Patents Assigned to Fujisawa Pharmaceutical Co., Ltd.
  • Publication number: 20050043371
    Abstract: This invention relates to new aminoalcohol derivatives or salts thereof represented by the following formula [I]: wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic, anti-urinary incontinence and anti-pollakiuria activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.
    Type: Application
    Filed: October 7, 2004
    Publication date: February 24, 2005
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Kiyoshi Taniguchi, Naoaki Fujii, Minoru Sakurai, Yasuyo Tomishima, Hisashi Takasugi
  • Publication number: 20050043358
    Abstract: A compound of the formula (I): wherein X1 is bond or —OCH2—; X2 is —(CH2)n—, in which n is 1, 2 or 3; X3 is bond, —O—, —S—, —OCH2—, or —NH—; R1 is phenyl or pyridyl each of which may have one or two substituent(s) selected from the group consisting of hydroxy, halogen, etc.; R2 is hydrogen, (lower)alkoxycarbonyl, etc.; R3 is hydroxy(lower)alkyl; halo(lower)alkyl, etc.; R4 is aryl or unsaturated heterocyclic group, each of which may have one or two substituent(s) selected from the group consisting of lower alkyl, hydroxy, carbamoyl, halogen, lower alkoxy, etc.; and a salt thereof which is useful as a medicament.
    Type: Application
    Filed: December 29, 2003
    Publication date: February 24, 2005
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Takeshi Kato, Naoaki Fujii, Kenichi Washizuka, Yasuyo Tomishima, Hisashi Takasugi, Yutaka Kohno, Nobuhiro Yamamoto, Naoko Unami, Hirohumi Ishikawa
  • Publication number: 20050027121
    Abstract: This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
    Type: Application
    Filed: November 24, 2003
    Publication date: February 3, 2005
    Applicant: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Miyake, Kazuhiko Take, Shinji Shigenaga, Hidenori Azami, Hiroshi Sasaki, Yoshiteru Eikyu, Kazuo Nakai, Junya Ishida, Takashi Manabe, Nobukiyo Konishi, Tadashi Terasaka
  • Publication number: 20050014812
    Abstract: The present invention provides novel benzimidazole compounds of the formula (I): wherein each symbol is as defined in the specification, salts thereof and prodrugs thereof, which are useful in treating, for example, the diseases curable through decrease in blood sugar level.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 20, 2005
    Applicants: Fujisawa Pharmaceutical Co., Ltd., Daicel Chemical Industries, Ltd.
    Inventors: Hisashi Hayashida, Keiko Hatanaka, Takeshi Kato, Yoshiyuki Kido, Masaki Tomishima, Hiroshi Kayakiri, Ichiro Takase, Takahiro Hiramura
  • Publication number: 20050014685
    Abstract: This invention relates to new lipopeptide compound represented by the following general formula (I): Wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Application
    Filed: June 23, 2004
    Publication date: January 20, 2005
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroaki Mizuno, Hiroshi Matsuda, Takahiro Matsuya, David Barrett
  • Publication number: 20050004094
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 28, 2004
    Publication date: January 6, 2005
    Applicants: Fujisawa Pharmaceutical Co., Ltd., WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Toshio Yamanaka, Hidenori Ohki, Masaru Ohgaki, Shinya Okuda, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Publication number: 20050004014
    Abstract: This invention relates to new lipopeptide compound represented by the following general formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 6, 2005
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Takahiro Matsuya, Hiroaki Mizuno, Takashi Tojo, Hiroshi Matsuda, David Barrett
  • Publication number: 20040266774
    Abstract: The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 30, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Kiyotaka Ito, Glen W. Spears, Fumie Takahashi, Akira Yamada, Masaki Tomishima, Hiroshi Miyake
  • Publication number: 20040259923
    Abstract: A compound of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.
