Patents Assigned to Fujisawa Pharmaceutical Company, Limited
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Patent number: 5519049Abstract: Compositions comprising certain macrolides are disclosed which are useful in methods for the treatment of reversible obstructive airway diseases, particularly asthma.Type: GrantFiled: July 16, 1993Date of Patent: May 21, 1996Assignees: Fisons plc, Fujisawa Pharmaceutical Company LimitedInventors: Alan A. Norris, Dale M. Jackson, Sohei Makino, Takeshi Fukuda, Ikuo Akutsu
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Patent number: 5210227Abstract: Compounds of formula I, ##STR1## wherein R.sup.1 represents H, OH, protected OH or alkoxy; R.sup.2 represents H; R.sup.3 represents O or (H,OH); R.sup.4 represents methyl, ethyl, propyl or allyl; R.sup.5 represents OH, protected OH or alkoxy; R.sup.6 represents OH; R.sup.7 represents OH, alkoxy or NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 independently represent H, alkyl or aryl; in addition, R.sup.1 and R.sup.2 may together represent a second bond between the carbon atoms to which they are attached; and R.sup.6 and R.sup.7 may together represent O; and pharmaceutically acceptable salts thereof; are useful inter alia as immunosuppressive agents. The invention also provides the novel compounds of formula I.Type: GrantFiled: February 27, 1991Date of Patent: May 11, 1993Assignees: Fisons plc, Fujisawa Pharmaceutical Company LimitedInventors: Hirokazu Tanaka, Martin E. Cooper, David K. Donald
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Patent number: 4841062Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is cyclo(lower)alkyl or lower alkynyl having 2 to 6 carbon atoms, andR.sup.6 is amino or protected amino, or the reactive derivative at the carboxy group, are disclosed as intermediates for the preparation of cephem and cepham compounds having antimicrobial activity.Type: GrantFiled: February 11, 1988Date of Patent: June 20, 1989Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4822888Abstract: A compound of the formula: ##STR1## wherein R.sup.2 is halo(lower)alkyl, andR.sup.6 is amino or protected amino, its reactive derivative at the carboxy group or its lower alkyl ester, is disclosed, having utility as an intermediate for producing cephems or cephams.Type: GrantFiled: February 19, 1986Date of Patent: April 18, 1989Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyosha Tsuji, Toshiyuki Chiba
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Patent number: 4604456Abstract: 7-substituted 3-cephem or cepham compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and A is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.Type: GrantFiled: October 19, 1983Date of Patent: August 5, 1986Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4425341Abstract: 7-Substituted 3-cephem or cephem compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and a is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.Type: GrantFiled: March 14, 1978Date of Patent: January 10, 1984Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4400379Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is an aliphatic hydrocarbon residue substituted with halogen, carboxy or esterified carboxy,R.sup.4 is halogen or a group of the formula:--O--R.sup.7, in which R.sup.7 is lower alkyl,R.sup.5 is carboxy or functionally modified carboxy andR.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making the compounds, pharmaceutical compositions containing them and their use to treat infectious diseases.Type: GrantFiled: September 15, 1981Date of Patent: August 23, 1983Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4399133Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.1 is thiadiazolyl,R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy andR.sup.5 is carboxy or functionally modified carboxy, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.Type: GrantFiled: September 15, 1981Date of Patent: August 16, 1983Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4393059Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon which may be substituted with halogen, carboxy or pharmaceutically acceptable esterified carboxy,R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy,R.sup.6 is amino or protected amino andR.sup.7 is lower alkanesulfonyl or arenesulfonyl and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.Type: GrantFiled: September 15, 1981Date of Patent: July 12, 1983Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hisashi Takasugi, Kiyoshi Tsuji, Toshiyuki Chiba
