Patents Assigned to Florida Atlantic University
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Patent number: 12194058Abstract: A composition and method of cancer treatment including a) administering to a patient a first anti-parasitic agent; b) administering to the patient a second anti-parasitic agent; and c) administering to the patient a gut microbiome modulating agent; wherein the first anti-parasitic agent and the second anti-parasitic agent are administered concurrently for a predetermined first period of time; and wherein the gut microbiome modulating agent is administered for a predetermined second period of time.Type: GrantFiled: January 5, 2022Date of Patent: January 14, 2025Assignee: Florida Atlantic University Board of TrusteesInventors: Ceylan Isgor, Vijaya Iragavarapu
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Patent number: 12187813Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.Type: GrantFiled: February 10, 2023Date of Patent: January 7, 2025Assignees: Florida Atlantic University Board of Trustees, University of Florida Research FoundationInventors: Predrag Cudic, Jay McLaughlin
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Patent number: 12162575Abstract: Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion.Type: GrantFiled: April 9, 2021Date of Patent: December 10, 2024Assignee: Florida Atlantic University Board of TrusteesInventors: Bing Ouyang, Tsung-Chow Su, Yanjun Li, Jordan Thomas
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Patent number: 12158458Abstract: An exemplary portable automated device is developed for in vitro testing of blood vascular occlusion as a result of sickle cell disease. The portable automated device may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable automated device, analysis may be performed on sickle cell samples on a microfluidic platform that mimics the structure of human capillaries. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.Type: GrantFiled: May 6, 2021Date of Patent: December 3, 2024Assignee: Florida Atlantic University Board of TrusteesInventors: E Du, Yuhao Qiang, Darryl Dieujuste, Jia Liu
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Patent number: 12129311Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.Type: GrantFiled: February 10, 2023Date of Patent: October 29, 2024Assignees: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Predrag Cudic, Jay McLaughlin
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Patent number: 12083515Abstract: An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.Type: GrantFiled: March 7, 2023Date of Patent: September 10, 2024Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: E Du, Darryl Dieujuste, Jia Liu, Yuhao Qiang
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Patent number: 12083516Abstract: An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.Type: GrantFiled: March 7, 2023Date of Patent: September 10, 2024Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: E Du, Darryl Dieujuste, Jia Liu, Yuhao Qiang
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Patent number: 12061102Abstract: Systems and methods for operating a fluid supply system. The methods comprise: using a micro-turbine and an Energy Harvesting Circuit (“EHC”) to harvest energy from a fluid flowing through a pipeline; operating a switch to disconnect the EHC from the micro-turbine when an amount of energy harvested reaches a threshold value; detecting by a sensor device an amount of natural fluid flow through the pipeline while the EHC is disconnected from the micro-turbine; and operating the switch to reconnect the EHC to the micro-turbine after the amount of natural fluid flow has been detected.Type: GrantFiled: June 1, 2017Date of Patent: August 13, 2024Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: Jason O. Hallstrom, Jiannan Zhai, Chancey Kelley, Michael Brown, Andrew Van Zwieten, Don Salamon
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Patent number: 12048511Abstract: A video processing method improves the repeatability of point-of-care (POC) mean pixel intensity (MPI) analysis, for example by rejecting low-quality input data using image features. Using these features, the method selects high-quality frames and achieves an improvement in correlation and standard error for the MPI-absorbance relationship. In another example, a mobile device (e.g., smartphone) based image processing method produces an MPI output with smaller variances, lower limits of detection (LODs), and a higher dynamic range than existing methods. This method has improved performance in the presence of additive and multiplicative ambient light noise.Type: GrantFiled: October 21, 2019Date of Patent: July 30, 2024Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: Waseem Asghar, Benjamin Coleman, Chad Coarsey
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Patent number: 11719780Abstract: A practically implementable robust direction-of-arrival (DoA) estimation approach that is resistant to localization errors due to mobility, multipath reflections, impulsive noise, and multiple-access interference. As part of the disclosed invention the inventors consider infrastructure-less 3D localization of autonomous underwater vehicles (AUVs) with no GPS assistance and no availability of global clock synchronization. The proposed method can be extended to challenging communication environments and applied for the localization of assets/objects in space, underground, intrabody, underwater and other complex, challenging, congested and sometimes contested environments. Each AUV leverages known-location beacon signals to self-localize and can simultaneously report its sensor data and measurement location.Type: GrantFiled: August 28, 2020Date of Patent: August 8, 2023Assignee: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATIONInventors: Dimitris A. Pados, Konstantinos Tountas, Georgios Sklivanitis
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Patent number: 11722778Abstract: A method and apparatus provides for improved imaging of objects underwater. The method and apparatus are particularly useful in a degraded underwater visual environment. The method and apparatus are also useful in undersea operations in which enhanced visualization at close range is desirable. Exemplary operations include diver assist, ship hull inspections, underwater robotic operations (e.g. sample collection, mine neutralization), etc.Type: GrantFiled: August 8, 2019Date of Patent: August 8, 2023Assignee: Florida Atlantic University Board of TrusteesInventors: Bing Ouyang, Fraser Dalgleish, Frank Caimi, Anni Dalgleish
