Patents Assigned to Friedrich-Alexander-Universitat Erlangen-Nurnberg
  • Publication number: 20200384118
    Abstract: The present invention relates to conjugates comprising an immunotoxin linked to a therapeutic agent, wherein said immunotoxin comprises a binding domain fused to an adenosine diphosphate (ADP) ribosylating toxin, pharmaceutical compositions comprising said conjugates, and methods for the preparation of said immunotoxins.
    Type: Application
    Filed: December 18, 2018
    Publication date: December 10, 2020
    Applicant: FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG
    Inventor: Fabian MÜLLER
  • Publication number: 20200377523
    Abstract: The present invention describes a compound of formula (I) which can be used in the diagnosis, treatment or prevention of neurotensin receptor-related conditions such as tumors and hematological malignancies.
    Type: Application
    Filed: August 2, 2017
    Publication date: December 3, 2020
    Applicants: Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen
    Inventors: Olaf PRANTE, Torsten KUWERT, Peter GMEINER, Ashutosh BANERJEE, Simone MASCHAUER
  • Patent number: 10833909
    Abstract: Embodiments provide a receiver having a receiving unit and a synchronization unit. The receiving unit is configured to receive a data packet having a pilot sequence. The synchronization unit is configured to separately correlate the pilot sequence with at least two partial reference sequences corresponding to a reference sequence for the pilot sequence of the data packet, in order to obtain a partial correlation result for each of the at least two partial reference sequences, wherein the synchronization unit is configured to non-coherently add the partial correlation results in order to obtain a coarse correlation result for the data packet.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: November 10, 2020
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN NÜRNBERG
    Inventors: Gerd Kilian, Josef Bernhard, Jörg Robert, Jakob Kneißl
  • Patent number: 10828281
    Abstract: The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: November 10, 2020
    Assignee: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Anja-Katrin Bosserhoff, Alexander Riechers, Burkhard König, Manuel Bause, Fabian Rauscher
  • Publication number: 20200308168
    Abstract: The present invention relates to fluorophenyl substituted muscarinic receptor ligands with selectivity for M3 over M2 and to the use of these compounds in the treatment of various diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD) and urinary incontinence.
    Type: Application
    Filed: December 3, 2018
    Publication date: October 1, 2020
    Applicants: Friedrich-Alexander-Universität Erlangen-Nürnberg, The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Ashutosh BANERJEE, Amelie BARTUSCHAT, Katrin EITEL, Peter GMEINER, Markus HEINRICH, Josefa HOFMANN, Harald HÜBNER, Hannelore RAMPP, Benjamin SCHAAKE, Brian KOBILKA, Roger SUNAHARA, Mary Joyce CLARK, Inbar FISH, Brian SHOICHET
  • Patent number: 10766030
    Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: September 8, 2020
    Assignees: SINAMIRA AG, FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG
    Inventors: Walter Miedl, Oliver Friedrich, Daniel Gilbert
  • Patent number: 10725131
    Abstract: A topologically-protected traveling-wave amplifier includes resonators arranged in a two-dimensional array defining a periphery including a first edge. An output line is coupled to an output resonator disposed along the first edge spaced from an input resonator coupled to an output line. A synthetic gauge field generator associated with the resonators provides a topologically-protected edge state corresponding to propagation along the periphery in a propagation direction from the input resonator along the first edge to the output resonator. A parametric driving element creates pairs of photons in the edge state and amplifies a signal propagating along the first edge in the propagation direction. A signal incident from the input line propagates in the propagation direction along the first edge while being amplified and is detected at the output line as an amplified signal. A signal incident from the output line is attenuated before emerging at the input resonator.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: July 28, 2020
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG
    Inventors: Aashish Clerk, Martin Houde, Florian Marquardt, Vittorio Peano Cavasola
  • Patent number: 10702498
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 7, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG, THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Brian K. Shoichet, Henry Lin, Peter Gmeiner, Aashish Manglik, Brian Kobilka, Bryan L. Roth, Daniela Gisela Dengler
  • Publication number: 20200072841
    Abstract: The present disclosure pertains to the identification of novel biomarkers for the characterization of melanocytic lesions as can be found in skin diseases such as melanomas and psoriasis. In particular, the present invention is directed to a method for characterizing melanocytic lesions and their use in an automated or semi-automated device for the diagnosis and/or monitoring of benign, pre-malignant, and malignant melanocytic lesions, as further defined in the claims.
