substance into a cell interior by contacting the transmembrane complex with a cell. Also provided are transfection kits containing the PTD and the target substance.
Type:
Grant
Filed:
April 28, 2016
Date of Patent:
March 6, 2018
Assignee:
Ewha University-Industry Collaboration Foundation
Abstract: Provided are methods of treating a subject for of ovarian cancer, the method including using lysophosphatidylcholine (16:0) and homocysteic acid, which are low-mass ions present in biological samples, to diagnose whether treatment should be provided. The method enables ovarian cancer to be diagnosed in a cost-effective, rapid and accurate manner.
Type:
Grant
Filed:
August 21, 2014
Date of Patent:
February 6, 2018
Assignee:
Ewha University-Industry Collaboration Foundation
Inventors:
Seung Cheol Kim, Byong Chul Yoo, Kyung-Hee Kim, Yun Hwan Kim
Abstract: The present disclosure relates to a t-butylketone binaphthol derivative and a method of preparing the same, the t-butylketone binaphthol derivative being a high-efficiency chiral extracting agent which has a very high chiral selectivity enabling to extract an amino acid from an aqueous solution phase to an organic layer and to facilitate its hydrolysis, and enabling a continuous reuse of the organic layer.
Abstract: Disclosed is a transimpedance amplifier. The transimpedance amplifier includes an inverter configured to have a feedback resistor and amplify a signal provided to an input side, and a common gate amplifier configured to be connected to the inverter in cascade and amplify an output of the inverter, wherein the signal provided to the input side is fed forward to a gate of the common gate amplifier through a gate resistor.
Type:
Grant
Filed:
June 16, 2015
Date of Patent:
December 12, 2017
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Abstract: The present disclosure relates to an electrocatalyst for oxygen reduction including a silver/silver halide composite, a fuel cell including the electrocatalyst for oxygen reduction, and a method for preparing the electrocatalyst for oxygen reduction.
Type:
Grant
Filed:
April 11, 2013
Date of Patent:
October 24, 2017
Assignee:
Ewha University Industry Collaboration Foundation
Inventors:
Youngmi Lee, Chongmok Lee, Jun Ho Shim, Su-jin Kim
Abstract: A method for propagating network management data for energy-efficient internet of things network management and an energy-efficient internet of things node apparatus are disclosed herein. The method includes dividing a plurality of sub-nodes into at least two terminal sub-nodes and the remaining intermediate sub-nodes, and determining a transmission path so that the terminal sub-nodes and the intermediate sub-nodes satisfy an acyclic graph condition, dividing the plurality of pieces of data of network management information into at least two data groups, and transmitting one of the at least two data groups to one of the terminal sub-nodes respectively, transmitting the data of the received data group to adjacent intermediate sub-nodes, performing network coding on selected two pieces of data, transmitting the network-coded data to the at least two intermediate adjacent sub-nodes, and decoding the received network-coded data using previously held data.
Type:
Grant
Filed:
June 24, 2015
Date of Patent:
October 17, 2017
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Inventors:
Hyung gon Park, Jung min Kwon, Min hae Kwon, Soon young Kim, Min ji Lee, Ye seul Jo
Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
September 19, 2017
Assignee:
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION
Inventors:
Sang Won Kang, Dong Hoon Kang, Doo Jae Lee
Abstract: The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.
Type:
Application
Filed:
February 23, 2017
Publication date:
August 24, 2017
Applicant:
EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION