Patents Assigned to Governors of the University of Alberta
  • Patent number: 9120984
    Abstract: Phosphoranimide-metal catalysts and their role in hydrodesulfurization are disclosed. The catalysts comprise of first row transition metals such as nickel, cobalt and iron. The catalysts have a metal to anionic phosphoranimide ratio of 1:1 and catalyze hydrodesulfurization of a range of sulfur-containing organic compounds under lower temperature and pressure conditions than those commonly used in industrial hydrodesulfurization.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 1, 2015
    Assignee: Governors of the University of Alberta
    Inventors: Jeffrey Camacho Bunquin, Jeffrey Mark Stryker
  • Patent number: 9120741
    Abstract: Phosphoranimide-metal catalysts and their role in hydrogenation and hydrosilylation are disclosed. The catalysts comprise first row transition metals such as nickel, cobalt or iron. The catalysts have a metal to anionic phosphoranimide ratio of 1:1. This disclosure presents a process for catalytic hydrogenation and hydrosilylation of a range of unsaturated organic compounds under lower temperature and pressure conditions than conditions associated with industrial hydrogenation and hydrosilylation.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 1, 2015
    Assignee: Governors of the University of Alberta
    Inventors: Jeffrey Camacho Bunquin, Jeffrey Mark Stryker
  • Patent number: 9120845
    Abstract: The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer. The crosslinking reagents may include epoxies. The polymer may be further processed to form a thermoset plastic. The polymer may be used as an adhesive, or in the preparation of a natural fiber composite material.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: September 1, 2015
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: David Curtis Bressler, Phillip Choi
  • Publication number: 20150240289
    Abstract: The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device wherein sample administration occurs via capillary forces through a channel created by drying a hydrogel containing all components needed for a cell-free, enzymatic, nucleic-acid amplification system other than the template nucleic acid or precursor thereto, and wherein an aqueous sample is provided to the desiccated hydrogel, and the hydrogel is rehydrated, through capillary forces.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 27, 2015
    Applicant: The Governors of the University of Alberta
    Inventor: Damikka Manage
  • Publication number: 20150223679
    Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.
    Type: Application
    Filed: February 6, 2015
    Publication date: August 13, 2015
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K.S. Wong, Adam E. Cohen, Daniel R. Hochbaum
  • Patent number: 9102190
    Abstract: A nanotip, is fabricated by modifying a precursor nanotip having an apex and a shank by applying an electric field in the presence of a reactive gas to perform field-assisted etching wherein atoms are preferentially removed from the shank by chemical interaction with the reactive gas, and controlling the reactive gas pressure and/or tip voltage to vary the electric field so as to promote field evaporation of apex atoms during fabrication of the nanotip and thereby control the overall profile of the resulting nano-tip. The method permits shaping of the overall tip profile.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: August 11, 2015
    Assignees: National Research Council of Canada, The Governors of the University of Alberta
    Inventors: Jason L. Pitters, Radovan Urban, Robert A Wolcow
  • Publication number: 20150219652
    Abstract: A method of detecting a non-DNA target includes the use of a first nucleic acid motif linked to a first affinity ligand which binds specifically to the target and having a first toehold domain and a first binding domain, and a second nucleic acid motif linked to a second affinity ligand which binds specifically to the target and having a second binding domain, wherein the first and second binding domains are complementary to each other. Upon contact with the target, the first and second nucleic acid motifs bind to form a target-ligand complex. The formation of the complex causes displacement of an output nucleic acid motif. This method may be used with detectable beacons in an imaging or diagnostic method, and particularly in a point of care diagnostic method.
    Type: Application
    Filed: December 1, 2014
    Publication date: August 6, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Xiao Chun Le, Feng Li
  • Patent number: 9078429
    Abstract: A non-linear cooling cryopreservation method for improving cryopreservation protocols for cells that involves producing a simulation of cellular responses to a range of cooling parameters; determining optimal cooling parameters required to minimize cryoinjury to the cells using simulation of cellular responses and experimental results; and incorporating optimal parameters into the protocol. The simulation is based on mathematical models of cellular parameters. A non-linear cooling cryopreservation protocol for cryopreserving stem cells is also disclosed that does not require cryoprotectants.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: July 14, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Locksley Earl McGann, Janet Anne Wade Elliott, Lisa Ula Ross-Rodriguez
  • Publication number: 20150192552
    Abstract: A detector and a method for the detection of nitro-containing compounds, such as explosives, is described. Detection is by observing the quenching of the photoluminescence of functionalized silicon nanocrystals, such as amine-functionalized silicon nanocrystals, oligonucleotide-functionalized silicon nanocrystals, oligomer or monolayer alkyl-functionalized silicon nanocrystals, aromatic polymer-functionalized silicon nanocrystals and alkanoic acid-functionalized silicon nanocrystals by the nitro-containing compounds. The detector and method are non-toxic, portable, rapid and straightforward and therefore are amenable for convenient on-site detection of nitro-containing compounds.
    Type: Application
    Filed: December 23, 2014
    Publication date: July 9, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Jonathan G. C. Veinot, Mita Dasog, Christina Gonzalez, Muhammed Iqbal, Tapas Purkait, Reid Erickson
  • Patent number: 9051229
    Abstract: Phosphoranimide-metal catalysts and their role in C—O bond hydrogenolysis and hydrodeoxygenation (HDO) are disclosed. The catalysts comprise of first row transition metals such as nickel, cobalt and iron. The catalysts have a metal to anionic phosphoranimide ratio of 1:1 and catalyze C—O bond hydrogenolyses of a range of oxygen-containing organic compounds under lower temperature and pressure conditions than those commonly used in industrial hydrodeoxygenation.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: June 9, 2015
    Assignee: Governors of the University of Alberta
    Inventors: Jeffrey Camacho Bunquin, Jeffrey Mark Stryker
  • Publication number: 20150150239
    Abstract: The invention relates generally to methods and compositions for the cryopreservation and/or vitrification of tissue including articular cartilage and the preparation of said tissue for clinical or research use, including but not limited to joint replacement and the treatment and prevention of osteoarthritis.
    Type: Application
    Filed: May 20, 2014
    Publication date: June 4, 2015
    Applicant: The Governors of the University of Alberta
    Inventors: Nadr Mohamed JOMHA, Locksley Earl MCGANN, Janet Anne Wade ELLIOTT, Garson LAW, Fraser FORBES, Alireza ABAZARI TORGHABEH, Babak MAGHDOORI, Andrew WEISS
  • Patent number: 9045335
    Abstract: A hydrogen absorbing and desorbing material formed by co-deposition of magnesium with a catalyst for the kinetic absorption and desorption of hydrogen. A hydrogen absorbing and desorbing material formed of an alloy of magnesium with a catalyst for the kinetic absorption and desorption of hydrogen in which the catalyst for the kinetic absorption and desorption of hydrogen forms a dispersed amorphous or nanocrystalline phase in the magnesium. A hydrogen absorbing and desorbing material having a catalytic surface formed by a process comprising the steps of depositing a layer of tantalum on the hydrogen absorbing and desorbing material and depositing a layer of palladium on the layer of tantalum. A hydrogen absorbing and desorbing material comprises a multilayer film having at least two layers of magnesium and at least two layers of catalyst for the kinetic absorption and desorption of hydrogen, in which the multilayer film comprises alternating layers of magnesium and catalyst.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: June 2, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: David Mitlin, Beniamin Zahiri, Mohsen Danaie, Babak Shalchi Amirkhiz, XueHai Tan, Erik Luber, Christopher Harrower, Peter Kalisvaart
  • Patent number: 9040449
    Abstract: Nanoparticle catalyst compositions and methods for preparation of same are described. The nanoparticle catalysts are platinum-free and are useful in effecting selective ring-opening reactions, for example in upgrading heavy oil. The catalyst may be of monometallic composition, or may comprise an alloyed or core-shell bimetallic composition. The nanoparticles are of controlled size and shape.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: May 26, 2015
    Assignee: Governors of the University of Alberta
    Inventors: Natalia Semagina, Xing Yin, Jing Shen, Kavithaa Loganathan
  • Patent number: 9040551
    Abstract: The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: May 26, 2015
    Assignees: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, ALBERTA HEALTH SERVICES
    Inventors: Michael Weinfeld, Dennis G. Hall, Feridoun Karimi-Busheri, Gary Kenneth Freschauf, Todd Randall Mereniuk
  • Publication number: 20150136651
    Abstract: A method for desorption of bitumen from clay particles. Also a method for the desorption of asphaltenes from clay particles and a method for the desorption of bituminous fractions from mature fine tails (MFT). The method for desorption of bitumen from clay particles involves interacting, in a suitable organic solvent, a clay-bitumen composite with a compound capable of stabilizing the bitumen in the organic solvent and adsorbing to clay particles such that the compound replaces the bitumen in the clay-bitumen composite. A substantial amount of the compound that is capable of stabilizing the bitumen in the organic solvent is recovered with the clay particles, while the bitumen is released. Similarly, the method for desorption of asphaltenes from clay particles also involves interacting a clay-asphaltene composite with a compound capable of stabilizing the asphaltenes in an organic solvent, recovering the compound with the clay particles, and releasing the asphaltenes into solution.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 21, 2015
    Applicant: GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Christian DETELLIER, Sadok LATAIEF, Jonathan FAFARD, Gustave Kenne DEDZO
  • Patent number: 9023812
    Abstract: Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine stretch in the protein huntingtin (Htt). HD neurons are dysfunctional at multiple levels and have increased susceptibility to stress and apoptotic stimuli. As described therein there is provided compound(s), composition(s), methods and/or kits for the treatment and/or diagnosis of Huntington's disease.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: May 5, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Simonetta Sipione, Vittorio Maglione
  • Patent number: 9024297
    Abstract: Two- and three-terminal molecular electronic devices with ballistic electron transport are described. For example, a two-terminal molecular electronic device includes a conductor 1 layer/molecule 1 layer/conductor2 layer junction, wherein the total thickness of the molecule 1 layer and the conductor2 layer is less than or approximately equal to the mean free path of a charge carrier traveling in the two layers, and wherein ballistic transport can occur for some fraction of a plurality of charge carriers in the two layers.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 5, 2015
    Assignees: The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Richard L. McCreery, Adam Johan Bergren
  • Publication number: 20150118263
    Abstract: The present application relates to glycoengineered outer membrane vesicles obtained from recombinant, gram-negaetive bacteria comprising hetereologous DNA encoding an enzyme or enzymes that produce a heterologous glycan that replaces all or a portion of the naturally-occurring O antigen in the lipopolysaccharides of the bacteria. Also provided by the present application are immunogenic compositions and vaccines prepared from the glycoengineered outer membrane vesicles expressing the heterologous glycans at their surface.
    Type: Application
    Filed: April 26, 2013
    Publication date: April 30, 2015
    Applicant: The Governors of the University of Alberta
    Inventors: Mario Feldman, Nancy Price, Fatima Garcia-Quintanilla, Maria Veronica Ielmini
  • Patent number: 9000198
    Abstract: Phosphoranimide-metal catalysts are disclosed. The catalysts comprise first row transition metals such as nickel, cobalt or iron. The hydrocarbon-soluble catalysts have a metal to anionic phosphoranimide ratio of 1:1, and have no inactive bulk phase and no dative ancillary ligands. The electronic state of the clusters can be adjusted to optimize catalytic activity for a range of commercially important reductive transformations, including hydrodesulfurization. A method of synthesis of these catalysts by anionic metathesis of a halide substituted precursor followed by oxidation is also disclosed.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: April 7, 2015
    Assignee: Governors of the University of Alberta
    Inventors: Houston J. S. Brown, Jeffrey Mark Stryker, Dominque M. Hebert
  • Patent number: 8993270
    Abstract: The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: March 31, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Alexey Atrazhev, Jason Acker