Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Abstract: A practically implementable robust direction-of-arrival (DoA) estimation approach that is resistant to localization errors due to mobility, multipath reflections, impulsive noise, and multiple-access interference. As part of the disclosed invention the inventors consider infrastructure-less 3D localization of autonomous underwater vehicles (AUVs) with no GPS assistance and no availability of global clock synchronization. The proposed method can be extended to challenging communication environments and applied for the localization of assets/objects in space, underground, intrabody, underwater and other complex, challenging, congested and sometimes contested environments. Each AUV leverages known-location beacon signals to self-localize and can simultaneously report its sensor data and measurement location.

Abstract: Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.

Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.

Abstract: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.

Abstract: The subject invention provides methods for producing cultured pearls in gastropods, such as the queen conch, Strombus gigas, and other gastropod species (e.g., families Strombidae, Haliotididae and Volutidae), with high success rates. The subject invention also provides cultured pearls produced by the methods as described herein.

Abstract: A method for mimicking the auditory system's response to rhythm of an input signal having a time varying structure comprising the steps of receiving a time varying input signal x(t) to a network of n nonlinear oscillators, each oscillator having a different natural frequency of oscillation and obeying a dynamical equation of the form r . = r ? ( ? + ? 1 ? ? z ? 2 + ? ? ? 2 ? ? z ? 4 1 - ? ? ? z ? 2 ) + c ? ? x ? ( t ) ? cos ? ? ? - r ? ? ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ? ? + 1 ? . = ? + ? 1 ? r 2 + ? ? ? 2 ? r 4 1 - ? ? ? r 2 - c ? ? x ? ( t ) ? sin ? ( ? ) ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ( ? ) + 1 ? ? ? . = - k ? ? x ? ( t ) ? sin ? ? ? ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ? ? + 1 wherein ? represents the response frequency, r is the amplitude of the oscillator and ? is the phase of the oscillator.

Abstract: A method for mimicking the auditory system's response to rhythm of an input signal having a time varying structure comprising the steps of receiving a time varying input signal x(t) to a network of n nonlinear oscillators, each oscillator having a different natural frequency of oscillation and obeying a dynamical equation of the form r . = r ? ( ? + ? 1 ? ? z ? 2 + ? ? ? 2 ? ? z ? 4 1 - ? ? ? z ? 2 ) + c ? ? x ? ( t ) ? cos ? ? ? - r ? ? ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ? ? + 1 ? . = ? + ? 1 ? r 2 + ? ? ? 2 ? r 4 1 - ? ? ? r 2 - c ? ? x ? ( t ) ? sin ? ( ? ) ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ( ? ) + 1 ? ? ? . = - k ? ? x ? ( t ) ? sin ? ? ? ? ? ? r 2 - 2 ? ? ? r ? ? cos ? ? ? + 1 wherein ? represents the response frequency, r is the amplitude of the oscillator and ? is the phase of the oscillator.

Abstract: The present invention is directed to systems and methods designed to ascertain the structure of acoustic signals. The approach involves an alternative transform of an acoustic input signal, utilizing a network of nonlinear oscillators in which each oscillator is tuned to a distinct frequency. Each oscillator receives input and interacts with the other oscillators in the network, yielding nonlinear resonances that are used to identify structure in an acoustic input signal. The output of the nonlinear frequency transform can be used as input to a system that will provide further analysis of the signal. According to one embodiment, the nonlinear responses are defined as a network of n expanded canonical oscillators zi, with an input, for each oscillator as a function of an external stimulus. In this way, the response of oscillators to inputs that are not close to its natural frequency are accounted for.