Patents Assigned to Florida Atlantic University Board of Trustees
  • Patent number: 10759735
    Abstract: Neuroprotective compounds for reducing neurological damage due to cellular stress in an individual are of Formula 1: or an enantiomer, diastereomer, racemic mixture or a pharmaceutically acceptable salt thereof, wherein: Ar=aryl; Y=aryl substituent (ortho, meta, or para) selected from the group consisting of: alkyl, alkyloxy, alkylamino, R5R6N, and halo; X?O, N, or S; R?H, alkyl, aryl, OH, alkyloxy, aryloxy, NH2, alkylamino, R5R6N, or arylamino; R1 and R2=alkylcarbonyl, arylcarbonyl, alkyl, or H, individually; R3=arylCH?CH, alkylCH?CH, alkyl; R4?H, alkyl, or aryl; and R5 and R6=alkyl, individually. Methods of reducing neurological damage due to cellular stress in an individual include administering to the individual during or after the cellular stress a neuroprotective compound of Formula I in a therapeutically effective amount to restore synaptic function during or after the cellular stress.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: September 1, 2020
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Salvatore D. Lepore, Kenneth Dawson-Scully, Elijah J. St. Germain, Samantha L. Maki, Wesley L. Bollinger, Nadia K. Sial
  • Publication number: 20200181095
    Abstract: We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic structure of compound 5 in complex with MMP-13 with published structures of known MMP-13 inhibitor complexes followed by molecular design and synthesis of potent, but non-selective zinc-chelating MMP inhibitors (e.g., 10a and 10b). After demonstrating that the pharmacophores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active site, the Zn2+ chelating unit was replaced with non-chelating polar residues that bridged over the Zn2+ binding site and reach into a solvent accessible area.
    Type: Application
    Filed: June 6, 2018
    Publication date: June 11, 2020
    Applicants: Florida Atlantic University Board of Trustees, The Scripps Research Institute
    Inventors: Gregg B. FIELDS, William R. ROUSH, Jun Yong CHOI, Rita FUERST
  • Publication number: 20200062736
    Abstract: The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.
    Type: Application
    Filed: December 15, 2017
    Publication date: February 27, 2020
    Applicants: NOVA SOUTHEASTERN UNIVERSITY, AUBURN UNIVERSITY, FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: Dmitriy Minond, Gregg B. Fields, Marcello Giulianotti
  • Patent number: 10426143
    Abstract: Systems and methods for object enumeration in a culture tank. The methods comprise: obtaining an array of two dimensional images of an illuminated scene in a culture tank; correcting non-uniform background illumination in the two dimensional images; improving a color contrast between a background and object edges shown in the two dimensional images; performing a defocus analysis using the two dimensional images to generate a focus map image; generating a modified focus map image by eliminating isolated spots shown in the focus map image and merging relatively small spots with adjacent relatively large objects in the focus map image; classifying each object shown in the modified focus map image as an object of interest or an object of no interest; and counting the number of objects classified as objects of interest.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: October 1, 2019
    Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
    Inventors: Bing Ouyang, Paul S. Wills, Fraser Dalgleish, Anni Dalgleish
  • Patent number: 10398346
    Abstract: Systems and methods for guiding a sensor to locate a source of a propagating wave. The methods involve: presenting an electronic display comprising an image representing an object in which the sensor is placed and a visual indicator representing the sensor; receiving signals generated by electrodes while the sensor resides at a first location in the object; determining a First Recommended Direction of Travel (“FRDT”) for the sensor based on the received signals; using the FRDT to generate a mask that is to cover at least a portion of the image representing a portion of the object that is absent of the source; and modifying the electronic display to include the mask overlaid on top of the image and an arrow showing FRDT.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 3, 2019
    Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
    Inventors: Behnaz Ghoraani, Prasanth Ganesan
  • Patent number: 10398338
