Patents Assigned to Forsyth Dental Infirmary for Children
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Patent number: 11903998Abstract: Provided herein are methods for preventing or treating cancer in a subject comprising overexpressing at least one Receptor for a lipid agonist, such as G-protein receptors for Resolvin. Such methods may be combined with administering Resolvins, or lipoxins and their analogs, of said Receptors to enhance the pro-resolution effects of the Resolvins, or lipoxins and their analogs, in the local, inflammatory environment where cancer cells are already present.Type: GrantFiled: May 25, 2017Date of Patent: February 20, 2024Assignee: Forsyth Dental Infirmary for ChildrenInventors: Alpdogan Kantarci, Shevali Kansal, Hatice Hasturk, Thomas E. Van Dyke
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Patent number: 11896571Abstract: The invention provides methods for increasing oral osteogenesis using LXA4 and its analogs. Methods are also provided for treating or preventing oral disorders that would benefit from increased oral osteogenesis using LXA4 and its analogs.Type: GrantFiled: October 7, 2019Date of Patent: February 13, 2024Assignee: Forsyth Dental Infirmary for ChildrenInventors: Thomas E. Van Dyke, Hatice Hasturk, Alpdogan Kantarci
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Patent number: 11872255Abstract: Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries.Type: GrantFiled: January 13, 2022Date of Patent: January 16, 2024Assignee: Forsyth Dental Infirmary for ChildrenInventors: Pooja Balani, Felicitas Bidlack, Xuesong He, Megan Pugach-Gordon, Wenyuan Shi, Jacqueline Starr, Daniel Ferrer
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Patent number: 11246895Abstract: Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries.Type: GrantFiled: December 11, 2020Date of Patent: February 15, 2022Assignee: Forsyth Dental Infirmary for ChildrenInventors: Pooja Balani, Felicitas Bidlack, Xuesong He, Megan Pugach-Gordon, Wenyuan Shi, Jacqueline Starr, Daniel Ferrer
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Patent number: 10434080Abstract: The invention provides methods for increasing oral osteogenesis using LXA4 and its analogs. Methods are also provided for treating or preventing oral disorders that would benefit from increased oral osteogenesis using LXA4 and its analogs.Type: GrantFiled: March 15, 2013Date of Patent: October 8, 2019Assignee: Forsyth Dental Infirmary for ChildrenInventors: Thomas E. Van Dyke, Hatice Hasturk, Alpdogan Kantarci
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Patent number: 10080789Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.Type: GrantFiled: May 5, 2016Date of Patent: September 25, 2018Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for ChildrenInventors: Roger Warren Sands, Eduardo Alexandre Barros E Silva, Toshihisa Kawai, David J. Mooney
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Patent number: 9968577Abstract: The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolving are also provided that can be used to performed the inventive methods.Type: GrantFiled: December 19, 2013Date of Patent: May 15, 2018Assignee: Forsyth Dental Infirmary for ChildrenInventor: Thomas E. Van Dyke
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Patent number: 9925257Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.Type: GrantFiled: January 23, 2015Date of Patent: March 27, 2018Assignee: Forsyth Dental Infirmary for ChildrenInventors: Antonio Campos-Neto, Mark Cayabyab, Margaret Duncan
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Patent number: 9884108Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.Type: GrantFiled: June 3, 2016Date of Patent: February 6, 2018Assignee: Forsyth Dental Infirmary for ChildrenInventors: Antonio Campos-Neto, Mark Cayabyab, Margaret Duncan
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Patent number: 9381235Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.Type: GrantFiled: February 20, 2014Date of Patent: July 5, 2016Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for ChildrenInventors: Roger Warren Sands, Eduardo Alexandre Barros e Silva, Toshihisa Kawai, David J. Mooney
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Patent number: 9376686Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.Type: GrantFiled: September 21, 2012Date of Patent: June 28, 2016Assignee: Forsyth Dental Infirmary for ChildrenInventors: Antonio Campos-Neto, Mark Cayabyab, Margaret Duncan
