Abstract: An arrangement for preparing natural tissue in the form of a heart valve, vessel or the like for implantation in which alternately tanning fluid under pressure is applied to a portion of the tissue so as to cause said tissue to assume substantially its natural configuration, and the pressure is relieved so as to result in a flexing of the tissue, while additional tanning fluid is applied to the remainder of the tissue, said tanning fluid being so applied for a time sufficient to cause the tissue to become fixed.