    Type: Application
    Filed: March 8, 2019
    Publication date: March 5, 2020
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: ANDREAS BAUR, CHRISTAN OSTALECKI, GEROLD SCHULER
  • Patent number: 10530300
    Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: January 7, 2020
    Assignees: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Hans-Martin Tröger, Norbert Franke, Albert Heuberger, Jörg Robert
  • Patent number: 10390754
    Abstract: A method and system for motion estimation modeling for cardiac and respiratory motion compensation is disclosed. Specifically, a coronary sinus catheter is tracked in a plurality of frames of a fluoroscopic image sequence; and cardiac and respiratory motion of a left atrium is estimated in each of the plurality of frames based on tracking results of the coronary sinus catheter using a trained motion estimation model.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 27, 2019
    Assignees: Siemens Healthcare GmbH, FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG
    Inventors: Alexander Benjamin Brost, Sebastian Kaeppler, Martin Ostermeier, Norbert Strobel, Wen Wu, Terrence Chen
  • Patent number: 10370427
    Abstract: The present invention relates to specific T-cell receptor a-chains, T-cell receptor ?-chains and T-cell receptors comprising said T-cell receptor a-chain and/or ?-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or ?-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or ?-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 6, 2019
    Assignee: Friedrich-Alexander Universität Erlangen-Nürnberg
    Inventors: Thomas Harrer, Angela Hückelhoven
  • Patent number: 10359409
    Abstract: A method for detecting a degree of hydrogenation of a liquid comprises one or more liquid hydrogen carriers, which can be hydrogenated, comprising: detecting a material property of the liquid and determining the degree of hydrogenation of the liquid on the basis of the detected material property of the liquid.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 23, 2019
    Assignees: FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, HYDROGENIOUS TECHNOLOGIES GMBH
    Inventors: Wolfgang Arlt, Katharina Stark, Peter Wasserscheid
  • Patent number: 10301247
    Abstract: A method of making acrylic acid in liquid phase by contacting a feed stream containing lactic acid, lactide, or mixtures thereof with a molten salt catalyst comprising a protic ionic liquid (PIL), which contains a bromide anion (Br?), is provided.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: May 28, 2019
    Assignees: The Procter & Gamble Company, Friedrich Alexander Universitat Erlangen-Nurnberg
    Inventors: Jakob Albert, Peter Wasserscheid, Nicola Taccardi, Jens Nagengast, Matthias Kehrer, Julian Kadar, Dimitris Ioannis Collias
  • Patent number: 10301184
    Abstract: The invention relates to a zeolitic material comprising zeolitic monocrystals, each of which has a pore system encompassing at least one micropore system and at least one macropore system, and to a method for producing a zeolitic material of said type. In said method, porous oxide particles are converted into the zeolitic material in the presence of an organic template and steam.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: May 28, 2019
    Assignees: Friedrich-Alexander-Universität Erlangen-Nürnberg, Technische Universität Clausthal
    Inventors: Albert Gonche Fortunatus Machoke, Alexandra Inayat, Wilhelm Schwieger, Ana Maria Beltrán Custodio, Erdmann Spiecker, Robert Güttel, Nadine Kruse
  • Patent number: 10228446
    Abstract: The invention relates to a method for determining the position of a first sensor node relative to a second sensor node, wherein the first and the second sensor nodes are communicatively connected to each other and are a constituent part of a sensor network, comprising the method steps: reception of signal sections of transmitted signals from at least two transmitters by the first and the second sensor node, beginning at a time t1 for a time period tRX; determining the angle of incidence of the transmitted signals to at least one of the sensor nodes; determining the distance between the sensor nodes from the propagation time differences of the transmitted signals from the at least two transmitters received at the first and second sensor nodes; determining the position of the first sensor node relative to the second sensor node from the distance between the sensor nodes and the angle of incidence of the transmitted signals, wherein the sensor nodes determine the time t1 and the time period t1 in relation to a r
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: March 12, 2019
    Assignees: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universitat Erlangen-Nurnberg
    Inventors: Norbert Franke, Gerd Kilian, Christian Forster, Hans-Martin Tröger, Jörn Thielecke, Jörg Robert, Markus Hartmann
  • Publication number: 20190052227
    Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.
    Type: Application
    Filed: February 15, 2017
    Publication date: February 14, 2019
    Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Hans-Martin Tröger, Norbert Franke, Albert Heuberger, Jörg Robert
  • Publication number: 20180339293
    Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 29, 2018
    Applicants: SINAMIRA AG, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG
    Inventors: Walter MIEDL, Oliver FRIEDRICH, Daniel GILBERT
  • Publication number: 20180259566
    Abstract: A measurement method is for determining core losses, which serve to produce magnetic circuits for electrical machines. In order to allow an accurate measurement that is as quick as possible, it is proposed that a magnetic coupling is produced between a measuring coil connected in a capacitor and a core to be measured, and the measuring coil is then acted upon by an alternating frequency in order to measure the resonant frequency of the resulting resonant circuit and/or the quality of the resulting resonant circuit as a measure of the core loss.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Michael SCHNEIDER, Jörg FRANKE
  • Publication number: 20180230486
    Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
    Type: Application
    Filed: December 4, 2017
    Publication date: August 16, 2018
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Katrin BIRKHOLZ, Jan DÖRRIE, Niels SCHAFT, Gerold SCHULER, Reinhard VOLL, Isabell PFEIFFER