Patents Assigned to Fondation Mediterranee Infection
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Publication number: 20230310513Abstract: The invention relates to a method for feeding a flatworm and to a flatworm extract that is free of human-pathogenic microorganisms and is useful in the pharmaceutical, cosmetic and nutraceutical fields.Type: ApplicationFiled: August 30, 2021Publication date: October 5, 2023Applicants: FONDATION MEDITERRANEE INFECTION, AIX-MARSEILLE UNIVERSITEInventors: Didier RAOULT, Pierre Edouard FOURNIER, Eric GHIGO, Eric CHABRIÈRE
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Patent number: 11466261Abstract: Disclosed are mutated phosphotriesterase enzymes with improved stability and activity, as well as their use in particular for degrading organophosphorus compounds.Type: GrantFiled: July 17, 2018Date of Patent: October 11, 2022Assignees: LA FONDATION MEDITERRANEE INFECTION, I.N.S.E.R.M. (INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE), GENE AND GREEN TK, ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, AIX-MARSEILLE UNIVERSITE, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Eric Chabriere, David Daude, Mikael Elias
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Patent number: 11091735Abstract: The present invention relates to a polyvalent culture medium for anaerobic bacteria under aerobic conditions in blood culture bottles. The present invention provides a polyvalent culture medium for culture in aerobic atmosphere of anaerobic bacteria or aerobic bacteria comprising a basal culture medium for bacteria characterized in that it further comprises a mixture of the following antioxidant compounds: sodium hydrosulphide (Na2S), L-cysteine, ascorbic acid, glutathione, catalase, ubiquinol and lipoic acid.Type: GrantFiled: August 1, 2018Date of Patent: August 17, 2021Assignees: FONDATION MEDITERRANEE INFECTION FACULTÉ DE MÉDECINE, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier Raoult, Saber Khelaifia, Marion Bonnet
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Publication number: 20210161973Abstract: The present invention relates to an aqueous extract useful notably for the regeneration of human or animal cells, notably mammalian cells, comprising an aqueous extract free of any insoluble solid debris of ground planarian organisms having a regeneration capacity, containing at least the intracellular components of the cells of said organisms of a cell lysate of said cells of said organisms.Type: ApplicationFiled: May 30, 2018Publication date: June 3, 2021Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Eric GHIGO, Eric CHABRIERE, Michel DRANCOURT, Vincent BONNIOL
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Publication number: 20210139943Abstract: The present invention relates to a specific culture medium for the culture and selective isolation of an Enterococcus hirae bacterium consisting of nutrients other than sugars from a basic culture medium for the culture of enterococci without aesculin, comprising inhibitors of Gram-negative and Gram-positive bacteria other than enterococci and preferably at least one antifungal compound characterized in that it comprises: as inhibitor of Gram-positive bacteria other than enterococci, sodium chloride at a concentration of at least 20 g/L and not more than 60 g/L, and as the only sugar, mannitol, and as the only dye, an indicator dye that changes colour at a pH lower than the pH of said specific culture medium corresponding to the acidification of said specific is culture medium resulting from the consumption of mannitol.Type: ApplicationFiled: May 30, 2018Publication date: May 13, 2021Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier RAOULT, Saber KHELAIFIA, Marion BONNET
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Publication number: 20200407779Abstract: The present invention relates to an in vitro diagnostic method with regard to the presence of bacterial vaginosis, characterized in that the presence of bacterial vaginosis is determined if the archaea Methanobrevibacter smithii is present in a patient vaginal secretion sample by detecting therein the presence of at least one nucleic acid sequence specific to said methanogenic archaea Methanobrevibacter smithii.Type: ApplicationFiled: September 14, 2018Publication date: December 31, 2020Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLEInventors: Didier RAOULT, Michel DRANCOURT, Florence FENOLLAR, Ghiles GRINE
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Patent number: 10837044Abstract: The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype.Type: GrantFiled: October 5, 2015Date of Patent: November 17, 2020Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Jean-Marc Rolain, Didier Raoult, Stéphanie Le Page, Sylvain Buffet
