Abstract: A solid electrolyte comprising a compound of the formula Ay(MS4)z(PS4)4-zX3 having an ionic conductivity of from 10?7 to 10?4 S/cm at room temperature, and methods of making a solid electrolyte.

Abstract: The disclosed technology includes an infrared-emitting quantum dot comprising a core comprising a first semiconductor material, a shell comprising a second semiconductor material, and a gradient interface between the core and the shell. The disclosed technology also includes methods of manufacturing the same.

Abstract: This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.

Abstract: A hydrodynamic barrier device including: a plurality of outlets disposed on a surface; a plurality of inlets dispersed among the plurality of outlets and disposed on the surface; and at least one pump in fluid communication with the plurality of outlets and the plurality of inlets, the at least one pump configured to simultaneously pump an operating fluid out of the plurality of outlets and pull the operating fluid back through the plurality of inlets to create a hydrodynamic barrier on the surface.

Abstract: A cooling system for an electric motor that includes a stator having a plurality of slot windings and a rotor, coaxial with the stator, having a plurality of magnets, includes a coolant inlet to the motor and a coolant outlet from the motor. A coolant pathway is in fluid communication with the inlet and the outlet. Heat is transferable from the slot windings to the coolant pathway. A coolant flows through the coolant pathway and is in a liquid phase as it enters the coolant inlet, changing into a gaseous phase as heat is transferred to the coolant from the slot windings. A cooling loop is in fluid communication with the coolant inlet and the coolant outlet. The cooling loop cools the coolant so that substantially all of the coolant is in the liquid phase when it enters the coolant inlet.

Abstract: The present disclosure provides methods for administering formulations to the suprachoroidal space of the eye to achieve targeted drug delivery to a desired site of action within the eye. The methods include using a pushing formulation that includes a material such as a gel that expands due to physiochemical cues; or using an electric field to affect the movement of a formulation within the suprachoroidal space; or a combination of a pushing formulation with an electric field.

Abstract: Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.

Abstract: The disclosure relates to novel compounds and methods of use of the compounds to maintain the G?i2 protein in its inactive GDP-bound state. The disclosure describes the knockdown or inhibition of G?i2 negatively regulated migration of breast and ovarian cancer cell lines. The novel compounds inhibit the migratory behavior of PC3, DU145 and E006AA prostate cancer cell lines. Specifically, the novel compounds block the activation of G?i2 in oxytocin-stimulated prostate cancer PC3 cells and inhibits the migratory capability of DU145 cells overexpressing constitutively active form of G?i2, under basal and EGF-stimulated conditions.

Abstract: A dual-drive power amplifier (PA) where the PA core includes a differential pair of transistors M1 and M2 that are driven by a coupling network having two transmission-line couplers, where a first transmission line section of a coupler is configured to transmit an input signal Vin through to drive a gate of the opposite transistor, while the second transmission line section is grounded at one end and coupled with the first transmission line section such that a coupled portion ?Vin of the input signal Vin drives the source terminal of a corresponding transistor. The arrangement of the coupling network allows the source terminals to be driven below ground potential. Embodiments disclosed here further provide an input matching network, a driver, an inter-stage matching network, and an output network for practical implementation of the PA core.

Abstract: A system for providing direct silicon microfluidic cooling for electronics includes a cooling block with a first side and a second side. A plurality of micro-pin fins are disposed on the first side of the cooling block. A thermal interface material layer contacts a second side of the cooling block while a manifold is coupled to the cooling block and faces the micro-pin fins. The manifold has an inlet port and an outlet port for supporting cooling fluid flow between the inlet port and outlet port. The cooling fluid from the inlet port and outlet port also flows between the micro-pin fins for removing heat from the micro-pin fins absorbed by the cooling block from the thermal interface layer. The inlet port and outlet port each further comprise a cooling block port having a first geometry that corresponds with edges of a second geometry formed by the micro-pin fins.

