Patents Assigned to Governors of the University of Alberta
  • Publication number: 20160222058
    Abstract: Described herein are methods of identifying and releasing bioactive peptides from their full length proteins. The method involves (a) contacting the protein with a reducing agent, a sonication step, a high pressure processing step, a heating step, a fermentation step, or any combination thereof; and (b) contacting the protein after step (a) with a hydrolytic enzyme to produce the bioactive peptide. The bioactive peptides exhibit enhanced biological activity when compared to the parent protein. The bioactive peptides may be added to foodstuffs, a medication, or to any potable, ingestible, or edible compositions.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 4, 2016
    Applicant: The Governors of the University of Alberta
    Inventors: Jianping WU, Kaustav MAJUMDER
  • Publication number: 20160222419
    Abstract: Genetically engineered Saccharomyces cerevisiae and Yarrowia lipolytica for the production of fatty alcohols, including hexadecanol and octadecanol, are provided. The S. cerevisiae and Y. lipolytica can be genetically engineered to express or over-express a plurality of enzymes involved in fatty alcohol synthesis, such as acyl-CoA thioesterase, fatty acyl reductase, fatty acyl activating enzyme and fatty acyl synthetase, and can be further genetically engineered with a deficiency in one or more enzymes involved in fatty acid oxidation, such as fatty acyl-CoA oxidase. Methods of producing fatty alcohols, such as hexadecanol and octadecanol, by fermenting the genetically engineered S. cerevisiae and Y. lipolytica are also described.
    Type: Application
    Filed: September 18, 2014
    Publication date: August 4, 2016
    Applicant: The Governors of the University of Alberta
    Inventor: David Troy STUART
  • Patent number: 9403870
    Abstract: The invention is directed to methods for extracting phosvitin from egg yolk involving contacting the egg yolk or egg yolk protein granules with a solution having a salt concentration of about 10% to form a mixture; optionally, heating the mixture; adjusting the pH of the mixture to separate phosvitin from other proteins; recovering the phosvitin. The phosvitin extract may be dephosphorylated and hydrolyzed to produce phosvitin phosphopeptides.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: August 2, 2016
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Jianping Wu, Bo Lei, Jiandong Ren
  • Publication number: 20160215088
    Abstract: Aldehyde-free bio-based resin and composite materials include flexible or rigid thermoset resins of epoxidized oils derived from unsaturated oils which are cured with crosslinking carboxylic acids, natural food acids, anhydrides and acid anhydrides, and may be combined with different lignocellulosic fibers, forestry products or waste, with up to 100% renewable content.
    Type: Application
    Filed: November 12, 2013
    Publication date: July 28, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Tolibjon OMONOV, Jonathan CURTIS
  • Patent number: 9399653
    Abstract: Described herein are the preparation and use of novel bromo-phosphonomethylphenylalanine amino acid derivatives (BrPmp) and BrPmp-containing peptides as specific, irreversible protein tyrosine phosphatase inhibitors, which are suitable for application in peptide synthesis. These derivatives are particularly advantageous since their synthesis is both easy and scalable, and they are suitable for peptide synthesis. The BrPmp derivatives described herein can be appropriately protected to allow for solid phase peptide synthesis (SPPS) and incorporation into peptides for preparation of protein tyrosine phosphatase inhibitors and inhibitor libraries. The peptides and peptide libraries can be used to identify new protein tyrosine phosphatase specific sequences and profile protein tyrosine phosphatase activity in cell lysates, diagnostic samples and biopsy samples.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: July 26, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: Christopher Warren Cairo, Naresh Singh Tulsi, Alan Michael Downey
  • Patent number: 9400957
    Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed therefrom.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: July 26, 2016
    Assignees: National Research Council of Canada, The Governors of the University of Alberta
    Inventors: Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
  • Patent number: 9397561
    Abstract: An analog open-loop self-oscillating boost converter is provided including: an output terminal for supplying an output voltage bus; an input terminal for receiving variable input power; a varactor positioned in series with the input terminal; and an oscillating network having an inductor, a resistor and a capacitor in a parallel orientation, the oscillating network connected to a semiconductor device and the varactor.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: July 19, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: Douglas Barlage, Lhing Gem Kim Shoute
  • Publication number: 20160195525
    Abstract: The invention provides isolated, purified, recombinant receptor binding proteins Gp-6, Gp-10 and Gp-31 from mycobacterium phage L5, and methods for producing these recombinant receptor binding proteins. The invention also provides the use of recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31, as probes for the identification and diagnosis of mycobacterium infections and conditions caused by mycobacterium. Further provided by the invention are methods of targeting mycobacteria using recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31. Other methods provided by the invention include the use of recombinant receptor binding proteins, such as Gp-10, in diagnostic assays for diseases, such as Johne's disease, in animals, including ruminants.
    Type: Application
    Filed: August 1, 2014
    Publication date: July 7, 2016
    Applicant: The Governors of the University of Alberta
    Inventors: Stephane Evoy, Denis Arutyunov, Upasana Singh, Christine Szymanski
  • Publication number: 20160193582
    Abstract: The present application is directed to a porous support for parallel organic synthesis comprising: a solvophilic area for spotting an organic solvent comprising a reagent for synthesizing an organic compound, and a solvophobic area that repels the organic solvent. Methods of synthesizing the support and compounds thereon are also provided.
    Type: Application
    Filed: July 18, 2014
    Publication date: July 7, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Ratmir Derda, Frederique Deiss
  • Patent number: 9376627
    Abstract: Apparatus and method for processing ore, the method comprising obtaining a reflectance spectra of an ore froth using a camera, applying a calculation using at least a wavelet decomposition to the reflectance spectra and generating a value representative of the reflectance spectra of the ore froth, classifying the quality of the ore froth using the value, and using the classification of the quality of the ore froth in froth processing.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: June 28, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: Benoit Rivard, Michael George Lipsett, Jilu Feng
  • Publication number: 20160175829
    Abstract: The present application provides a composite material and system for use in a heterogeneous flow reactor, which can include: a catalytic polymeric framework comprising catalyst-containing monomeric units each separated by at least one non-catalyst-containing monomeric unit; and a solid support material, wherein the catalytic polymeric framework is covalently or non-covalently immobilized on or in the support material. Each catalyst-containing monomeric subunit in the polymeric framework comprises a transition metal bound to a catalyst ligand. Also provided are methods of manufacture and use of the catalyst system and composite material.
    Type: Application
    Filed: August 4, 2014
    Publication date: June 23, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Steven H. BERGENS, Suneth KALAPUGAMA, Prabin NEPAL, Elizabeth MCGINITIE
  • Patent number: 9370550
    Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy. Also provided in the disclosure are vector constructs for generating mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides poxviruses comprising a functionally inactivated R2 gene.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: June 21, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: David H. Evans, Don B. Gammon
  • Publication number: 20160160048
    Abstract: The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer. The crosslinking reagents may include epoxies. The polymer may be further processed to form a thermoset plastic. The polymer may be used as an adhesive, or in the preparation of a natural fiber composite material.
    Type: Application
    Filed: July 22, 2015
    Publication date: June 9, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: David Curtis BRESSLER, Phillip CHOI
  • Patent number: 9315563
    Abstract: Described herein are methods of identifying and releasing bioactive peptides from ovotransferrin The method involves (a) contacting ovotransferrin with a reducing agent, a sonication step, a high pressure processing step, a heating step, a fermentation step, or any combination thereof, and (b) contacting the ovotransferrin after step (a) with a hydrolytic enzyme to produce bioactive peptides that exhibit angiotensin converting enzyme inhibitory activity or antioxidant activity when compared to the parent protein. The bioactive peptides may be added to foodstuffs, a medication, or to any potable, ingestible, or edible compositions.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: April 19, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: Jianping Wu, Kaustav Majumder
  • Publication number: 20160082158
    Abstract: A method of preparing a transplant site for cellular transplantation in a mammal includes the steps of inserting a foreign body comprising a biomaterial into an internal tissue; and removing the foreign body after the tissue surrounding the foreign body has undergone an inflammatory response but before significant fibrous encapsulation has occurred, leaving a neovascularized lumen suitable to receive transplanted cells or islets.
    Type: Application
    Filed: September 24, 2015
    Publication date: March 24, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: A.M. James SHAPIRO
  • Publication number: 20160067345
    Abstract: There is provided a method of detecting in a sample the presence of an anti-M and/or anti-A and/or anti-C/Y anti-body, the method comprising contacting the sample with a diagnostic conjugate provided according to the invention, comprising an oligosaccharide which comprises at least two units of 4,6-dideoxy-4-acylamido-?-pyranose and comprising at least one -(1-3)-link between adjacent 4,6-dideoxy-4-acylamido-?-pyranose units, in which the carbon at position 5 in the pyranose is linked to an R group, where R is independently selected from —CH2OH, —H or an alkyl group having at least one C atom, the oligosaccharide being covalently linked to a non-saccharide molecule or to a surface.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 10, 2016
    Applicants: THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS, THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: John MCGIVEN, David BUNDLE, Laurence HOWELLS, Julie GUIARD, Vijaya Ganesh NARAYANASWAMY
  • Publication number: 20160058892
    Abstract: Described herein are compositions having a nanoparticle that is conjugated to at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the nanoparticle by a linker, wherein the nanoparticle contains iron, and wherein the compositions are neutral or pharmaceutically acceptable salts or esters. Also described herein are methods of making these compositions. In one aspect, the nanoparticles serve as contrast agents for magnetic resonance imaging of bone metabolism. The compounds, compositions, and methods described herein can be used in a number of therapeutic applications including diagnosing or monitoring fracture and/or the progress of conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteopenia, and hypercalcemia.
    Type: Application
    Filed: April 1, 2014
    Publication date: March 3, 2016
    Applicant: The Governors of the University of Alberta
    Inventors: Michael DOSCHAK, Arash PANAHIFAR, Morteza MAHMOUDI
  • Publication number: 20160061830
    Abstract: A biosensor for detecting a microorganism in a sample includes a polymer matrix and an immobilized layer of bacteriophages on the surface of the polymer matrix, wherein interaction of the bacteriophage with the microorganism causes a detectable physicochemical change in the polymer matrix. A method of detecting a microorganism in a sample using the biosensor includes the steps of contacting the sample with the biosensor; allowing the bacteriophage to bind to the microorganism in the sample; and detecting a physicochemical change in the polymer matrix, the change being indicative of the presence of the microorganism.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 3, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Anastasia Elias, Dominic Sauvageau, Zachary Storms, Chanchan Wang, Preetam Anbukarasu, Diana Martinez-Tobon
  • Publication number: 20160059209
    Abstract: A hydrogen sulphide adsorbent is formed from an alkali metal nanotitanate having a portion of the alkali metal cations exchanged with metal cations reactive with hydrogen sulphide, and heat treated. A method for producing the adsorbent includes the steps of mixing an alkali metal nanotitanate in powder form into an aqueous metal cation solution to produce a slurry, which is subsequently dehydrated to produce a powder, which is heat treated. A low temperature method for removing hydrogen sulphide from a gaseous mixture involves exposing the gaseous mixture to the aforementioned adsorbent, at a temperature less than 250° C. The adsorbent maintains a high adsorption capacity over a range of activation temperatures and humidity conditions.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 3, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: Steven M. KUZNICKI
  • Patent number: 9274276
    Abstract: An all-dielectric metamaterial cladding is provided that can strongly confine light inside conventional low-index dielectric waveguides for use with photonic integrated circuits and nano-photonic devices. A class of metamaterials with dual electric and magnetic anisotropy along with giant birefringence can provide the ideal quasi-transverse electromagnetic mode propagation inside a glass core. A Transformed Cladding Waveguide can show an order of magnitude decreased cross-talk as compared to conventional waveguides.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: March 1, 2016
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Saman Jahani, Zubin Jacob