Abstract: A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.

Abstract: A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.

Abstract: Disclosed are various implementations for controlling an electric field within a focused beam of electromagnetic radiation. In one example, among others, a system includes a first birefringent element encodes a first phase shift on a vertical component of a polarization of an input beam. A first wave plate rotates a polarization of an output beam of the first birefringent element by an angle. A second birefringent element encodes a second phase shift to a vertical component of the output beam of the first wave plate. A second wave plate rotates a polarization of the output beam of the second birefringent element by another angle. By mechanically or electronically varying parameters of the system, the polarization in the focus of the beam can be continuously orientated in any desired direction.

Abstract: A dual channel spray gun, and method of use thereof, for fabricating nanostructures including a pharmaceutical/therapeutic agent having enhanced oral bioavailability. The nanostructures are a mixture of at least two (2) solutions/media substantially equally distributed as desired. The spray gun device uses gas pressure and/or two ultrasonicators to simultaneously prepare two solution systems for subsequent mixture and atomization. The gas pressure and frequencies of the ultrasonicators are adjustable for each channel of the spray gun. In operation, the spray gun is used to prepare microstructures that, for example, contain at least one active pharmaceutical agent in one solution system and excipients, such as coating or bioadhesives, in the other solution system. Any combination of solution systems is contemplated, such as both systems containing a pharmaceutical agent or both systems containing excipients.

Abstract: A pharmaceutical formulation and topical administration thereof for the treatment of psoriasis or any one or more symptoms associated therewith. The formulation contains a therapeutically effective amount pemetrexed alone as the active agent or can contain therapeutically effective amounts of pemetrexed in combination with siRNA-inhibiting TNF?. The formulation may further include a cationic surfactant, such as cetylpyridinum chloride, and urea for enhanced permeation through the stratum corneum of the patient or subject.

Abstract: An improved vegetated buffer water retention system. The current invention can be utilized for both smaller scaled (e.g., residential) purposes or larger scaled (e.g., agricultural, municipal, industrial) purposes. In certain embodiments, the system generally includes a perforated drainage pipe and an overflow controller (e.g., T-shaped member, arched overflow valve apparatus) in open communication with each other. These components allow the system to control the soil matrix water table. With additional valves, pumps, and water reservoirs, the system can control both the soil matrix water table and stored water reuse. The systems can be used not only to enhance plant root uptake and microbial utilization of nutrients and pollutants in water, but also to capture and reuse water inflows, thereby aiding in water conservation and preventing soil erosion.

Abstract: Various examples are described for an artificial intelligence valet system. In one example, among others, a distributed information sharing system can obtain route information associated with a geographic area and provide the route information to a user vehicle in response to a request. In another example, an autonomous user vehicle can receive a request to autonomously proceed to a user defined location; obtain route information; and determine a route to the user defined location using the route information. In another example, a collision avoidance system can determine if an object is in a path of travel of a vehicle based at least in part upon sensory data and maneuver the vehicle based at least in part upon an object determination. In another example, an accident reporting system can determine an occurrence of a violation of a vehicle; obtain recordings of the environment surrounding the vehicle; and report the violation.

Abstract: Novel compounds for the treatment of estrogen receptor-mediated disorders, including breast cancer, and methods of treatment using the novel compounds. The novel compounds, when administered in a safe and effective amount, present extended binding to estrogen receptors in breast tissue without activating the estrogen receptors. Estrogen is blocked from binding to the estrogen receptors for an extended period of time, effectively hindering growth of breast cancer cells.

Abstract: The fungus Metarhizum anisopliae and the fungus Beauveria bassiana have been found to be effective for control of small hive beetles in honey bee colonies. The control of small hive beetles in honey bee colonies is effected by applying to the beetle, the honey bee hive, the vicinity of the honey bee hive, or the surrounding soils, or the soil in the pan at the hive bottom board, a composition of a miticidally effective amount of Metarhizum anisopliae or Beauveria bassiana.

Abstract: Isolated disease-related genes from muscadine (Vitis rotundifolia) and Florida hybrid bunch grape (Vitis spp.) grapes, and complementary DNA associated therewith. The cDNA can be utilized in small RNA technologies to promote expression of disease tolerance-related genes to induce production of disease-tolerance related gene products for resisting disease occurrence in Florida hybrid bunch and V. vinifera. The genes include, but are not limited to, stilbene synthase, chalcone synthase, chitinase, PR 4, PR 10, ?-1, 3-glucanase, peroxidase, and a subunit of Oxygen-Evolving Enhancer Protein 1. These genes were found to enhance tolerance of Florida hybrid bunch and muscadine grape to a plurality of pathogenic diseases, including, for example, Pierce's disease and anthracnose.

Abstract: The compounds herein disclosed are N-substituted tetrahydroisoquinoline benzamide and benzene sulfonamide compounds that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-substituted tetrahydroisoquinoline compounds have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6- to 10-fold less than the IC50 of Tamoxifen.

Abstract: Dermal delivery is best suited for the various skin diseases or disorders. However, the stratum corneum limits the permeation of number of suitable pharmaceutical agents for dermal delivery. Certain embodiments of the present invention include surface modified multilayered nanostructures. The modification was completed by using fatty acids enabling delivery of a significant amount of one or more pharmaceutical agent(s) into deeper layers of the epidermis and dermis to treat skin diseases or disorders. Each active pharmaceutical agent can be encapsulated into the separate layers of the nanostructures.

Abstract: An indoloquinoline wherein the quarternary N-5 atom is a straight C(1-5) chain, a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring; the 10 position is N—R10, O, S, S?O, CH2, or C?O, where R10 is a branched C(1-5) chain, a heteroatom chain, a straight chain substituted terminally by a cycloalkyl or aromatic ring, a branched chain substituted terminally by a cycloalkyl or aromatic ring, a heteroatom chain substituted terminally by a cycloalkyl or aromatic ring. In one embodiment the quarternary N-5 atom is —CH3 and the 10 position is N—(CH2)5-Ph.

Abstract: Novel compounds for the treatment of estrogen receptor-mediated disorders, including breast cancer, and methods of treatment using the novel compounds. The novel compounds, when administered in a safe and effective amount, present extended binding to estrogen receptors in breast tissue without activating the estrogen receptors. Estrogen is blocked from binding to the estrogen receptors for an extended period of time, effectively hindering growth of breast cancer cells.

Abstract: Dermal delivery is best suited for the various skin diseases or disorders. However, the stratum corneum limits the permeation of number of suitable pharmaceutical agents for dermal delivery. Certain embodiments of the present invention include surface modified multilayered nanostructures. The modification was completed by using fatty acids enabling delivery of a significant amount of one or more pharmaceutical agent(s) into deeper layers of the epidermis and dermis to treat skin diseases or disorders. Each active pharmaceutical agent can be encapsulated into the separate layers of the nanostructures.

Abstract: The compounds herein disclosed are tetrahydroisoquinoline analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of tetrahydroisoquinoline have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.

Abstract: Various examples are described for an artificial intelligence valet system. In one example, among others, a distributed information sharing system can obtain route information associated with a geographic area and provide the route information to a user vehicle in response to a request. In another example, an autonomous user vehicle can receive a request to autonomously proceed to a user defined location; obtain route information; and determine a route to the user defined location using the route information. In another example, a collision avoidance system can determine if an object is in a path of travel of a vehicle based at least in part upon sensory data and maneuver the vehicle based at least in part upon an object determination. In another example, an accident reporting system can determine an occurrence of a violation of a vehicle; obtain recordings of the environment surrounding the vehicle; and report the violation.

Abstract: The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-aminopyrrolylmethyltetrahydropyridines have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.

Abstract: The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-aminopyrrolylmethyltetrahydropyridines have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.

Abstract: The compounds herein disclosed are tetrahydroisoquinoline analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of tetrahydroisoquinoline have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.