    Type: Application
    Filed: January 27, 2004
    Publication date: December 23, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Takayuki Inoue, Takashi Tojo, Masataka Morita, Mitsuru Ohkubo, Kousei Yoshihara, Akira Nagashima
  • Patent number: 6833353
    Abstract: A new use of immunosuppressant for treating or preventing MMp-medicated diseases is provided. The preferred immunosuppresants are tacrolimus, cyclosporing A or 33-epi-chloro-33-desoxyascomycin (pimecrolimus). Particularly, preferable MMP-mediated diseases are the diseases or conditions caused by gelatinase and/or collagenase, and/or inflammatory diseases concerned with gelatinase; such as arthritis (e.g., osteoarthritis, rheumatoid arthritis, etc.) cerebral diseases (e.g., stroke, etc.), tissue ulceration (e.g., corneal, epidermal and gastriculceration, etc.), abnormal wound healing, periodontal diseases, bone diseases (e.g., Paget's diseases, osteoporosis. etc.), tumor growth, tumor metastasis or invasion, HIV-infection, decubitus, decubitis ulcer, restenosis, epidermolysis bullosa, sepsis, septic shock, neoplasm, psoriasis, neovascularization and multiple sclerosis.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: December 21, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Nobuchika Yamamoto, Harumi Yamazaki, Takeshi Ishikawa, Shigeru Johki, Fumihiko Sakai
  • Patent number: 6825200
    Abstract: The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: November 30, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
  • Patent number: 6825018
    Abstract: A gene encoding D-sorbitol dehydrogenase (SLDH); a process for producing SLDH by culturing host cells transformed by an expression vector having the above gene; and a process for processing L-sorbose or 2-keto-L-gulonic acid (2KLGA) by using the above culture. 2KLGA is an important intermediate in the production of L-ascorbic acid. Thus, a process for producing L-ascorbic acid from the 2KLGA obtained by the above process is also provided.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: November 30, 2004
    Assignee: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Takashi Shibata, Chiyo Ichikawa, Mitsutaka Matsuura, Yuji Noguchi, Yoshimasa Saito, Michio Yamashita, Yoko Takata
  • Patent number: 6825003
    Abstract: The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: November 30, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Patent number: 6826033
    Abstract: The present invention relates to a compound formula (I) wherein X1 is bond or —O—CH2—, (II) or (III) R1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: November 30, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Minoru Sakurai, Kenichi Washizuka, Hitoshi Hamashima, Yasuyo Tomishima, Masashi Imanishi, Yutaka Nakajima, Hiroaki Ohtake, Satoru Kuroda, Masayoshi Murata, Hiroshi Kayakiri, Naoaki Fujii, Kiyoshi Taniguchi
  • Publication number: 20040235105
    Abstract: The present invention provide a gene encoding D-sorbitol dehydrogenase (SLDH), a method for producing SLDH by culture of a host cell transformed with a vector expressing this gene and a method for producing L-sorbose or 2-keto-L-gulonic acid (2KLGA) using the culture. 2KLGA is an important intermediate for the production of L-ascorbic acid. Therefore, the present invention also provides a method for producing L-ascorbic acid from the 2KLGA obtained by the above-mentioned method.
    Type: Application
    Filed: May 13, 2004
    Publication date: November 25, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Takashi Shibata, Chiyo Ichikawa, Mitsutaka Matsuura, Yuji Noguchi, Yoshimasa Saito, Michio Yamashita, Yoko Takata
  • Publication number: 20040229889
    Abstract: A compound having the following formula (I): 1
    Type: Application
    Filed: January 12, 2004
    Publication date: November 18, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Yasuharu Urano, Shigeki Satoh, Naoki Ishibashi, Kazunori Kamijo
  • Patent number: 6812235
    Abstract: A beta-alanine derivative of the formula (I) wherein R1 is hydrogen atom or an amino protective group; A is a lower alkylene group or a lower alkenylene group; R2 is hydrogen atom or an amino group which may be substituted with an acyl group; R3 is hydrogen atom or an aryl or aralkyl group which may be substituted with one or more of hydroxy and/or lower alkoxy, a moiety represented by the formula (II), which is a bivalent N-containing 6- to 8-membered heterocyclic group, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: November 2, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Mitsuru Ohkubo, Satoru Kuroda, Hideko Nakamura, Masatoshi Minagawa, Toshiaki Aoki, Kayoko Harada, Jiro Seki
  • Publication number: 20040214218
    Abstract: A novel means for DNA compaction is provided.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 28, 2004
    Applicants: Fujisawa Pharmaceutical Co., Ltd., Eiichi NAKAMURA
    Inventors: Eiichi Nakamura, Masaya Sawamura, Hiroyuki Isobe
  • Publication number: 20040180947
    Abstract: A sulfonamide compound of the formula (I):
    Type: Application
    Filed: March 30, 2004
    Publication date: September 16, 2004
    Applicant: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Tsuyoshi Mizutani, Teruo Oku, Noritsugu Yamasaki, Osamu Onomura, Masahiro Nishikawa, Takahiro Hiramura, Takafumi Imoto
  • Patent number: 6787565
    Abstract: A sulfonamide compound of the formula (I): R1—SO2NHCO—A—X—R2  (I) wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: September 7, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Tsuyoshi Mizutani, Teruo Oku, Noritsugu Yamasaki, Osamu Onomura, Masahiro Nishikawa, Takahiro Hiramura, Takafumi Imoto