Patents Assigned to Fundaco Oswaldo Cruz-Fiocruz
  • Yellow fever infectious cDNA and plasmids
    Patent number: 6171854
    Abstract: The present invention is related to a vaccine composition for humans against YF infections consisting essentially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious cDNA. There are provided new plasmids, pYF 5′3′ IV/G1/2 and pYFM 5.2/T3/27, which together, have the complete sequence of said YF infectious cDNA. The method for producing recombinant YF virus and the Original, Primary and Secondary Seed Lots are other embodiments of the present invention.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: January 9, 2001
    Assignee: Fundaco Oswaldo Cruz-Fiocruz
    Inventors: Ricardo Galler, Marcos Da Silva Freire