Patents Assigned to Guangzhou Henovcom Bioscience Co., Ltd.
  • Patent number: 10919856
    Abstract: A cyclohexene compound and use thereof, which relates to the technical field of pharmaceutical chemistry is provided. The cyclohexene compound is the cyclohexene compound having a structural formula I or a pharmaceutically acceptable salt, an ester group prodrug or a stereoisomer thereof. It is verified by activity assay for influenza NA that the cyclohexene compound has a great inhibiting activity against both wild-typed and drug-resistant influenza viruses, and the inhibiting activity IC50 of some compounds against wild-typed and drug-resistant influenza viruses is lower than 5 nM, showing significant inhibiting effect on influenza viruses. This shows that the cyclohexene compound or a pharmaceutically acceptable salt or a stereoisomer thereof has superior application prospect on preparing anti-influenza drugs, thereby providing a new drug choice for treating influenza clinically.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: February 16, 2021
    Assignee: GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD.
    Inventors: Jiancun Zhang, Kun Wang, Yan Liu, Deyao Li
  • Publication number: 20180303810
    Abstract: Provided are a nimodipine water-soluble derivative, and a preparation method and a use thereof, belonging to the field of pharmaceutical chemistry. The nimodipine water-soluble derivative has the structural feature of general formula I and has a relatively high water solubility, and can be converted into nimodipine by an internal enzyme in blood or in the body, so that the nimodipine water-soluble derivative can be used as a nimodipine prodrug and a calcium ion antagonist for treating cardiovascular and cerebrovascular diseases.
    Type: Application
    Filed: July 29, 2016
    Publication date: October 25, 2018
    Applicant: Guangzhou Henovcom Bioscience Co., Ltd.
    Inventors: Jiancun Zhang, Deyao Li, Kun Wang, Yan Liu, Yuanchao Zhang