Abstract: The invention provides coated particles with a taste-masked drug substance. The particles comprise a core with the agglomerated active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.
Type:
Grant
Filed:
June 19, 2015
Date of Patent:
June 11, 2019
Assignee:
HERMES ARZNEIMITTEL GMBH
Inventors:
Klaus Dandl, Detlev Haack, Karin Becker, Andreas Zimmer, Claudia Lang, Sharareh Salar Behzadi
Abstract: The invention provides coated particles with a taste-masked drug substance. The particles comprise a core with the agglomerated active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.
Type:
Application
Filed:
June 19, 2015
Publication date:
June 8, 2017
Applicant:
HERMES ARZNEIMITTEL GMBH
Inventors:
Klaus DANDL, Detlev HAACK, Karin BECKER, Andreas ZIMMER, Claudia LANG, Sharareh SALAR BEHZADI
Abstract: The invention provides coated particles with taste-masked N-acetylcysteine. The particles comprise a core with the active ingredient and a coating comprising a triglyceride and a surfactant. The particles exhibit rapid drug release and a stable release profile. Moreover, the invention provides a hot-melt coating method for manufacturing such particles, and pharmaceutical compositions comprising the particles. The method allows the coating of core particles at moderate temperatures, thereby preventing the degradation of the thermolabile active ingredient.
Type:
Grant
Filed:
April 11, 2014
Date of Patent:
May 2, 2017
Assignee:
HERMES ARZNEIMITTEL GMBH
Inventors:
Karin Becker, Detlev Haack, Sharareh Salar Behzadi, Andreas Zimmer