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Publication number: 20140234423Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.Type: ApplicationFiled: February 20, 2014Publication date: August 21, 2014Applicants: FORSYTH DENTAL INFIRMARY FOR CHILDREN, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Roger Warren Sands, Eduardo Alexandre Barros e Silva, Toshihisa Kawai, David J. Mooney
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Patent number: 8802105Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.Type: GrantFiled: March 12, 2013Date of Patent: August 12, 2014Assignee: Forsyth Dental Infirmary for ChildrenInventors: Toshihisa Kawai, Philip P. Stashenko, Yoshitaka Hosokawa, Kazuhisa Ohara
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Patent number: 8728456Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.Type: GrantFiled: August 2, 2010Date of Patent: May 20, 2014Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for ChildrenInventors: Roger Warren Sands, Eduardo Alexandra Barros e Silva, Toshihisa Kawai, David J. Mooney
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Publication number: 20130095131Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.Type: ApplicationFiled: September 21, 2012Publication date: April 18, 2013Applicant: Forsyth Dental Infirmary for ChildrenInventors: Antonio Campos-Neto, Mark Cayabyab, Margaret Duncan
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Patent number: 8399220Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.Type: GrantFiled: April 16, 2010Date of Patent: March 19, 2013Assignee: Forsyth Dental Infirmary for ChildrenInventors: Toshihisa Kawai, Philip P. Stashenko, Yoshiaka Hosokawa, Kazuhisa Ohara
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Patent number: 8158123Abstract: The present invention features methods of treating a bone resorption disease or a bone generating disease, methods for prognosing and/or diagnosing a bone resorption disease or a bone generating disease, methods for identifying a compound that modulates bone resorption disease development or bone generating disease development, methods for determining the efficacy of a bone resorption disease therapy or a bone generating disease therapy, and oligonucleotide microarrays containing probes for genes involved in osteoclast development.Type: GrantFiled: December 11, 2003Date of Patent: April 17, 2012Assignee: Forsyth Dental Infirmary for ChildrenInventors: Philip Stashenko, Yoshimura Okamatsu, Hajime Sasaki, Richard Battaglino, Ulrike Späte
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Patent number: 8021148Abstract: The present invention relates to methods, systems, kits and devices that emit light to the oral cavity. The device includes a light source; a power source in electrical communication with the light source; and a bite actuated switch in electrical communication with the power source and the light source. The device is a size or shape that fits within an oral cavity of an individual. Since the device along with the light and power source are self contained, the user have their hands-free and can perform other activities while using the device. The device, methods, systems, and kits, further include the use of an agent (e.g., antibacterial agents, tooth whitening agents, cleaning agents) that assists or enhances the efficacy of the light therapy.Type: GrantFiled: May 3, 2007Date of Patent: September 20, 2011Assignee: Forsyth Dental Infirmary for ChildrenInventors: J Max Goodson, Nikos Soukos
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Patent number: 7968694Abstract: The present invention relates to isolated Tuberculosis (TB) antigens that are useful in therapeutic and vaccine compositions for stimulating a TB specific immunological response. The identified antigens are also useful in diagnostic assays to determine the presence of active TB in an individual. Accordingly, the present invention includes polypeptide molecules, nucleic acid molecules, vaccine compositions, diagnostic assays, and methods of diagnosis and monitoring treatment related to these TB antigens.Type: GrantFiled: June 29, 2006Date of Patent: June 28, 2011Assignee: Forsyth Dental Infirmary for ChildrenInventors: Antonio Campos-Neto, Suely S. Kashino
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Patent number: 7946849Abstract: Endodontic fibers including a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments, and method of using such endodontic fibers are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to intracanal treatment sites.Type: GrantFiled: December 17, 2007Date of Patent: May 24, 2011Assignee: Forsyth Dental Infirmary for ChildrenInventors: Mario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson