Patents Assigned to Gifu University
  • Patent number: 8187188
    Abstract: A computer 12 of an image processing apparatus 11 acquires ultrasound B-mode images of consecutive frames to estimate a carotid artery wall at a carotid artery minor axis cross section included in an ultrasound B-mode image of a predetermined frame. The computer 12 also uses, as a template image, the ultrasound B-mode image, which includes the estimated carotid artery wall and surrounding tissues of the carotid artery wall and estimates the size of the diameter of the carotid artery wall so as to minimize a margin of error between a transformed template image, which is created by transforming the template image, and the acquired ultrasound B-mode image of each frame, thereby acquiring the time change of the carotid artery wall.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: May 29, 2012
    Assignee: Gifu University
    Inventors: Yasunari Yokota, Fumio Nogata, Yoko Kawamura
  • Publication number: 20110319616
    Abstract: An object is to provide a thiazole derivative produced from easily available raw materials by a simplified production process. Provided are a process for producing a novel thiazole derivative represented by the general formula (I), which is characterized by adding a strong base to a thioamide represented by the general formula (II) and reacting the mixture with a thioformamide represented by the general formula (III), and a novel thiazole derivative.
    Type: Application
    Filed: March 8, 2010
    Publication date: December 29, 2011
    Applicant: GIFU UNIVERSITY
    Inventor: Toshiaki Murai
  • Patent number: 8067631
    Abstract: To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP2 (alkenyl) and SP3 (alkyl) carbon atoms rapidly and in a high yield. Methyl iodide and an alkenyltrialkylstannane are subjected to cross coupling in an aprotic polar solvent in the presence of a palladium complex having a valence of 0, a phosphine ligand, a cuprous halide, and a carbonate and/or alkali metal fluoride.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: November 29, 2011
    Assignee: Gifu University
    Inventors: Masaaki Suzuki, Takamitsu Hosoya
  • Publication number: 20110286937
    Abstract: The present invention provides a glycolipid-containing liposome. In such a glycolipid-containing liposome, the glycolipid includes a plant ceramide portion and a sugar chain portion. The present invention also provides a method of producing a glycolipid-containing liposome. This method includes the following steps of: A) providing a glycolipid in which the glycolipid includes a plant ceramide portion and a sugar chain portion; and B) mixing the provided glycolipid with a liposome raw material and subjecting the mixture to conditions in which a liposome is formed.
    Type: Application
    Filed: February 18, 2009
    Publication date: November 24, 2011
    Applicants: GIFU UNIVERSITY, KATAYAMA CHEMICAL INDUSTRIES CO., LTD.
    Inventors: Makoto Kiso, Hideharu Ishida, Taiji Yamashita, Koichi Igarashi, Masahiko Hirai
  • Publication number: 20110263849
    Abstract: Provided is a method whereby a heteroaromatic ring aryl can be very rapidly methylated at a high yield. In an N-alkyl-2-pyrrolidinone, a heteroaromatic ring aryltrialkylstannan is cross-coupled with methyl iodide in the presence of a palladium complex, a phosphine ligand, a cuprous halide, a carbonic acid salt and/or an alkali metal fluoride to thereby rapidly methylate the heteroaromatic ring aryl. (Formula shows a case wherein the heteroaromatic ring aryl is a pyridyl group.
    Type: Application
    Filed: December 25, 2009
    Publication date: October 27, 2011
    Applicants: GIFU UNIVERSITY, RIKEN
    Inventors: Masaaki Suzuki, Hisashi Doi, Hiroko Koyama
  • Publication number: 20110201110
    Abstract: The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth extracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks.
    Type: Application
    Filed: October 2, 2008
    Publication date: August 18, 2011
    Applicants: GIFU UNIVERSITY, KYOTO UNIVERSITY
    Inventors: Kenichi Tezuka, Toshiyuki Shibata, Takahiro Kunisada, Naritaka Tamaoki, Tomoko Takeda, Shinya Yamanaka, Kazutoshi Takahashi
  • Publication number: 20110172433
    Abstract: [Technical Problem] To provide a novel imino derivative capable of being an insecticide compound having excellent characteristics such as sustained effects and broad spectrum. [Solution to Problem] To provide an imino derivative represented by Formula (1). wherein “Ar” denotes a heterocyclic group which may have a substituent on the ring; “X” denotes a sulfur atom or CH2, NR; “R” denotes a hydrogen atom or an alkyl group; “Y” is selected from COR1 or CONR3R4, CONHCOR5, CO2R9; and each of “R1”, “R3”, “R4”, “R5”, and “R9” denotes a hydrogen atom or a certain substituent.
