Abstract: An automatic ultrasonic imaging inspection method and system based on a six-axis manipulator. The method includes: controlling, by a motion control card, a six-axis manipulator to perform scanning and an external axis motor to move; when scanning, feeding back, by a probe, an echo signal; when the probe moves to another scanning line, sending, by a controller, a displacement information of the probe along a stepping direction to an ultrasonic imaging device; when the external axis motor works, feeding back, by an encoder, a displacement information of the probe along a scanning direction to the ultrasonic imaging device; allowing the external axis motor to work when the probe moves along a scanning line; and generating, by the ultrasonic imaging device, a two-dimensional scanning image according to the echo signal, and the displacement information of the probe along the stepping direction and the scanning direction.