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Patent number: 11693005Abstract: Based on the discovery that MBLAC1 is a specific, high-affinity target for Ceftriaxone (Cef), MBLAC1 may be used for identifying treatments for addiction to substances of abuse. Methods for identifying therapeutic agents for treatment of addiction to a substance of abuse include using an assay to determine if a test agent is capable of binding to MBLAC1 or disrupting binding between MBLAC1 protein and Cef, and identifying such a test agent as a candidate therapeutic agent for treatment of addiction to a substance of abuse. MBLAC knock-out (KO) animals, methods of use thereof, and kits are used for identifying a therapeutic agent that reduces the actions of at least one substance of abuse. Methods also include using cellular extracts from tissue or cultured cells taken from wild-type (WT) MBLAC1 and MBLAC1 KO animals for screening for novel, Cef-like molecules in vitro, and using cells from a MBLAC1 KO animal to test for Cef-like actions of a test molecule.Type: GrantFiled: August 7, 2018Date of Patent: July 4, 2023Assignees: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES, VANDERBILT UNIVERSITYInventors: Randy D. Blakely, Maureen K. Hahn
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Patent number: 11618019Abstract: An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.Type: GrantFiled: September 27, 2019Date of Patent: April 4, 2023Assignee: Florida Atlantic University Board of TrusteesInventors: E Du, Darryl Dieujuste, Jia Liu, Yuhao Qiang
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Patent number: 11578100Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.Type: GrantFiled: January 25, 2019Date of Patent: February 14, 2023Assignees: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Predrag Cudic, Jay McLaughlin
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Patent number: 11370880Abstract: A novel polymer is provided by polymerization of xylitol and dodecanedioic acid. The polymer, poly(xylitol-dodecanedioic acid) or PXDDA, shows high elasticity. PXDDA significantly improves cell adhesion and promotes cell proliferation compared to an FDA-approved polymer, poly(lactic acid), and tissue-culture plates. PXDDA can be synthesized by a simple melt condensation polymerization without the use of any toxic catalysts.Type: GrantFiled: October 30, 2019Date of Patent: June 28, 2022Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventor: Yunqing Kang
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Patent number: 11221623Abstract: Systems and methods for controlling a vehicle. The methods comprise: receiving, by a computing device from at least one sensor, first sensor information specifying actions taken by a person while driving the vehicle or another vehicle; performing machine learning operations to learn first driving habits of the person based on at least one of the first sensor information; determining at least one autonomous driving rule for a particular driving style setting of a plurality of driving style setting options based on the machine-learned driving habits of the person; programming the particular driving style setting using the at least one autonomous driving rule; and causing the vehicle to enforce the at least one autonomous driving rule when the particular driving style setting is selected.Type: GrantFiled: October 19, 2018Date of Patent: January 11, 2022Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventor: Mehrdad Nojoumian
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Publication number: 20210323949Abstract: Novel compounds (small molecules) that potently and selectively inhibit MMP-13 (i.e., MMP-13 inhibitors) are used for treatment of multiple myeloma. The MMP-13 inhibitors described herein are highly selective for MMP-13 and when administered to an individual in need thereof, the compounds selectively kill multiple myeloma cells, reduce growth of multiple myeloma cells, inhibit multiple myeloma-induced osteoclastogenesis, and increase survival time in the individual.Type: ApplicationFiled: June 28, 2019Publication date: October 21, 2021Applicants: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES, H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Gregg B. Fields, Conor Lynch
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Patent number: 11152795Abstract: Systems and methods for providing federated power management in an electronic circuit. The methods comprise: performing first operations by a processing device to obtain information indicating a current level of charge for each of a plurality of capacitors which have been supplied energy from a power source; transforming, by the processing device, each capacitor's current level of charge into a number of service units for a respective electronic load device of a plurality of electronic load devices; determining, by the processing device, at least one of recharging priorities for the plurality of capacitors and discharging priorities for the plurality of capacitors at least based on the results of said transforming; and performing second operations by the processing device to cause the plurality of capacitors to be recharged in accordance with the recharging priorities or discharged in accordance with the discharging priorities.Type: GrantFiled: March 28, 2018Date of Patent: October 19, 2021Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: Jason O. Hallstrom, Jiannan Zhai, Chancey Kelley, Michael Brown, Alexander Roscoe
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Patent number: 11150658Abstract: Systems and methods for operating a HAUCS sensing platform. The methods comprise: autonomous travel by a UAAV to a first location in proximity to a body of water (“BoW”) in accordance with a mission plan; actuating a mechanical device to transition a sensor from a retracted position in which the sensor is adjacent to a UAAV to an extended position in which the sensor resides a given distance from a UAAV; collect, by HAUCS sensing platform and sensor, sensor data concerning a water condition of BoW at different depths; actuating the mechanical device to transition the sensor from the extended position to the retracted position after the sensor data has been collected; causing the sensor data to be processed using a machine learning-based analytical engine to determine whether a water distress condition exists/is predicted to occur; and modifying the mission plan when the water distress condition exists/is predicted to occur.Type: GrantFiled: March 6, 2020Date of Patent: October 19, 2021Assignee: Florida Atlantic University Board of TrusteesInventors: Bing Ouyang, Paul Wills, Jason Hallstrom, Tsung-Chow Su, Martin Riche, Peter Reiff, Yufei Tang
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Patent number: 11055437Abstract: Systems and methods for restricting a first computing device's output of information. The methods comprise: receiving, at the first computing device, information and at least one viewing restriction set for the information; collecting situational awareness information by the first computing device; using the situational awareness information to determine if the at least one viewing restriction is satisfied; and displaying the information on a screen of the first computing device if a determination is made that the at least one viewing restriction is satisfied or preventing the displaying of the information if a determination is made that the at least one viewing restriction is not satisfied.Type: GrantFiled: February 1, 2019Date of Patent: July 6, 2021Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEESInventors: Hari Kalva, Neha Kommireddy