    Type: Application
    Filed: July 1, 2009
    Publication date: July 14, 2011
    Applicants: MEIJI SEIKA KAISHA, LTD., GIFU UNIVERSITY
    Inventors: Shinzo Kagabu, Masaru Mori, Satoru Kumazawa
  • Patent number: 7968733
    Abstract: To provide a pyrrolidine analogue having an inhibitory activity on the induction of allodynia, a method for producing the pyrrolidine analogue, and an agent for preventing a neurogenic pain. A pyrrolidine analogue which is a compound represented by the general formula (I) [wherein HOOC-? represents an aromatic substituent having at least one carboxy group attached to the benzene ring] or a salt or ester of the compound. The compound has a potent inhibitory effect on the induction of allodynia.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: June 28, 2011
    Assignees: Gifu University, Kansai Medical University, Osaka Medical College
    Inventors: Masaaki Suzuki, Kyouji Furuta, Toshiaki Minami, Seiji Ito
  • Publication number: 20110112402
    Abstract: A computer 12 of an image processing apparatus 11 acquires ultrasound B-mode images of consecutive frames to estimate a carotid artery wall at a carotid artery minor axis cross section included in an ultrasound B-mode image of a predetermined frame. The computer 12 also uses, as a template image, the ultrasound B-mode image, which includes the estimated carotid artery wall and surrounding tissues of the carotid artery wall and estimates the size of the diameter of the carotid artery wall so as to minimize a margin of error between a transformed template image, which is created by transforming the template image, and the acquired ultrasound B-mode image of each frame, thereby acquiring the time change of the carotid artery wall.
    Type: Application
    Filed: March 24, 2008
    Publication date: May 12, 2011
    Applicant: GIFU UNIVERSITY
    Inventors: Yasunari Yokota, Fumio Nogata, Yoko Kawamura
  • Publication number: 20110105901
    Abstract: A computer 12 of an image processing apparatus 11 acquires a moving image including a minor axis cross section of a carotid artery and a cross section of surrounding tissues around the carotid artery and estimates, from images of two temporally different frames of the acquired moving image, an optical flow of each point included in an area corresponding to a carotid artery wall and an optical flow of each point included in an area corresponding to the surrounding tissues. Based on the estimated optical flow of each point, the computer 12 calculates an amount of displacement of the carotid artery and the surrounding tissues with respect to a radial direction of the carotid artery depending on a change in internal pressure of the carotid artery.
    Type: Application
    Filed: March 24, 2008
    Publication date: May 5, 2011
    Applicant: GIFU UNIVERSITY
    Inventors: Yasunari Yokota, Rie Taniguchi, Yoko Kawamura, Fumio Nogata
  • Publication number: 20110040181
    Abstract: An image processing device acquires an ultrasound B-mode image sequence and creates an evaluation function of a mode of the longitudinal sectional shape of the carotid artery rendered in a frame following the frame that has already been modeled, thereby optimizing the evaluation function. The image processing device estimates and models the position and shape of the longitudinal sectional shape of the carotid artery for the following frame based on the optimization result, and performs the same for the subsequent frames. The image processing device outputs a variation of the carotid artery diameter in response to heartbeats based on the modeling result.
    Type: Application
    Filed: March 17, 2008
    Publication date: February 17, 2011
    Applicant: GIFU UNIVERSITY
    Inventors: Yasunari Yokota, Fumio Nogata, Yoko Kawamura
  • Publication number: 20100296715
    Abstract: The present teaching aims to detect a lesion in tissue at a very early stage.
    Type: Application
    Filed: September 25, 2008
    Publication date: November 25, 2010
    Applicant: GIFU UNIVERSITY
    Inventors: Yasutomi Kinosada, Shigeru Matsushima, Seiichi Era, Shinji Osada
  • Publication number: 20100249477
    Abstract: It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate; a kit for preparing a PET tracer to be used in the same, and a method of producing a PET tracer using the same. In an aprotic polar solvent, methyl iodide or X—CH2F (wherein X is a functional group which can be easily released as an anion), an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.
    Type: Application
    Filed: August 24, 2007
    Publication date: September 30, 2010
    Applicants: GIFU UNIVERSITY, RIKEN, HAMAMATSU PHOTONICS K.K.
    Inventors: Masaaki Suzuki, Hisashi Doi, Hideo Tsukada
  • Publication number: 20100121192
    Abstract: The blood vessel imaging system includes a carriage for moving in a row direction an ultrasonic probe having a plurality of ultrasonic transducers arranged along a column direction and along the row direction. A computer repeats intermittent movement control for the carriage in shorter distance than a row pitch of the ultrasonic transducers along the row direction for each of a plurality of predetermined periods. Three-dimensional image processing or four-dimensional image processing is performed on the basis of a two-dimensional image and position information, the two-dimensional image being generated by making original image information, which is obtained by the ultrasonic transducers, two-dimensional in an ultrasonograph. The computer generates the images of a maximum diameter, a minimum diameter, and the difference between the maximum diameter and the minimum diameter for each measurement site in a carotid artery on the basis of the image processing result.