    Abstract: Systems and methods for guiding a sensor to a location of a propagating wave source. The methods comprise: receiving, by the computing device, a plurality of signals generated by a plurality of electrodes of the sensor while the sensor resides at the first location in the object; processing, by the computing device, the plurality of signals to determine coordinates of an estimated location of the propagating wave source relative to the first location at which the sensor resides; and providing a visual aid facilitating sensor movement by plotting a dot on a grid overlaid on top of an object image displayed by the computing device.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: September 3, 2019
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Behnaz Ghoraani, Prasanth Ganesan
  • Patent number: 10088571
    Abstract: Methods for characterizing scattering in a medium of a Light Detection And Ranging (LiDAR) system and systems therefrom are provided. A method includes obtaining off-axis power return characteristics with respect to a first wavelength of light and on-axis power return characteristics for at least the first wavelength of light. The method also includes estimating at least one beam attenuation coefficient (c) based on the off-axis power return characteristics and common volume parameter function for the LiDAR system and an extinction coefficient (?) for the medium based on the on-axis power return characteristics. The method further includes extracting a value for at least one diffuse attenuation coefficient (Kd) for the medium using a beam spread parameter for the LiDAR system (D) and a pre-defined relationship between ?, c, D, and Kd.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: October 2, 2018
    Assignee: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
    Inventors: Anni Vuorenkoski-Dalgleish, Fraser Dalgleish, Bing Ouyang
  • Patent number: 9181251
    Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: November 10, 2015
    Assignees: University of Central Florida Research Foundation, Inc., Florida Atlantic University Board of Trustees
    Inventors: Debopam Chakrabarti, Amy Wright
  • Publication number: 20140174373
    Abstract: The subject invention provides methods for producing cultured pearls in gastropods, such as the queen conch, Strombus gigas, and other gastropod species (e.g., families Strombidae, Haliotididae and Volutidae), with high success rates. The subject invention also provides cultured pearls produced by the methods as described herein.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicant: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
    Inventors: HECTOR ACOSTA-SALMON, MEGAN DAVIS
  • Patent number: 8691801
    Abstract: Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: April 8, 2014
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Esther A. Guzman, Jacob D. Johnson, Amy E. Wright
  • Patent number: 8232266
    Abstract: Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: July 31, 2012
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Esther A. Guzman, Jacob D. Johnson, Amy E. Wright
  • Publication number: 20110111465
    Abstract: Clonal strains of bacteria derived from Pseudopterogorgia elisabethae are capable of making pseudopterosins in in vitro cultures without requiring the presence of other bacteria, algae, or animal cells that are normally present in P. elisabethae.
    Type: Application
    Filed: December 29, 2010
    Publication date: May 12, 2011
    Applicants: UNIVERSITY OF PRINCE EDWARD ISLAND, FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sutaporn Bunyajetpong, Lory Z. Santiago-Vazquez, Russell Kerr
  • Patent number: 7626043
    Abstract: The subject invention provides novel biologically active compounds that have utility for use in inhibiting cellular proliferation. Pharmaceutical compositions comprising these compounds are also provided. In a specific embodiment, the compounds and compositions of the subject invention can be used in the treatment of cancer.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 1, 2009
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Amy E. Wright, John K. Reed, Jill Roberts, Ross E. Longley
  • Patent number: 7521474
    Abstract: The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: April 21, 2009
    Assignee: Florida Atlantic University Board of Trustees
    Inventors: Amy E. Wright, Shirley A. Pomponi, Peter J. McCarthy, Ying Chen, Ross E. Longley
  • Patent number: 7060686
    Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: June 13, 2006
    Assignees: The Regents of the University of California, Florida Atlantic University Board of Trustees
    Inventors: Robert S. Jacobs, Russell G. Kerr
  • Patent number: 6787571
    Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: September 7, 2004
    Assignees: The Regents of the University of California, Florida Atlantic University Board of trustees
    Inventors: Robert S. Jacobs, Russell G. Kerr