Patents Assigned to GE Healthcare Bio-Sciences AB
  • Patent number: 10670569
    Abstract: Disclosed is a fluid path network (100) comprising plural fluid paths (110) interconnected by plural nodal chambers (120), three or more of said plural paths opening into each of said chambers, and said chambers being adapted the accept a removable fluid path modifying insert (130/140/150 FIGS. 3a-3c). The network is employed in a chromatography system described herein.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 2, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Bjorn Markus Olovsson
  • Patent number: 10663461
    Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: May 26, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Markku Hamalainen, Hakan Roos
  • Patent number: 10658072
    Abstract: The present invention relates to a method of evaluation of molecular binding interactions at a sensing surface, and more particularly to a method for evaluation of screening data obtained from an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor that is independent of interaction models. Preferably the biosensor is a SPR biosensor. The invention also relates to a biosensor system arranged to perform the method and a computer program arranged to control the operation of the biosensor system.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: May 19, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Robert Karlsson
  • Patent number: 10625210
    Abstract: A method and a system for improving mixing of content in a container 3 provided in a filter system 1, said method comprising providing a mixing loop 13 parallel to a recirculation flow path 11 of the filter system 1.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: April 21, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Partha Sarathy Doddapadam Srinivasa Raghavachar, Narendra G R, Nachiket Karmarkar, Ajit S. Vernekar, Prashanth Hosabettu Mohan, Sasi Kumar Nutalapati
  • Publication number: 20200116678
    Abstract: A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 16, 2020
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Klaus Gebauer, Jan Kranse, Mats Lundkvist
  • Patent number: 10620172
    Abstract: The present invention relates to a method for performing liquid chromatography purification of one or more target molecules from a sample comprising: providing an eluent flow having one or more target molecules, measuring an output parameter indicative of the content of the one or more target molecules in the eluent flow, storing output parameter data, and dividing the eluent flow into consecutive eluent fractions, dividing the output parameter data into corresponding data fractions, in each data fraction obtaining a value indicative of characteristic behavior of the measured output parameter, identifying trends in the measured output parameter based upon the obtained value in consecutive data fractions, and identifying peak(s) in the measured output parameter correlated to eluent fractions based upon the identified trends, whereby information of identified peak(s) and correlated eluent fraction(s) can be presented and purified sample(s) from the eluent may be collected.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: April 14, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Lena Nyholm, Lotta Hedkvist, Johan Arthursson, Eva Cecilia Olsson, Henrik Larsson
  • Patent number: 10605710
    Abstract: The present invention relates to the preparation of liquid mixtures, and more particularly to the preparation of a liquid mixture, such as a buffer, wherein the conductivity of the liquid mixture is measured and the pH indirectly determined if the buffer concentration is known. Another object of the present invention is to provide a method of preparing a liquid mixture with a predetermined pH value by using conductivity as feedback control parameter.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 31, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Enrique Napoleon Carredano, Elenor Strandberg
  • Patent number: 10598638
    Abstract: A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Olovsson, Karol Lacki, Mikael Berg
  • Patent number: 10598631
    Abstract: Method for electrophoretic separation using a separation gel arrangement with a gel member and one or more sample wells for receiving sample liquid to be separated, the sample wells being in fluidic contact with the gel member, the method comprising the steps: adding a sample liquid to be separated in one or more of the sample wells, applying an electric field over the gel member to drive an electrophoretic separation process, whereby sample constituents are drawn from the sample liquid in the sample well(s) into the gel member for separation, and when a removal criteria is met: discontinuing loading of sample constituents into the separation gel.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Kjell Larsson
  • Patent number: 10598640
    Abstract: The invention discloses a method for correcting a baseline in a chromatogram obtained using a buffer with at least one UV-absorbing component which is a weak acid or a weak base.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Gunnar Malmquist, Martin Hall, Nils Stafstrom
  • Patent number: 10598678
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: March 24, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Publication number: 20200087605
    Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
    Type: Application
    Filed: September 27, 2019
    Publication date: March 19, 2020
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
  • Patent number: 10589239
    Abstract: High accuracy mixing of fluids in a disposable fluid processing system with at least two pumps is provided by a method where a calibration fluid volume is pumped through each pump via a flow meter at at least one calibration pump speed while registering the flow rate using data output from the flow meter, a pump calibration function is calculated from the calibration pump speed and flow rate data and two or more operation fluids are mixed to a predetermined mixture ratio and predetermined flow rate by controlling the pump speed of the respective pumps in accordance with the pump calibration functions.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: March 17, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Patric Fricking, Bjorn Jaderlund
  • Patent number: 10578625
    Abstract: The present invention relates to the field of proteomics and more specifically to a method for analyzing a sample possible containing peptides or modified peptides; in particular useful for biomarker discovery or validation of biomarkers. The method uses isoelectric focusing and mass spectrometry (MS) and enables identification of modified peptides with high resolution and predictability.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: March 3, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Peter Mats Oliviusson, Janne Lehtio, Rui Miguel Mamede-Branca
  • Patent number: 10571033
    Abstract: Disclosed is a rotary valve 1 comprising a stator 20 and a rotor 40 generally in rotary sliding engagement with the said stator about a valve axis RA, the stator including a plurality of fluid ports 22, 26, 28, the rotor 40 being operable to selectively fluidically interconnect two or more of said ports during its rotary sliding engagement. The valve further includes an actuator (70) for disengagement of the rotor from the stator to enable efficient cleaning of the valve interconnections.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 25, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Bjorn Olovsson
  • Patent number: 10571441
    Abstract: The invention discloses a piston for a process column, said piston comprising a top side and a bed contact side, wherein said top side comprises a drainage trench.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 25, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Bergstrom, Stefan Kjell Eriksson
  • Patent number: 10561997
    Abstract: A mixing unit (100) for mixing of fluids is disclosed. The mixing unit (100) includes a mixing chamber (102) for holding one or more fluids and a driving assembly (104) operatively engaged to the mixing chamber (102). The driving assembly (104) is configured to oscillate the mixing chamber (102) for mixing the one or more fluids. The mixing chamber (102) of the mixing unit (100) enables better mixing of fluids in a convenient manner. Further less amount of cleaning fluids may be only required for cleaning the mixing chamber (102) after the mixing process. The mixing unit (100) can be used for mixing amino acids with different fluids however this unit can be used for mixing other fluids as well.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: February 18, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Olovsson, Daniel Carlsson, Mahias Osmark, Magnus Gamberg
  • Patent number: 10551303
    Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: February 4, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Hakan Frojdh, Mikael Hornqvist, Stig Tormod, Patrik Akerstrom
  • Patent number: D886994
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 9, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Mats Lundkvist, Bjorn A. Johansson, Tim Francois
  • Patent number: D886995
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 9, 2020
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Mats Lundkvist, Bjorn A. Johansson, Tim Francois