Patents Assigned to Fundaçao Oswaldo Cruz - FIOCRUZ
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Patent number: 11129561Abstract: This invention relates to a device that is intended to synchronize electroencephalograms (EEGs), recorded by any digital equipment, to physical events (sensorial, visual or auditory stimuli) and behavioral events (motor response, vocal response), in order to allow EEG signal mediation for the purpose of visualizing Evoked Potentials or Event-Related Potentials, which are important research subjects in the neurosciences and clinical investigations into neurological and psychiatric pathologies. This invention allows any digital EEG device to be transformed into equipment that can record Evoked Potentials. This invention also provides a method for analog synchronization of EEGs with oscillating electric light-related events and motor behaviors.Type: GrantFiled: March 17, 2017Date of Patent: September 28, 2021Assignee: FUNDAÇÂO OSWALDO CRUZ (FIOCRUZ)Inventors: Dimitri Marques Abramov, Paulo Ricardo Galhanone, Marcos Antonio Dias Lima, Carlos Henrique Quintanilha Martins
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Patent number: 10314900Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: GrantFiled: January 9, 2018Date of Patent: June 11, 2019Assignees: The United States of America, as represted by the Secretary, Department of Health and Human Services, Fundaçao Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Patent number: 10286059Abstract: The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of nucleotides encoding whole or part of heterologous proteins, through the following method: (a) modification of the heterologous nucleotides sequences in such way that when cloned and expressed in a vector virus, the 5? region nucleotides present in the 5? edge of the gene NS1 of this vector virus or of other virus or equivalent functional sequences, and in its 3? region, the correspondent genome region in the whole or part of the domains of the stem and anchor of the protein E of the vector virus or equivalent functional sequences, and not comprising the structure and the replication of the mentioned vector virus; (b) insertion of the modified heterologous sequences in (a) in the intergenic region at the structural protein E level and of the nonstructural NS1 vector virus; (c) obtaining the non pathogenic recombinant virus with immunologic properties, having the heterologous sequencesType: GrantFiled: December 14, 2016Date of Patent: May 14, 2019Assignee: Fundacao Oswaldo Cruz-FiocruzInventors: Myrna Cristina Bonaldo, Ricardo Galler
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Patent number: 10065927Abstract: The instant invention relates to compounds of formula I wherein: R is selected from H, Me or Cl, and R? is selected from: H, NH2, NHCOCH3 NHCOCF3 or NHCOCH2Cl. The invention further provides a process for obtaining the compounds of formula I and their use.Type: GrantFiled: January 14, 2016Date of Patent: September 4, 2018Assignee: FUNDACÃO OSWALDO CRUZ (FIOCRUZ)Inventors: Núbia Boechat, Frederico Silva Castelo Branco
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Publication number: 20180186867Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.Type: ApplicationFiled: February 20, 2018Publication date: July 5, 2018Applicants: U.S. Government represented by the Department of Veterans Affairs, The Regents of the University of California, Cornell Research Foundation, Inc., Fundação Oswaldo Cruz - FIOCRUZInventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
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Publication number: 20180147269Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: ApplicationFiled: January 9, 2018Publication date: May 31, 2018Applicants: The Government of the United States of America as represented by the Secretary of the Department of, Fundaçao Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Patent number: 9884100Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.Type: GrantFiled: June 7, 2016Date of Patent: February 6, 2018Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundacão Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Publication number: 20170232082Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.Type: ApplicationFiled: April 28, 2017Publication date: August 17, 2017Applicant: Fundaçao Oswaldo Cruz - FIOCRUZInventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
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Patent number: 9670256Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.Type: GrantFiled: November 12, 2014Date of Patent: June 6, 2017Assignee: Fundacao Oswaldo Cruz-FIOCRUZInventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
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Publication number: 20170037114Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.Type: ApplicationFiled: October 25, 2016Publication date: February 9, 2017Applicants: U.S. Government represented by the Department of Veterans Affairs, The Regents of the University of California, Cornell Research Foundation, Inc., Fundação Oswaldo Cruz - FIOCRUZInventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
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Publication number: 20160279211Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.Type: ApplicationFiled: June 7, 2016Publication date: September 29, 2016Applicants: The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S, Fundaçao Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Publication number: 20160222069Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.Type: ApplicationFiled: April 20, 2016Publication date: August 4, 2016Applicants: U.S. Government represented by the Department of V eterans Affairs, The Regents of the University of California, Cornell Research Foundation, Inc., Fundação Oswaldo Cruz - FIOCRUZInventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
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Patent number: 9382302Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: GrantFiled: July 17, 2015Date of Patent: July 5, 2016Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Publication number: 20150315254Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: ApplicationFiled: July 17, 2015Publication date: November 5, 2015Applicants: The Government of the United States of America as represented by the Secretary of the Department of, Fundacao Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
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Publication number: 20150064211Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.Type: ApplicationFiled: November 12, 2014Publication date: March 5, 2015Applicant: FUNDAÇAO OSWALDO CRUZ - FIOCRUZInventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
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Publication number: 20140308734Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.Type: ApplicationFiled: May 19, 2014Publication date: October 16, 2014Applicants: The United States Government represented by the Department of Veterans Affairs, The Regents of the University of California, Cornell Research Foundation, Inc., Fundação Oswaldo Cruz - FIOCRUZInventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
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Publication number: 20140093531Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: ApplicationFiled: December 5, 2013Publication date: April 3, 2014Applicants: Fundacao Oswaldo Cruz (FIOCRUZ), The Government of the United States of America as represented by the Secretary of the Department ofInventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Netto, Claudia I. Brodskyn, Regis Gomes
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Patent number: 8628780Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.Type: GrantFiled: January 7, 2009Date of Patent: January 14, 2014Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
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Publication number: 20130230903Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.Type: ApplicationFiled: April 24, 2013Publication date: September 5, 2013Applicants: The United States Government represented by the Department of Veterans Affairs, Fundação Oswaldo Cruz - FIOCRUZ, Cornell Research Foundation, Inc., The Regents of the University of CaliforniaInventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
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Publication number: 20130137187Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using peptide fragments.Type: ApplicationFiled: November 1, 2012Publication date: May 30, 2013Applicant: Fundaçao Oswaldo Cruz - FIOCRUZInventor: Fundaçao Oswaldo Cruz - FIOCRUZ