Patents Assigned to GE Healthcare Bio-Sciences AB
  • Patent number: 10184923
    Abstract: The invention relates to a chromatography column frame comprising at least two legs, a support arrangement connected to said at least two legs, and a holder means connected to said support arrangement. Said holder means is arranged to releasably hold an adaptor rod of a chromatography column, so that the adaptor rod is prevented to move in a horizontal direction and so the adaptor rod is allowed to move in a vertical direction. The invention also relates to method of conducting maintenance on and packing of a chromatography column.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: January 22, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Haglund, Cheng Jiang, Martin Kling
  • Patent number: 10185088
    Abstract: Disclosed is an optical fiber arrangement for inducing coupling among propagation modes of light, said arrangement comprising a multimode optical fiber (30) having an input end (32) for receiving light and an output end (31) for emitting light, with a coupling inducing section (33) extending from said input end to said output end, and a holder (80) on which the optical fiber is arranged, wherein said multimode optical fiber has a non-circular cross section. Disclosed also is a system for measuring the absorption or determining the concentration of a substance, said system comprising at least one optical fiber arrangement.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 22, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Hanno Ehring, Siavash Yazdanfar, Mikael Anders Hornqvist, Zhangyi Zhong, Ying Mao
  • Patent number: 10183236
    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the center of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 22, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Patent number: 10183447
    Abstract: The invention discloses an apparatus for aligning and supporting a first and a second length of thermoplastic tubing, preparatory to and during cutting and welding of said lengths of tubing, that includes a first holder arranged to accommodate portions of the first and second lengths of tubing in a first and a second elongated holding space respectively, a second holder arranged to accommodate portions of the first and second lengths of tubing in a third and a fourth elongated holding space respectively, and movable in a direction essentially perpendicular to the holding spaces of the first and second holders from a cutting position, a cutting means arranged between said first and second holders for cutting said lengths of tubing when the second holder is in the cutting position and an aligning means to align these lengths of tubing with each other.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: January 22, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Kishore Chengalvarayan, Manoj Ramakrishna
  • Publication number: 20190011356
    Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22?), wherein the at least one UV-transparent window (22?) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 10, 2019
    Applicant: GE Healthcare Bio-Sciences AB
    Inventor: Hanno Ehring
  • Patent number: 10155253
    Abstract: The invention discloses a method for individually assessing the cleanness of at least one of an upper (2) and a lower (3) bed support in a process column (1). The method comprises the steps of: a) providing a process column (1) comprising an upper (2) and a lower (3) bed support, a column chamber, a movable adaptor (5), an upper outlet (6) and a lower outlet (7); b) conveying liquid through one of the lower (3) and upper (2) bed supports, e.g. by moving the adaptor (5) downwards at a predetermined rate with one of the upper and lower outlets closed and the other open to force liquid through one of the lower and upper bed supports, and; c) measuring the differential pressure over the bed support through which liquid passes.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: December 18, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Lars Rosengren, Magnus Asplund, Niklas Pettersson
  • Patent number: 10151694
    Abstract: A method of evaluating an interaction parameter for the interaction between a plurality of analytes and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with the plurality of analytes, C: registering a sensor response curve for each one of the plurality of analytes, D: extracting interaction parameters from each sensor response curve, E: evaluating each sensor response curve according to one or more binding behavior criteria, F: displaying the interaction parameters in a diagram, wherein interaction parameters relating to response curves meeting a binding behavior criteria are graphically distinguishable from interaction parameters relating to response curves meeting another or no binding behavior criteria.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: December 11, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Olof Karlsson
  • Publication number: 20180346864
    Abstract: A filter holding device (1; 41; 75; 81) arranged for providing at least one filter (7; 43a, 43b; 85) inside a flexible bag (3; 71), said filter holding device comprising attaching means (19a-d, 21a-d; 79; 83) for attaching the filter holding device to an inner surface of the flexible bag such that the at least one filter held by the filter holding device is provided at a distance from the inner surface of the flexible bag.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 6, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Eric Faldt, Ralph Stankowski
  • Publication number: 20180340917
    Abstract: A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 29, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventor: Karol Lacki
  • Patent number: 10125349
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or Inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: November 13, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 10113996
    Abstract: A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: October 30, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Markus Olovsson, Karol Maciej Lacki, Mikael Johan Helmer Eugene Berg
  • Publication number: 20180304231
    Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Mattias Algotsson, Stefan D. Eriksson
  • Patent number: 10105622
    Abstract: The invention discloses a normal flow filtration cassette (1) stackable with like cassettes, said cassette comprising: at least three port conduits (2,3,4); an inlet chamber (5) in fluid communication at least with a first of said port conduits (2); an outlet chamber (6) in fluid communication at least with a second of the port conduits (3); and a filter medium (7) between said inlet chamber and said outlet chamber, wherein said at least three port conduits (2,3,4) are each in fluid communication with a corresponding inlet port (8,9,10) and are each in fluid communication also with one of a corresponding set of outlet ports (11,12,13), and wherein each of said set of inlet ports (8,9 10) is arranged to cooperate with a respective complementary outlet port of an adjacent like cassette when in a stack and said outlet ports (11,12,13) are each arranged to cooperate with a respective complementary inlet port of a further adjacent like cassette when in a stack.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: October 23, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Charles Lambalot, William Larsen
  • Patent number: 10099047
    Abstract: A separation or reaction unit (1; 1?; 81; 81?; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1?; 81; 81?; 101) comprises at last one fluid inlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: October 16, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Patent number: 10101347
    Abstract: Automated fluid handling system comprising a controller arranged to control the operation of the fluid handling system in accordance with a predefined or user-defined operation process, the fluid handling system comprising a power source input for connection to an external power source, the fluid handling system comprising a back-up power source arranged to supply back-up power to the controller, wherein the controller is arranged to monitor the power source input and in response to a detected power shortage initialize suspend mode of operation powered by the back-up power source, and during suspend mode saving information relating to status of the operation process at the time of power shortage in response to a detected power up initialize a boot procedure comprising a verification if the boot procedure is initialized following a suspend mode or not: if the boot procedure is not initialized following a suspend mode, then proceed according to normal boot procedure to enable start of a new operation proces
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: October 16, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Anoop Bhargav, Jeganathan Srinivasan, Babu Rasool Nabi
  • Patent number: 10094770
    Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22?), wherein the at least one UV-transparent window (22?) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Hanno Ehring
  • Patent number: 10094481
    Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Ekta Mahajan, Eric Faldt
  • Patent number: 10089850
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: October 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 10081135
    Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: September 25, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan
  • Patent number: RE47124
    Abstract: Automated fluid handling system comprising a housing (20) and two or more fluid handling units (26) arranged as interchangeable modular components with an external fluidics section (30) and an internal non fluidics section (32), and wherein the housing (20) comprises a liquid handling panel (22) with two or more of component positions for receiving said interchangeable modular components (26) such that the external fluidics section (30) is separated from the non fluidics section (32) by the liquid handling panel (22).
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 13, 2018
    Assignee: GE Healthcare Bio-Science AB
    Inventors: Johan Blomberg, Mats Lundkvist