Abstract: Compositions and method are therefore disclosed for treating ARDS. In particular, disclosed a composition that contains one, two, or more cytidine diphosphate (CDP)-conjugated precursors selected from the group consisting of CDP-choline, CDP-ethanolamine, and CDP-diacylglycerol (CDP-DAG) in a pharmaceutically acceptable carrier for use in treating ARDS.

Abstract: Provided are compositions for inhibiting cellular proliferation comprising one or more CRL4CDT2 ubiquitin ligase inhibitors. Also provided are uses of the disclosed compositions to prepare medicaments, for treating and/or preventing diseases, disorders, and conditions, particularly for treating cancer, inducing apoptosis and/or rereplication in cells, inhibiting undesirable neddylation, overcoming vemurafenib-resistance in cells, treating melanoma, breast cancer, head and neck squamous carcinoma cell (HNSCC) cancer, a solid tumor, hepatocellular carcinoma, colorectal cancer, a non-small-cell lung cancer, serous ovarian cancer, papillary thyroid carcinoma, or ameloblastoma, and pharmaceutical compositions comprising the same.

Abstract: Systems and methods for providing digital reality experiences and decentralized transactions of real estate projects, comprising a server with a memory storing data models and data of virtual replicas of real estate properties stored in a project database and instructions for processing the virtual replicas, and a processor configured to process the data to provide digital reality experiences for users; and user devices connected to the server via a network, configured to detect and track virtual objects of the real estate projects and to output media content to users, enabling digital reality experiences. The server and the user devices are further configured to connect to a distributed ledger platform enabling decentralized record of user interactions comprising transactions with the real estate property.

Abstract: A thermal disinfection system, and related of method of use and manufacture, is implemented with a liquid-carrying conduit associated with a given plumbing system applicable with a given environment. The thermal disinfection system may include a heating device configured for thermal contact with at least a portion of the liquid-carrying conduit, thereby defining a thermal contact region of the liquid-carrying conduit. Additionally, a thermal insulating layer may disposed on the heating device. The heating device may be configured to heat (or heat and dry) a lumen defined by the liquid-carrying conduit along the thermal contact region (in whole or in part) to a specified temperature to prevent (e.g., suppress) or inhibit (e.g., reduce) microbial activity from advancing through the lumen defined by the liquid-carrying conduit.

Abstract: A semiconductor package includes: a substrate; a semiconductor chip disposed on a first surface of the substrate; solder bumps disposed between a first surface of the semiconductor chip and the substrate; and a redistribution layer provided on a second surface, opposite to the first surface, of the semiconductor chip. The substrate includes substrate patterns, and the substrate patterns cover a second surface of the substrate. The substrate patterns cover 60% to 100% of a total area of the second surface of the substrate.

Abstract: A system and method for enabling software engine virtualization and dynamic resource and task distribution across edge and cloud, comprising at least one cloud server comprising memory and at least one processor, the at least one cloud server hosting at least one cloud engine configured to store and process application data from one or more applications; one or more client devices connected to the cloud server via a network, the one or more client devices hosting at least one local engine configured to store and process application data from the one or more applications and to provide output to users; and a virtual engine hosted across edge and cloud configured to virtualize, via a virtualization logic component, one or more system network components, applications, and engine components, creating a virtual layer connected to the one or more client devices and cloud server via the network.

Abstract: A system for developing and deploying virtual replicas of real-world elements into a persistent virtual world system. The development of the virtual replicas is performed in a virtual environment that enables development and configuration of the virtual replicas that mirror the behavior and appearance of the corresponding real elements. The virtual replicas are enriched through data captured by sensing mechanisms that synchronize in real-time the virtual replicas with the real-world elements. The virtual replicas are shared in a virtual world-based quality assurance system where they can be either approved or rejected for subsequent adjustments, when necessary. After approval and deployment, the replicas are shared in a deployed persistent virtual world system that is viewable to end users for management and interaction of the virtual replicas. Methods thereof are also disclosed.

Abstract: A composition for promoting mitochondrial biogenesis includes an effective amount of an azelaic acid or a pharmaceutically acceptable salt thereof as an active ingredient. Azelaic acid, which is a compound mainly contained in cereals and natural products has the advantage of no or little side effects, and induces mitochondrial autophagy and mitochondrial DNA synthesis in cells, thereby having activity of increasing mitochondrial density. Therefore, azelaic acid can be used for the treatment of mitochondrial dysfunction-associated disease caused by the failure of homeostasis control of the mitochondria, for example, mitochondrial activity or the decrease in the number of mitochondria.

Abstract: An active vehicle height control method may include securing a road surface profile for unevenness of a road ahead of a vehicle; forming a target vehicle height profile by filtering the road surface profile; forming, by a controller, a disturbance profile using the road surface profile and the target vehicle height profile; estimating, by the controller, vehicle behavior for the disturbance profile; determining, by the controller, an inverse-phase control force that minimizes the estimated vehicle behavior; and driving, by the controller, an actuator using the inverse-phase control force.

