Abstract: Disclosed are compositions and methods for targeted treatment of glioblastoma multiforme (GBM). In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill Glioblastoma Stem Cells (GSCs). Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with Glioblastoma Stem Cells (GSCs) that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
Type:
Grant
Filed:
July 12, 2022
Date of Patent:
April 16, 2024
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: Disclosed are compositions and methods for targeted treatment of CLEC12A-expressing cancers. In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill CLEC12A-expressing cancers. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a CLEC12A-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs. Also disclosed are multivalent antibodies are disclosed that are able to engage T-cells to destroy CLEC12A-expressing malignant cells.
Type:
Grant
Filed:
January 8, 2019
Date of Patent:
April 9, 2024
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: Disclosed are replication-enhanced oncolytic adenoviruses. These oncolytic adenoviruses have tumor-specific replication capable of enhanced tumor oncolysis and enhanced therapeutic transgene expression. Also disclosed are methods comprising administering a replication-enhanced oncolytic adenovirus for patients suffering from a cancer.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
April 9, 2024
Assignees:
MEMGEN, INC., H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.
Type:
Grant
Filed:
March 18, 2019
Date of Patent:
April 2, 2024
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: Disclosed are methods for treating a cancer and/or enhancing immune responses to infiltration of tumors comprising administering to a subject a fucose. Also disclosed herein are methods of detecting the presence of a sugar-modified protein (i.e., a glycosylated protein).
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
February 27, 2024
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: Disclosed are inhibitors for the ?-catenin/BCL9 interaction. The inhibitors are selective for ?-catenin/BCL9 over ?-catenin/cadhenin interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.
Type:
Grant
Filed:
December 30, 2022
Date of Patent:
February 20, 2024
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: The accuracy charged-particle beam trajectories used for radiation therapy in patients is improved by providing feedback on the beam location within a patient's body or a quality assurance phantom. Particle beams impinge on a patient or phantom in an arrangement designed to deliver radiation dose to a tumor, while avoiding as much normal tissue as can be achieved. By placing fiducial markers in the tumor or phantom that contain specific atomic constituents, a detection signal consisting of atomic fluorescence is produced by the particle beam. An algorithm can combine the detected fluorescence signal with the known location of the fiducial markers to determine the location of the particle beam in the patient or phantom.
Type:
Grant
Filed:
January 13, 2021
Date of Patent:
January 23, 2024
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the threaded outer sleeve relative to the threaded distal tip allows compression or distraction to modify the gap between the vertebral bodies. The screws are passed from the inferior to superior vertebra or superior to inferior, for example, through a trans-pedicular route to avoid neurological compromise. At the same time, the path of screw insertion is oriented to reach superior or inferior vertebra. An intervertebral cage of the system is configured for lateral expansion from a nearly straight configuration to form a large footprint in the disc space. The screws and cage may be combined for improved fixation with minimal invasiveness.
Type:
Grant
Filed:
June 18, 2020
Date of Patent:
December 26, 2023
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
Inventors:
Frank D. Vrionis, Kamran Aghayev, Sabrina A. Gonzalez Blohm, James J. Doulgeris
Abstract: Disclosed are histone deacetylase (HDAC) inhibitors, or combinations comprising an HDAC inhibitor and a Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of chronic lymphocytic leukemia in a subject in need thereof. Also provided herein are methods for treating chronic lymphocytic leukemia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a BTK inhibitor. Other related methods are disclosed.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
November 14, 2023
Assignees:
ACETYLON PHARMACEUTICALS, INC., H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Simon S. Jones, Steven N. Quayle, Eva Sahakian, Javier Pinilla Ibarz
Abstract: Disclosed are compositions and methods for treating autoimmune diseases such as lupus, including immune cells expressing at least a chimeric antigen receptor (CAR) polypeptides that binds CD83 and uses thereof for suppressing and/or killing autoreactive cells in a subject having an autoimmune disease.
Type:
Application
Filed:
August 13, 2021
Publication date:
October 12, 2023
Applicants:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC., REGENTS OF THE UNIVERSITY OF MINNESOTA
Abstract: The present application relates to high flow rate isolated regional treatment of cancer and proliferative disorders and conditions. For example, provided are methods, systems and devices for treating a cancer in a region of a subject using high flow rate isolated infusion.
Type:
Grant
Filed:
February 21, 2020
Date of Patent:
October 10, 2023
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: The present disclosure describes a multi-initialization ensemble-based defense strategy against an adversarial attack. In one embodiment, an exemplary method includes training a plurality of conventional neural networks (CNNs) with a training set of images, wherein the images include original images and images modified by an adversarial attack; after training of the plurality of conventional neural networks, providing an input image to the plurality of conventional neural networks, wherein the input image has been modified by an adversarial attack; receiving a probability output for the input image from each of the plurality of conventional neural networks; producing an ensemble probability output for the input image by combining the probability outputs from each of the plurality of conventional neural networks; and labeling the input image as belonging to one of the one or more categories based on the ensemble probability output.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
September 19, 2023
Assignees:
UNIVERSITY OF SOUTH FLORIDA, H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Rahul Paul, Dmitry Goldgof, Lawrence Hall, Matthew Schabath, Robert Gillies
Abstract: Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.
Type:
Grant
Filed:
July 11, 2019
Date of Patent:
August 22, 2023
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Pearlie Burnette, Nicholas J. Lawrence, Harshani Lawrence
Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and sternness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit sternness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
June 27, 2023
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Srikumar Chellappan, Nicholas J. Lawrence, Sujeewa Ranatunga Mahanthe Mudiyanselage
Abstract: Disclosed are compositions and methods comprising the administration of pulsed dendritic cells and an immunoregulator molecule inhibitor for the treatment of cancer.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
May 30, 2023
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., VACCINEX, INC.
Inventors:
Brian Czerniecki, Krithika N. Kodumudi, Elizabeth Evans
Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
May 9, 2023
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors:
Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
Abstract: A method of distinguishing between lung squamous cell carcinoma and head and neck squamous cell carcinoma using a 22-gene biomarker signature is presented.
Type:
Grant
Filed:
August 7, 2019
Date of Patent:
May 9, 2023
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Anthony M. Magliocco, Soner Altiok, Farah K. Khalil, Yin Xiong
Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.
Type:
Grant
Filed:
February 17, 2020
Date of Patent:
April 11, 2023
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
Abstract: A method of distinguishing between urothelial carcinoma and squamous cell carcinoma of head and neck and lung primaries is presented. A 19-gene signature was developed which differentiates between metastatic urothelial carcinoma and squamous cell carcinoma in a metastatic site when the primary site is either known or unknown.
Type:
Grant
Filed:
February 25, 2020
Date of Patent:
April 4, 2023
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Anthony M. Magliocco, Soner Altiok, Jasreman Dhillon, Yin Xiong
Abstract: Disclosed are compositions and methods for treating disease or condition caused or exacerbated by S100A9 activity, such as myelodysplastic syndromes (MDS) using a composition comprising an effective amount of a CD33/S100A9 inhibitor.
Type:
Grant
Filed:
June 25, 2019
Date of Patent:
February 21, 2023
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.