Patents Assigned to Genentech
  • Process for Concentration of Antibodies and Therapeutic Products Thereof
    Publication number: 20070237762
    Abstract: The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 11, 2007
    Applicant: GENENTECH, INC.
    Inventor: Charles Winter
  • Production of Vascular Endothelial Cell Growth Factor and DNA Encoding Same
    Publication number: 20070238642
    Abstract: DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.
    Type: Application
    Filed: September 22, 2006
    Publication date: October 11, 2007
    Applicant: Genentech, Inc.
    Inventors: Napoleone Ferrara, David Leung
  • VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTORS HAVING ANTAGONISTIC PROPERTIES, NUCLEIC ACIDS ENCODING THE SAME AND HOST CELLS COMPRISING THOSE NUCLEIC ACIDS
    Publication number: 20070238659
    Abstract: The present invention involves the preparation of vascular endothelial growth factor (VEGF) antagonist molecules comprising variant VEGF polypeptides which are capable of binding to and occupying cell surface VEGF receptors without inducing a VEGF response, thereby antagonizing the biological activity of the native VEGF protein. Specifically, the variant VEGF polypeptides of the present invention comprise modifications of at least one cysteine residue in the native VEGF sequence, thereby inhibiting the ability of the variant polypeptide to dimerize through the formation of disulfide bonds. The present invention is further directed to methods for preparing such variant VEGF antagonists and to methods, compositions and assays utilizing such variants for producing pharmaceutically active materials having therapeutic and pharmacologic properties that differ from the native VEGF protein.
    Type: Application
    Filed: September 28, 2006
    Publication date: October 11, 2007
    Applicant: Genentech, Inc.
    Inventors: Bruce Keyt, Francis Nguyen, Napoleone Ferrara
  • Method for using BOC/CDO to Modulate Hedgehog Signaling
    Publication number: 20070237774
    Abstract: The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.
    Type: Application
    Filed: January 22, 2007
    Publication date: October 11, 2007
    Applicant: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Hua Tian
  • PRO1083 polypeptides
    Patent number: 7279553
    Abstract: The present invention is directed to novel seven transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: October 9, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood, Luc Desnoyers
  • Analytical method
    Patent number: 7279287
    Abstract: The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: October 9, 2007
    Assignee: Genentech, Inc.
    Inventor: Peter Ralph
  • Pro1782 polypeptides
    Patent number: 7279552
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: October 9, 2007
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Steven Sherwood, Victoria Smith, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Pro1556 Polypeptide
    Patent number: 7279551
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: October 9, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMORS OF GLIAL ORIGIN
    Publication number: 20070231323
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumors of glial origin in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 19, 2007
    Publication date: October 4, 2007
    Applicant: Genentech, Inc.
    Inventor: Heidi Phillips
  • Methods of using death receptor ligands and CD20 antibodies
    Publication number: 20070231324
    Abstract: Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and CD20 antibodies to treat conditions such as cancer and immune related diseases are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with CD20 antibodies.
    Type: Application
    Filed: October 3, 2006
    Publication date: October 4, 2007
    Applicant: Genentech, Inc.
    Inventor: Avi Ashkenazi
  • Antibodies to a polypeptide encoded by a nucleic acid under-expressed in stomach and lung tumor
    Patent number: 7276586
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: October 2, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • PRO1866 polypeptides
    Patent number: 7276577
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: October 2, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO4334 polypeptides
    Patent number: 7276578
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: October 2, 2007
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20070224201
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 29, 2003
    Publication date: September 27, 2007
    Applicant: Genentech, Inc.
    Inventors: Thomas Wu, Zemin Zhang, Yan Zhou
  • System for Antibody Expression and Assembly
    Publication number: 20070224664
    Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: January 25, 2007
    Publication date: September 27, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Dana Anderson
  • Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same
    Publication number: 20070224185
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 27, 2007
    Applicant: Genentech, Inc.
    Inventors: Kevin Baker, Maureen Beresini, Laura DeForge, Luc Desnoyers, Ellen Filvaroff, Wei-Qiang Gao, Mary Gerritsen, Audrey Goddard, Paul Godowski, Austin Gurney, Steven Sherwood, Victoria Smith, Timothy Stewart, Daniel Tumas, Colin Watanabe, William Wood, Zemin Zhang
  • Benzofuran inhibitors of factor VIIa
    Patent number: 7273886
    Abstract: Compounds of Formula I are useful for inhibiting serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein and have improved pharmacokinetic properties. These compounds may be used in methods of preventing and/or treating clotting disorders.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: September 25, 2007
    Assignee: Genentech, Inc.
    Inventors: Alan G. Olivero, Daniel P. Sutherlin
  • Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
    Patent number: 7273726
    Abstract: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: September 25, 2007
    Assignee: Genentech, Inc.
    Inventors: Sherman Fong, Audrey Goddard, Austin L. Gurney, William I. Wood
  • Antibody to PRO1779 polypeptides
    Patent number: 7273926
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: September 25, 2007
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Methods of treating lupus using CD4 antibodies
    Publication number: 20070218062
    Abstract: Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and/or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 20, 2007
    Applicant: Genentech, Inc.
    Inventor: Bryan Irving