Abstract: Disclosed herein are methods for sterile extraction, drying, storage, and transformation of immature and mature maize and monocot embryos. The present disclosure also describes a dried, storable, freezable value added maize and monocot explants.

Abstract: A system and method for providing a virtual collaborative creation of real-world projects. The system comprises a server configured to store and process input data, the server comprising a memory and a processor, wherein the memory further comprises a database with structured data storing virtual replicas of real-world elements forming a virtual world system, and wherein the processor is configured to execute data and instructions stored in the memory. A plurality of devices connect the server via a network, each device comprising sensing mechanisms configured to capture multi-source data from real-world elements that serve to enrich and synchronize the virtual replicas with corresponding real-world elements. Collaborative platforms stored in the memory and accessed via user devices enable the creation, tender offering, and administrative reviewing and approval or rejection of real-world projects. Methods thereof are also described.

Abstract: A method of performing a class incremental learning in a neural network apparatus, the method including training an autoencoder using first input embeddings with respect to a first class group, calculating a contribution value of each of parameters of the autoencoder and calculating a representative value with respect to each of at least one first class included in the first class group in the training of the autoencoder, retraining the autoencoder using second input embeddings with respect to a second class group, and updating the contribution value of the each of the parameters and calculating a representative value with respect to each of at least one second class included in the second class group in the retraining the autoencoder.

Abstract: A merged reality system comprises at least one server storing a virtual world system comprising one or more virtual objects, the virtual objects including virtual replicas of at least a first location, a second location, and real world elements in the at least first and second locations. The at least one server is configured to receive, from a plurality of connected devices communicating with the at least one server through a network, real-world data from real-world elements in the first and second locations; use the real-world data from the first and second locations in the virtual world system to enrich and synchronize the virtual replicas with corresponding real-world elements; and overlap and stream at least one portion of the real-world data from the second location onto, e.g., one or more surfaces of the virtual replica of the first location.

Abstract: A system and method enabling location-based activation of applications. A server system stores and provides a persistent virtual world system comprising one or more applications virtually attached to virtual-world entities positioned according to real-world coordinates, the server system being configured to compute the state of the virtual-world entities and to process the applications. Upon detecting the user devices in a corresponding zone (e.g., by the wireless network detecting user devices connecting to the server), the server system sends a minimum amount of application graphical representation to the user devices. Upon user interaction with the application graphical representation, the user devices download a minimum amount of application data, prompting the server system to determine suitable application media streams.

Abstract: A method for sensing gas by a gas sensing device, the method may include generating, by a semiconductor temperature sensing element that is spaced apart from a gas reactive element and is thermally coupled to the gas reactive element, detection signals that are indicative of a temperature of the gas reactive element; wherein the gas reactive element and the semiconductor temperature sensing element are of microscopic scale; and processing, by a readout circuit of the gas sensing device, the detection signals to provide information about a gas that affected the temperature of the gas reactive element.

Abstract: A system comprises at least one cloud server of a cloud server computer system comprising at least one processor and memory storing a persistent virtual world system comprising one or more virtual objects including virtual data and models. The virtual objects comprise one or more of a virtual twin, a pure virtual object, or an application, wherein at least one of the virtual objects represents a store of real-world items connected to a periodically-updated database associated to the products of the at least one store. Users may access the store through the persistent virtual world system via a user device enabling interactions with and between elements within the store.

Abstract: A location-based platform for hosting multiple 3D engines delivering location-based 3D content. An engine platform server system is configured to host one or more engine servers hosting 3D engines and to provide an engine platform comprising digital reality applications developed via the 3D engines. The digital reality applications are configured in pre-determined locations within a persistent virtual world system or in mobile virtual replicas of corresponding real-world objects. Client devices approaching a digital reality application send the viewing position and orientation along with a view request to the engine platform server, which requests virtual frames from respective 3D engines, composites each virtual frame into one view, and sends the resulting media stream to users via the client devices.

Abstract: A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein includes first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted. When the heterodimeric Fc-fused protein is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.

Abstract: The present disclosure relates to three-dimensional (3D) printed fluoropolymer-based energetic compositions and 3D printing methods for making the 3D printed fluoropolymer-based energetic compositions.

Abstract: Disclosed are modularized garment manufacturing method and system for small quantity batch production of garments. Basic components constituting an ordered garment are generated by analyzing shape graphic data of the ordered garment. For each basic component, basic patterns are generated for each dimension of the ordered garment. The basic patterns are compared with reference garment patterns stored in a garment pattern database to determine a pattern category of each basic pattern. Based on the pattern category of the basic patterns and information on garment production lines currently in operation, subdivided work modules are determined for each basic pattern.