Patents Assigned to Hercon Laboratories Corporation
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Patent number: 5985299Abstract: Cosmetic products and methods of performing skin treatments are disclosed. The products and methods are especially suitable for removing keratotic plugs from the pores of skin. The cosmetic products are based on formulations including non-ionic, film-forming, solvent-activatable polymers as major active ingredients. Especially preferred formulations include N-vinyl formamide as in poly(N-vinyl formamide) as a major active ingredient. In some cases, the formulations are coated onto a backing material to form a patch in order to increase the utility and ease of use of the products. The products are used to remove keratotic plugs by applying the product to the skin, allowing the product to dry, and peeling the product from the skin. Also disclosed is a method for producing the preferred articles provided by the invention.Type: GrantFiled: April 20, 1998Date of Patent: November 16, 1999Assignee: Hercon Laboratories CorporationInventors: Douglas E. Buerger, Thomas J. Atkins
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Patent number: 5762952Abstract: A transdermal delivery system is described, including a backing layer having coated thereon an active drug-containing adhesive layer which includes (a) an acrylic-based adhesive which is self-crosslinking at a temperature of from about 20.degree. C. to about 65.degree. C. and (b) an active drug. A method for manufacturing a transdermal delivery system is also described, including (A) mixing an active drug with an acrylic-based adhesive solution which is self-crosslinking at a temperature of from about 20.degree. C. to about 65.degree. C. to form an active drug-adhesive mixture, (B) forming a coating of the active drug-adhesive mixture on a backing layer, and (C) drying the coating to form an active drug-containing adhesive layer. Examples of the active drug include nitroglycerin and estradiol.Type: GrantFiled: April 27, 1993Date of Patent: June 9, 1998Assignee: Hercon Laboratories CorporationInventors: Scott D. Barnhart, Elio P. Mariani
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Patent number: 5468501Abstract: A device useful for administration of pharmacologically-active substances transdermally, orally, or by means of subdermal implant includes an impermeable backing layer, a plasticized polyvinyl chloride layer, and an adhesive layer, wherein the plasticized polyvinyl chloride layer includes from about 20 up to about 70% by weight of a polyvinyl chloride resin, from about 20 up to about 70% by weight of a plasticizer, and from about 0.5 up to about 35% by weight of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, nitroglycerin, and prostaglandin and optionally excipients.Type: GrantFiled: February 8, 1995Date of Patent: November 21, 1995Assignee: Hercon Laboratories CorporationInventors: Agis Kydonieus, Kishore R. Shah, Bret Berner
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Patent number: 5322695Abstract: Described is a moisture-vapor-permeable and oxygen-permeable adhesive dressing for use in supplying a topical medicament to human skin in a controlled release manner, which dressing is unaffected by and impermeable to water in the liquid phase, which dressing when in use on human skin consists essentially of:(i) a polymeric backing material lamina having two surfaces, a first substantially planar surface and a second substantially planar surface;(ii) adhering to said first planar surface of said backing material a medication reservoir lamina having two surfaces, a first substantially planar surface and a second substantially planar surface, consisting essentially of an intimate mixture of:(a) a polyvinyl chloride polymer;(b) a polymeric plasticizer intimately admixed with said polyvinyl chloride and compatible with said polyvinyl chloride; and(c) a topical medicament compatible with said polyvinyl chloride and said plasticizer;said first substantially planar surface of said medication reservoir lamina adherinType: GrantFiled: August 25, 1992Date of Patent: June 21, 1994Assignee: Hercon Laboratories CorporationInventors: Kishore R. Shah, Agis Kydonieus, Dimitrios Apostolopoulos
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Patent number: 5310559Abstract: Described is a device for the controlled release and delivery to mammalian tissue of a pharmacologically active agent comprising:(i) an impermeable backing member;(ii) a control membrane lamina consisting essentially of a first polymeric composition of matter which consists essentially of at least one C.sub.2 -C.sub.4 lower olefin-C.sub.1 -C.sub.8 alkyl acrylate and/or methacrylate copolymer having 2-90% by weight of alkyl acrylate and/or methacrylate monomeric units, taken alone, or taken further together with in intimate admixture, a second polymeric composition consisting essentially of a C.sub.2 -C.sub.4 polyalkylene corresponding to the C.sub.2 -C.sub.Type: GrantFiled: October 21, 1992Date of Patent: May 10, 1994Assignee: Hercon Laboratories CorporationInventors: Kishore Shah, Agis Kydonieus
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Patent number: 5028431Abstract: Described is an article for the controlled release and delivery to animal tissue of a pharmacologically active agent with or without an excipient and/or enhances which may be a causative factor in the occurrence of non-allergic or allergic contact dermatitis comprising an anti-dermatitis substance.Type: GrantFiled: September 13, 1989Date of Patent: July 2, 1991Assignee: Hercon Laboratories CorporationInventors: Thomas J. Franz, Kishore R. Shah, Agis Kydonieus
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Patent number: 4792450Abstract: A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising a polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.Type: GrantFiled: June 18, 1986Date of Patent: December 20, 1988Assignee: Hercon Laboratories CorporationInventors: Agis F. Kydonieus, Bret Berner
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Patent number: 4767808Abstract: Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from about 0.5 up to 35% of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients.Type: GrantFiled: November 19, 1987Date of Patent: August 30, 1988Assignee: Hercon Laboratories CorporationInventors: Agis Kydonieus, Kishore R. Shah, Bret Berner
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Patent number: 4764382Abstract: A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising an emulsion polymerized polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.Type: GrantFiled: April 9, 1986Date of Patent: August 16, 1988Assignee: Hercon Laboratories CorporationInventors: Agis F. Kydonieus, Bret Berner
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Patent number: 4758434Abstract: Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from abotu 0.5 up to 35% of pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients.Type: GrantFiled: April 3, 1986Date of Patent: July 19, 1988Assignee: Hercon Laboratories CorporationInventors: Agis Kydonieus, Kishore R. Shah, Bret Berner
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Patent number: RE34089Abstract: Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition, from about 0.5 up to 35% of pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance .[.whereint he.]. .Iadd.wherein the .Iaddend.Type: GrantFiled: July 19, 1990Date of Patent: October 6, 1992Assignee: Hercon Laboratories CorporationInventors: Agis Kydonieus, Kishore R. Shah, Bret Berner