Abstract: The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.

Abstract: A communication system provides multimedia communications within and between armored ground combat vehicles (GCVs). The system includes client computers within the armored GCVs providing distributed and interconnected multimedia communications among the client computers. The multimedia communication may include a one-to-one communication, a text communication to a group, an audio communication to a group, or a video communication to a group. Logic providing the distributed and interconnected multimedia communications is not located at a single client computer. The client computers display graphical user interfaces (GUIs) enabling soldiers to select parameters of the communication system with some GUIs providing presence discovery among the armored GCVs. One of the plurality of client computers acts as an origination station and other client computers may be configured as receiving communication station(s).

Abstract: The present disclosure describes methods and systems for predicting if a subject has an increased risk of having or developing venous thromboembolism, including prior to the detection of symptoms thereof and/or prior to onset of any detectable symptoms thereof. The present disclosure also describes a method of generating a model for predicting venous thromboembolism.

Abstract: A footwear system can employ a brake and/or a clutch, such as a one-way clutch, to convert human motion into usable electricity. The brake and one-way clutch can be used together, such as on opposite ends of a spring. During a storage phase, the brake can be engaged and the one-way clutch disengaged so the spring stores an energy. After the storage phase, the brake can be removed to initiate the release phase since the brake is not stopping the spring, but the one-way clutch allows the stored energy to be released.

Abstract: A method of estimating a body temperature of an individual based on physiological data including a heart rate received from at least one sensor 510 and received environmental data. The physiological data and the environmental data are inputted into a model present on a processor 520. The model generates an estimated body temperature and an estimated physiological condition based on the inputs. The processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.

Abstract: Various embodiments associated with a segmented magnetic core are described. The segmented magnetic core can be made up of multiple singular structures so as to allow an individual singular structure to be removed with ease and without disturbing another magnetic core. This modular core design allows for a significant reduction in motor housing weight due to compatibility of the design with lightweight materials and the potential absence of extensive housing when so designed. This modular core design can be incorporated into a motor or a generator and this modular core design can be accomplished, in one example, by way of stacking and/or interlocking employing low cost assembly. In one example, a motor or a generator uses sensors to detect an operational failure in a magnetic core, notifying a user early of the failure.

Abstract: An embodiment of the invention provides a method of estimating a body temperature of an individual where physiological data is received from at least one sensor 510. Environmental data is received and the physiological data and the environmental data are input into a model. The model generates an estimated body temperature and an estimated physiological condition based on the physiological data and the environmental data. A processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.

Abstract: Various embodiments are described that relate to charging a battery set. The battery set can comprise a first battery and a second battery. The batteries can be alternately charged so they are balanced. In one example, when the first battery is charged, then the second battery is not charged and vice versa. The alternation of charging can be managed based on different criteria, such as timing or charge level.

Abstract: A pre-fabricated tourniquet that is easy to apply, that ensures consistent and even circumferential pressure, that is lightweight, that provides standard life saving operation, and that can be utilized in any setting or situation, and related methods are provided. Mechanically constricting tourniquet apparatus and related methods are provided that are comprised of a tourniquet body, a carriage, a torsion bar, a receiver, and a slider. The tourniquet is long enough to encircle a human limb, for example, an arm or leg. The tourniquet apparatus includes several features for preventing or otherwise limiting harm to users and/or damage to the tourniquet apparatus itself.

Abstract: Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

Abstract: The present disclosure is directed to isolated recombinant antibodies, or antigen-binding fragments thereof, that bind to fentanyl or fentanyl analogs. The novel antibodies or antigen-binding fragments thereof can be used to detect, diagnose, treat, and/or prevent opioid use disorder.

Abstract: One example embodiment is an armored vehicle door quick-release mechanism includes a handle, a slide lock latch, and an actuator mechanism. The handle is coupled to the slide lock latch. The movement of the handle in a first direction causes the slide lock latch to move in a first direction to a first position so that the slide lock latch is adapted to attach the vehicle door to the actuator mechanism adapted to open and close the vehicle door. A movement of the handle in a second direction causes that slide lock latch to move in a second direction to a second position to detach the vehicle door from the actuator mechanism.

Abstract: A portion of ankle movement can be harnessed into stored energy that can be released for various purposes, such as to assist in movement or to charge a battery. This harnessing can be achieved in various manners. In one example manner, an offset pulley component can transfer ankle movement to a generator in a shoe insole. In another example manner, a slider can cause a brace arch to match an ankle arch such that the movement is appropriately harnessed.

Abstract: Various embodiments are described that relate an electrical current connector. The electrical current connector can be configured to provide electrical current when pressure is applied to a prong set. This pressure can cause a contact to engage with a connector. This can complete a circuit that allows the electrical current to flow. The connector can be coupled to a cable that can be configured to transfer data along with the electrical current. The cable can have an inner portion that transfers the data while an outer portion that surrounds the inner portion transfers the current.

Abstract: A portable filtration system is described. The system may comprise: a mixing portion, comprising: a pump adaptor and a contaminant regulator. The pump adaptor may comprise: an upper plate, a lower plate, and a screen. The screen may axially extend between the upper and lower plates, wherein the upper plate, the lower plate, and the screen define a channel of a mixing chamber. The contaminant regulator may comprise a through-passage coupled to the upper plate, wherein the through-passage is in fluid communication with the mixing chamber.

Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C1 (NPC1) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.

Abstract: Provided here are immunoglobulins and compositions containing one or more of said immunoglobulins reactive to a strain of Marburg virus. The immunoglobulins and compositions comprising said immunoglobulins can be used prophylactically to prevent a Marburg virus infection or to treat a patient that has been exposed to a Marburg virus in order to reduce a symptom.

Abstract: The disclosure relates to compositions, assays, methods and kits comprising one or more amino acid sequences of a filovirus protein, or a fragment thereof, which find use in the detection of a filovirus infection and/or the presence of antibodies specific for a filovirus in a biological sample.

Abstract: Disclosed herein are methods for molecularly characterizing cervical cell samples as being negative for intraepithelial lesion or malignancy (NILM), low-grade squamous intraepithelial lesion (LSIL), or high-grade squamous intraepithelial lesion (HSIL).

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines,