Patents Assigned to Hamari Chemicals, LTD
  • Patent number: 4636471
    Abstract: L-carnitine is produced by bringing apocarnitine into contact with hydrase produced by a strain of Enterobacter in an aqueous medium having a pH of 4-10 at a temperature of 20.degree.-60.degree. C., whereby apocarnitine is converted to L-carnitine.
    Type: Grant
    Filed: April 5, 1984
    Date of Patent: January 13, 1987
    Assignee: Hamari Chemicals Ltd.
    Inventors: Usao Nakamura, Makoto Takao, Etsuko Ueno, Kichitaro Kawaguchi
  • Patent number: 4490292
    Abstract: Novel 1,5-benzothiazepine derivatives having the formula; ##STR1## (wherein R.sub.1, R.sub.2 and R.sub.3 each denotes hydrogen, a halogen, a lower alkyl group, a lower alkoxy group or a hydroxy group; R.sub.4 denotes a lower alkyl group, an allyl group, a lower alkoxyalkyl group, a lower alkyl group substituted with a hydroxy group or a halogen, a lower alkylaminoalkyl group or a morpholino lower alkyl group; X denotes a halogen or hydrogen) are produced from corresponding 1,4-benzothiazine by a ring expansion reaction with trimethylhalosilane, hydrogen peroxide and water. The derivatives have analgesic, antipyretic and antiarrythmic activities.
    Type: Grant
    Filed: October 7, 1983
    Date of Patent: December 25, 1984
    Assignee: Hamari Chemicals, Ltd.
    Inventors: Yoshifumi Maki, Magoichi Sako, Naomichi Mitsumori, Sadayuki Maeda, Masahiro Takaya