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Patent number: 4363807Abstract: This invention relates to novel cepham compounds of antimicrobial activity, useful as intermediates in the preparation of antibiotics, said novel cepham compounds being of the formula: ##STR1## wherein R.sup.1 is phenyl (lower) alkanoylamino, phenoxy (lower) alkanoylamino or aminothiazolyl (lower) alkanoylamino substituted with a lower alkoxyimino group,R.sup.2 is carboxy or a protected carboxy group,R.sup.3 is formyl, hydroxymethyl or acyloxymethylene, andX is --S-- or --SO--, and its salt.Type: GrantFiled: October 17, 1979Date of Patent: December 14, 1982Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Takashi Masugi, Toshiyuki Chiba
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Patent number: 4339449Abstract: A compound of high antimicrobial activity of the formula: ##STR1## in which R.sup.1 is amino or a substituted amino group andR.sup.2 is hydrogen or lower alkoxy, orR.sup.1 and R.sup.2 are combined together to form a group of the formula: ##STR2## wherein R.sup.6 and R.sup.7 are each hydrogen or lower alkyl, andA is a group of the formula: ##STR3## wherein X is --S-- or ##STR4## R.sup.3 is carboxy or a protected carboxy group and R.sup.4 is hydrogen, hydroxy or acyl,and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 10, 1980Date of Patent: July 13, 1982Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Masashi Hashimoto, Matsuhiko Aratani
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Patent number: 4292320Abstract: A 1,2,3,4-tetrahydroisoquinoline having smooth muscle relaxant activity of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or lower alkyl and X is --O-- or --S--, and pharmaceutically acceptable salts thereof.Type: GrantFiled: August 17, 1979Date of Patent: September 29, 1981Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Teiji Kishimoto, Hiromu Kochi, Yoshiyuki Kaneda
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Patent number: 4246405Abstract: A process for preparing a 7-substituted-3-cephem-4-carboxylic acid of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which comprises subjecting a corresponding 7-substituted-3-organic sulfonyloxy-3-cephem-4-carboxylic acid ester of the formula ##STR2## wherein R is a residue of an organic sulfonic acid, X is esterified carboxy which is an alkoxylcarbonyl, haloalkoxycarbonyl, substituted or unsubstituted aralkoxycarbonyl, benzhydryloxycarbonyl or trityloxycarbonyl, or a pharmaceutically acceptable salt thereof,to hydrogenolysis using a combination of a metal and formic acid as a reducing reagent.Type: GrantFiled: June 1, 1978Date of Patent: January 20, 1981Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takao Takaya, Hiromu Kochi, Takashi Masugi
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Patent number: 4234724Abstract: Cephalosporin analogues represented by the formula ##STR1## wherein R.sup.1 is amino or a substituted amino,R.sup.2 is carboxy or a protected carboxy, andR.sup.3 is hydrogen or lower alkoxy, processes for making the same, azetidinone intermediates and pharmaceutical compositions comprising said cephalosporin analogues as active ingredients.Type: GrantFiled: December 22, 1978Date of Patent: November 18, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Masashi Hashimoto, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Daijiro Hagiwara
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Patent number: 4225707Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.2 is carboxy or a protected carboxy group,R.sup.4 is hydrogen or lower alkyl andY is a residue of an acid, or a salt.Type: GrantFiled: February 26, 1979Date of Patent: September 30, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Takao Takaya
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Patent number: 4218374Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.Type: GrantFiled: April 23, 1979Date of Patent: August 19, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku
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Patent number: 4206156Abstract: New hydroxyaminohydrocarbonphosphonic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or acyl,R.sup.2 is hydrogen, lower alkyl, ar(lower)alkyl or acyl, andA is lower alkylene, lower alkenylene or hydroxy(lower)alkylene,or the esters at the phosphono group thereof or the pharmaceutical acceptable salt thereof, and production and use thereof.Type: GrantFiled: April 17, 1978Date of Patent: June 3, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Masashi Hashimoto, Keiji Hemmi, Hidekazu Takeno
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Patent number: 4203897Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is amino or a conventional, pharmaceutically acceptable acylamino, R.sup.2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR2## R.sup.3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido, thiocyanato, lower alkyanoylthio and piperidinothiocarbonylthio.Type: GrantFiled: April 23, 1979Date of Patent: May 20, 1980Assignee: Fujisawa Pharmaceutical Company, LimitedInventors: Takashi Kamiya, Tsutomu Teraji, Masashi Hashimoto, Osamu Nakaguti, Teruo Oku