    Type: Application
    Filed: March 21, 2008
    Publication date: May 13, 2010
    Applicant: GIFU UNIVERSITY
    Inventors: Fumio Nogata, Yasunari Yokota, Yoko Kawamura
  • Patent number: 7690258
    Abstract: An impact elastic wave test is conducted to measure propagating waves in a pipe to be examined, a frequency spectrum of the propagating waves is analyzed, and at least a spectral area value in a first frequency region and a spectral area value in a second frequency region of the frequency spectrum are evaluated, thereby determining a type of a deteriorated state of the buried pipe.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: April 6, 2010
    Assignees: Sekisui Chemical Co., Ltd., Gifu University
    Inventors: Takushi Minagi, Hiroshi Iida, Masanori Asano, Toshiro Kamada
  • Publication number: 20100075305
    Abstract: Disclosed is a method for detecting the species of a bacterium in a simple manner. Specifically disclosed is a method for detecting the species of a bacterium, which can detect at least one bacterial species selected from Staphylococcus species, Streptococcus species, Klebsiella species, Escherichia species, Mycobacterium species, Legionella species, Vibrio species, Bacillus species, Neisseria species, Campylobacter species, Chlamydia species, Chlamydophila species, Mycoplasma species, Listeria species, Salmonella species and Yersinia species, and which comprises the steps of: a) contacting a sample suspected to contain a nucleic acid derived from the bacterial species; and b) detecting the presence or absence of the hybridization between the nucleic acid molecule and the nucleic acid contained in the sample.
    Type: Application
    Filed: September 26, 2007
    Publication date: March 25, 2010
    Applicants: GIFU UNIVERSITY, AMR, INC.
    Inventors: Takayuki Ezaki, Kiyofumi Ohkusu, Shigeru Yoshida
  • Publication number: 20090306407
    Abstract: [Problems] To provide a pyrrolidine analogue having an inhibitory activity on the induction of allodynia, a method for producing the pyrrolidine analogue, and an agent for preventing a neurogenic pain. [Means for Solving the Problems] A pyrrolidine analogue which is a compound represented by the general formula (I) [wherein HOOC-? represents an aromatic substituent having at least one carboxy group attached to the benzene ring] or a salt or ester of the compound. The compound has a potent inhibitory effect on the induction of allodynia.
    Type: Application
    Filed: May 23, 2007
    Publication date: December 10, 2009
    Applicants: Gifu University, Kansai Medical University, Osaka Medical College
    Inventors: Masaaki Suzuki, Kyouji Furuta, Toshiaki Minami, Seiji Ito
  • Publication number: 20090238759
    Abstract: To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP2 (alkenyl) and SP3 (alkyl) carbon atoms rapidly and in a high yield. Methyl iodide and an alkenyltrialkylstannane are subjected to cross coupling in an aprotic polar solvent in the presence of a palladium complex having a valence of 0, a phosphine ligand, a cuprous halide, and a carbonate and/or alkali metal fluoride.
    Type: Application
    Filed: October 6, 2006
    Publication date: September 24, 2009
    Applicant: GIFU UNIVERSITY
    Inventors: Masaaki Suzuki, Takamitsu Hosoya
  • Publication number: 20090202190
    Abstract: When light is made incident to an optical waveguide path 14 formed through a main body 12 composed of silver (Ag) that is a plasmon active medium, surface plasmon is generated on a definition face 55 of the optical waveguide path 14 (including a fine aperture 16). Thus, the intensity of the light propagating in the optical waveguide path 14 is strengthened as the light propagates toward the fine aperture 16. In addition, a distal end 51 of a first protrusive piece 13a is more protrusive as compared with a distal end 52 of a second protrusive piece 13b. Thus, in a distal end part of a projection 13, the light is focused in the vicinity of the first protrusive piece 13a based on an intensity distribution of an electric field at the distal end part. Thus, the light having seeped out from the fine aperture 16 is restricted from spreading in a polarizing direction.
    Type: Application
    Filed: June 10, 2005
    Publication date: August 13, 2009
    Applicant: GIFU UNIVERSITY
    Inventors: Kazuo Tanaka, Masahiro Tanaka
  • Patent number: 7427818
    Abstract: A relaxor ferroelectric solid solution single crystal is capable of making transitions, at temperatures below the Curie temperature, between a first state which has a high permittivity and blocks optical transmission and a second state which has a low permittivity and allows optical transmission. The relaxor ferroelectric solid solution single crystal undergoes a transition to the second state if an electric field above a threshold is applied thereto in the first state. The relaxor ferroelectric solid solution single crystal undergoes a transition to the first state if heated to or above the Curie temperature in the second state.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: September 23, 2008
    Assignee: Gifu University
    Inventors: Naohiko Yasuda, Hidehiro Ohwa, Makoto Iwata