Patents Assigned to HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
  • Publication number: 20200323850
    Abstract: The present invention relates to a kinase inhibitor, comprising a compound of Formula I or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also relates to a pharmaceutical composition comprising the kinase inhibitor, and to uses and methods for using these compounds and compositions to inhibit the activity of wild-type FLT3, mutant FLT3-ITD, PDGFR? and/or PDGFR? kinase in a cell or a subject, as well as uses and methods of these compounds and compositions to preventing or treating kinase-associated conditions in a subject.
    Type: Application
    Filed: December 26, 2017
    Publication date: October 15, 2020
    Applicant: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Qingsong LIU, Jing LIU, Xiaofei LIANG, Beilei WANG, Kailin YU, Zongru JIANG, Cheng CHEN, Chen HU, Wenchao WANG, Fengming ZOU, Qingwang LIU, Feng LI, Wenliang WANG, Li WANG
  • Patent number: 10669238
    Abstract: The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well application of the Bruton's tyrosine kinase inhibitor for the same.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: June 2, 2020
    Assignee: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Jing Liu, Qingsong Liu, Qianmao Liang, Yongfei Chen, Cheng Chen, Aoli Wang, Hong Wu, Kailin Yu, Wei Wang, Chen Hu, Wenchao Wang, Shuang Qi, Beilei Wang, Li Wang
  • Patent number: 10456873
    Abstract: Welding wire for gas protective welding of reduced activation ferritic/martensitic steel and the manufacturing method, chemical components (weight percentage, wt %): C: 0.10˜0.15, Cr: 8.0˜9.0, W: 1.0˜1.6, V: 0.15˜0.25, Ta: 0.10˜0.17, Mn: 0.50˜0.70, Si: 0˜0.05, N: 0˜0.02, O, Ni, Cu, Al, and Co: 0˜0.01 respectively, P, S, Ag, Mo, and Nb: 0˜0.005 respectively, and balance of Fe. The welding wire has Cr equivalent weight of less than 11, Ni equivalent weight of greater than 3.5. It is manufactured with a wire rod through multi-pass drawing. The rod is subject to annealing heat treatment, tempering treatment performed between the passes of drawing. The annealing process is: the rod is at 940˜1020° C. for 20˜60 minutes, and the n cooled to below 650° C. at rate of less than 45° C./hour, air-cooled to room temperature. The tempering process is: the rod is at 760˜820° C. for 0.5˜2 hours. It reduces forming of ? ferrites in welded joints.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 29, 2019
    Assignee: Hefei Institutes of Physical Science, Chinese Academy of Sciences
    Inventors: Bo Huang, Qunying Huang, Junyu Zhang, Yutao Zhai, Chunjing Li, Shaojun Liu, Yican Wu
  • Patent number: 10266535
    Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: April 23, 2019
    Assignees: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, HEFEI COSOURCE PHARMACEUTICAL CO., LTD.
    Inventors: Jing Liu, Qingsong Liu, Xixiang Li, Aoli Wang, Hong Wu, Cheng Chen, Wenchao Wang, Chen Hu, Zheng Zhao, Jiaxin Wu, Juan Liu, Kailin Yu, Wei Wang, Li Wang, Beilei Wang
  • Publication number: 20190040013
    Abstract: The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well application of the Bruton's tyrosine kinase inhibitor for the same.
    Type: Application
    Filed: December 22, 2016
    Publication date: February 7, 2019
    Applicant: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Jing LIU, Qingsong LIU, Qianmao LIANG, Yongfei CHEN, Cheng CHEN, Aoli WANG, Hong WU, Kailin YU, Wei WANG, Chen HU, Wenchao WANG, Shuang QI, Beilei WANG, Li WANG
  • Publication number: 20180030054
    Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).
    Type: Application
    Filed: August 7, 2015
    Publication date: February 1, 2018
    Applicants: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, HEFEI COSOURCE PHARMACEUTICAL CO., LTD.
    Inventors: Jing LIU, Qingsong LIU, Xixiang LI, Aoli WANG, Hong WU, Cheng CHEN, Wenchao WANG, Chen HU, Zheng ZHAO, Jiaxin WU, Juan LIU, Kailin YU, Wei WANG, Li WANG, Beilei WANG
  • Patent number: 9814709
    Abstract: The present invention provides a Bruton's tyrosine kinase inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method and use of using the Bruton's tyrosine kinase inhibitor to inhibit the tyrosine kinase activity or treat diseases, disorders or symptoms benefiting from the inhibition of the Bruton's tyrosine kinase (Btk) activity.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 14, 2017
    Assignees: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD.
    Inventors: Qingsong Liu, Jing Liu, Yongfei Chen, Hong Wu, Aoli Wang, Beilei Wang, Chen Hu, Wenchao Wang, Cheng Chen
  • Publication number: 20160340770
    Abstract: A type of High Magnetic Field Assisted PLD System consisting of pulsed laser and PLD cylindrical vacuum chamber inclusive of double-layer clip-sheath cylindrical chamber with water cooling located in the bore hole of superconducting magnet is disclosed. A flange plate in one side of the double-layer clip sheath is equipped with substrate heating table or laser heating table and rotating mechanism; the flange plate in another side is equipped with target components and moving/rotating mechanism. Either the substrate heating table or laser heating table is located in the center area of magnetic field of the superconducting magnet. A PLD (pulsed laser deposition) cylindrical vacuum chamber is located in the slide rail. A sealed laser leading-in chamber and a vacuum-sealed video-unit leading-in chamber is installed on the flange plate in one side of double-layer clip sheath cylindrical chamber.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 24, 2016
    Applicant: Hefei Institutes of Physical Science of Chinese Academy of Sciences
    Inventors: Jianming DAI, Kejun ZHANG, Qinzhuang LIU, Zhigao SHENG, Xuebin ZHU, Wenbin WU, Yuping SUN