Abstract: A chain-of-custody bag is disclosed which provides for the sealing of a specimen taken at a remote location within the bag for transportation to an analysis site. The specimen bag advantageously includes a specimen label conveniently mounted to the specimen bag which is removable therefrom for use on the specimen when placed in the specimen bag. More specifically, the specimen label is provided on top of a protective backing layer that is further provided to cover an adhesive band that acts as the closure for sealing the bag once a specimen is placed therein. The result is that the specimen label can be conveniently located on the bag to be adhered to the specimen and inserted within the bag, and the bag can be sealed thereafter.