Patents Assigned to G&P BIOSCIENCE CO., LTD.
  • Publication number: 20210163575
    Abstract: The present disclosure relates to an expression vector that carries a polynucleotide coding for a coagulation factor VIII mutant and has increased protein expression and a pharmaceutical composition containing the expression vector for preventing or treating hemorrhagic disease or hemorrhage. The factor VIII mutant of the present disclosure is derived by deleting a part of the B-domain (residues 784-1667) and a part of the a3 region (residues 1668-1671) in factor VIII and, as a result, an expression vector carrying a polynucleotide coding for the factor VIII mutant has remarkably increased protein expression.
    Type: Application
    Filed: December 5, 2018
    Publication date: June 3, 2021
    Applicants: G&P BIOSCIENCE CO., LTD., REYON PHARMACEUTICAL CO., LTD.
    Inventors: Seong-Hyun HO, Su Jin PARK
  • Publication number: 20210113668
    Abstract: The present disclosure relates to a composition for increasing the expression of a growth factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with a growth factor gene, the composition for increasing the expression of a growth factor gene of the present disclosure can increase the expression of the co-administered gene by at least 30%. Especially, when administered along with at least one gene selected from a human hepatocyte growth factor (HGF) gene, an isoform gene of the human hepatocyte growth factor and a variant gene thereof, or at least one gene selected from a human insulin-like growth factor 1 (IGF1) gene, an isoform gene of the human insulin-like growth factor 1 and a variant gene thereof, which are appropriate for the present disclosure, the composition can increase the expression of the gene by at least 30%.
    Type: Application
    Filed: February 12, 2019
    Publication date: April 22, 2021
    Applicants: G&P BIOSCIENCE CO., LTD., REYON PHARMACEUTICAL CO., LTD.
    Inventors: Seong-Hyun HO, Su Jin PARK
  • Publication number: 20210113480
    Abstract: The present disclosure relates to a composition for increasing the expression of a blood coagulation factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with blood coagulation factor VIII gene or a variant gene thereof, the composition for increasing the expression of a blood coagulation factor gene of the present disclosure can increase the expression of the gene by at least 30%. When administered along with a gene therapeutic agent, the composition can achieve a therapeutic effect even with a very small amount of a gene, and thus is useful.
    Type: Application
    Filed: February 12, 2019
    Publication date: April 22, 2021
    Applicants: G&P BIOSCIENCE CO., LTD., REYON PHARMCEUTICAL CO., LTD.
    Inventors: Seong-Hyun HO, Su Jin PARK