Patents Assigned to Fujirebio Europe N.V.
  • Antibodies to phosphorylated tau aggregates
    Patent number: 9447179
    Abstract: This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: September 20, 2016
    Assignees: KATHOLIEKE UNIVERSITEIT LEUVEN, KU RESEARCH & DEVELOPMENT, FUJIREBIO EUROPE N.V.
    Inventors: Joris Winderickx, Eugeen Vanmechelen, Fred Van Leuven
  • Detection, identification and differentiation of eubacterial taxa using a hybridization assay
    Patent number: 9273361
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: March 1, 2016
    Assignees: FUJIREBIO EUROPE N.V., ROCHE DIAGNOSTICS GMBH
    Inventors: Hilde De Henau, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Detection, identification and differentiation of using a hybridization assay
    Patent number: 8945850
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: February 3, 2015
    Assignees: Fujirebio Europe N.V., Roche Diagnostics GmbH
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Method for typing and detecting HBV
    Patent number: 8859203
    Abstract: The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT pol gene region and/or to a mutant target sequence chosen from the HBV preCore region and/or to a mutant target sequence chosen from the HBsAg region of HBV and/or to a HBV genotype-specific target sequence, with said target sequences being chosen from FIG.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: October 14, 2014
    Assignee: Fujirebio Europe N.V.
    Inventors: Lieven Stuyver, Rudi Rossau, Geert Maertens
  • Method for typing and detecting HBV
    Patent number: 8835106
    Abstract: The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT pol gene region and/or to a mutant target sequence chosen from the HBV preCore region and/or to a mutant target sequence chosen from the HBsAg region of HBV and/or to a HBV genotype-specific target sequence, with said target sequences being chosen from FIG.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: September 16, 2014
    Assignee: Fujirebio Europe N.V.
    Inventors: Lieven Stuyver, Rudi Rossau, Geert Maertens