Abstract: In a method of depositing a fibroin structure, a fibroin ink is generated. The fibroin ink is aerosol jet printed onto a substrate. To prepare the ink, a plurality of biologically-generated silk cocoons are each cut into at least two pieces of raw silk and are degummed to remove sericin, leaving fibroin fibers. The fibroin fibers are dissolved into a lithium bromide solution. The salt is removed by placing the fibroin/salt solution in a dialysis membrane tube and submerging it in deionized water. The fibroin solution is centrifuged to remove impurities therefrom, leaving fibroin ink. The fibroin ink is atomized into a fibroin ink aerosol, which is directed to a print nozzle. A focusing gas sheath is directed around the print nozzle to deposit fibroin onto a surface.

Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.

Abstract: Described are composites having at least one layer, the at least one layer including an alloy of Al and at least another component or at least one layer including a first and second pluralities of particles. The first plurality of particles may be selected from at least one of Al particles and Al alloy particles. The second plurality of particles may be selected from at least one of metal particles and non-metal particles, wherein the metal particles are selected from at least one of zinc, silicon, bismuth, copper, germanium, indium, antimony, tin, magnesium, or combinations thereof, and the non-metal particles are selected from at least one of carbon, lithium titanium oxide, titania, MoO, MoS2, Co2O4, MnO2, Fe2O3, Fc3O4, FeS, CuO, or combinations thereof. The composites may be used as both current collectors and active material.

Abstract: A method of targeting antigen-presenting cells and delivering an encapsulated payload with lipid nanoparticles including a POZ-lipid conjugate. The encapsulated payload may include, but is not limited to, a nucleic acid payload such as mRNA or modified mRNA. These LNPs are not subject to accelerated blood clearance and they have a low or reduced immunogenicity profile in vivo.

Abstract: This disclosure is directed to manual devices or systems for mixing or separating components of a solution. The manual devices or systems include a body and an actuator movably coupled to the body that can be manually actuated by a user. The manual devices and systems include a coupling rotatably coupled to the body. A mounting mounts to the coupling to hold a container filled with a solution. The manual devices and systems include a transmission operatively connected to the actuator and to the coupling. The transmission transmits a manual force from the actuator to the coupling to rotate the coupling and the mounting and mix or separate components within the solution. The manual force applied to the actuator and transmitted to the coupling by the transmission is the only force actively applied by the manual device to the coupling to rotate the coupling.

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Abstract: Disclosed herein is a chemical sensing system, comprising: a sensor configured to adsorb an analyte; an electronic circuit to operate the sensor; and a microcontroller in communication with the sensor and the electronic circuit. The microcontroller can also be configured to provide a real-time signal indicative of a concentration of the analyte. The sensor can comprise a microelectromechanical system (MEMS) resonator and a sensing film configured to adsorb the analyte, the sensing film coating at least a portion of the sensor. The MEMS resonator can comprise a second sensor, such as an impedimetric sensor to measure at least a second property of the sensing film. The electronic circuit can process signals stemming from at least two properties of the same sensing film, such as the changes in mass and dielectric constant of the same sensing film due to adsorption of analyte.

Abstract: Disclosed herein are systems and methods that can present low-temperature recycling of rare metals from spent electrodes. An exemplary method of recycling a battery comprises: mixing, in a solution, at least an electrode material and a first solvent; reducing the electrode material in the solution to create a metallic material; and extracting the metallic material from the solution.

Abstract: The present disclosure relates to a photovoltaic (PV) device that includes a first junction constructed with a first alloy and having a bandgap between about 1.0 eV and about 1.5 eV, and a second junction constructed with a second alloy and having a bandgap between about 0.9 eV and about 1.3 eV, where the first alloy includes III-V elements, the second alloy includes III-V elements, and the PV device is configured to operate in a thermophotovoltaic system having an operating temperature between about 1500° C. and about 3000° C.

Abstract: Systems and methods for time-shifted prefetching of predicted content for wireless users. Prefetching video data can include retrieving video data and feature data and generating a video candidate set including selected videos of the related video data. The method can further include determining predicted videos using a machine learning algorithm. The predicted videos can be videos of the video candidate set that are likely to be viewed by a user at a future time. The method can further include prefetching the predicted videos by downloading the predicted videos.