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Publication number: 20200157490Abstract: The present invention relates to a polyvalent culture medium for anaerobic bacteria under aerobic conditions in blood culture bottles. The present invention provides a polyvalent culture medium for culture in aerobic atmosphere of anaerobic bacteria or aerobic bacteria comprising a basal culture medium for bacteria characterized in that it further comprises a mixture of the following antioxidant compounds: sodium hydrosulphide (Na2S), L-cysteine, ascorbic acid, glutathione, catalase, ubiquinol and lipoic acid.Type: ApplicationFiled: August 1, 2018Publication date: May 21, 2020Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier RAOULT, Saber KHELAIFIA, Marion BONNET
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Patent number: 10626421Abstract: The present invention relates to a method for cultivating in vitro in an acellular culture medium, bacteria for which the growth is sensitive to oxygen content, said bacterium being selected from anaerobic bacteria and intracellular micro-aerophilic bacteria, characterized in that uric acid is added into said acellular culture medium, and said bacterium is cultivated in said culture medium in the presence of oxygen.Type: GrantFiled: April 21, 2015Date of Patent: April 21, 2020Assignees: FONDATION MEDITERRANEE INFECTION FACULTÉ DE MÉDECINE, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier Raoult, Saber Khelaifia, Michel Drancourt
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Patent number: 10011852Abstract: The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).Type: GrantFiled: April 20, 2015Date of Patent: July 3, 2018Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier Raoult, Saber Khelaifia, Michel Drancourt
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Publication number: 20170298408Abstract: The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype.Type: ApplicationFiled: October 5, 2015Publication date: October 19, 2017Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),Inventors: Jean-Marc ROLAIN, Didier RAOULT, Stéphanie LE PAGE, Sylvain BUFFET
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Patent number: 9700051Abstract: The present invention relates to the use of a compound chosen from squalamine and a squalamine-analog aminosteroid compound as agent for disinfecting an inert material object, in particular for the pre-disinfection of medical, dental, diagnostic or surgical equipment. The present invention also provides an aqueous or water-soluble disinfecting composition beneficial for a use according to the invention, characterized in that as disinfecting active compound it comprises a said antibacterial and antifungal compound selected from squalamine and a said squalamine-analog aminosteroid compound and suitable excipients for a water-soluble or aqueous formulation.Type: GrantFiled: January 4, 2013Date of Patent: July 11, 2017Assignees: ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, UNIVERSITE D'AIX MARSEILLE, FONDATION MEDITERRANEE INFECTIONInventors: Jean-Michel Brunel, Didier Raoult, Jean-Marc Rolain
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Publication number: 20170191084Abstract: The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).Type: ApplicationFiled: April 20, 2015Publication date: July 6, 2017Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier RAOULT, Saber KHELAIFIA, Michel DRANCOURT
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Publication number: 20170183620Abstract: The present invention relates to a method for cultivating in vitro in an acellular culture medium, bacteria for which the growth is sensitive to oxygen content, said bacterium being selected from anaerobic bacteria and intracellular micro-aerophilic bacteria, characterized in that uric acid is added into said acellular culture medium, and said bacterium is cultivated in said culture medium in the presence of oxygen.Type: ApplicationFiled: April 21, 2015Publication date: June 29, 2017Applicants: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Didier RAOULT, Saber KHELAIFIA, Michel DRANCOURT
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Publication number: 20150157701Abstract: The present invention concerns the use of a strain of a mycobacterium of the Mycobacterium tuberculosis complex in which a mspA gene capable of expressing a porin A of Mycobacterium smegmatis has been inserted, to produce a vaccine for the prevention of infection with a bacterium of the Mycobacterium tuberculosis complex in a host having eukaryote cells, preferably macrophages, the said strain of mycobacteria thus transformed having reduced growth in the said eukaryote cells.Type: ApplicationFiled: May 16, 2013Publication date: June 11, 2015Applicant: Fondation Mediterranee InfectionInventors: Michel Drancourt, Otmane Lamrabet, Didier Raoult